Gene description for MARVELD2
Gene name MARVEL domain containing 2
Gene symbol MARVELD2
Other names/aliases DFNB49
MARVD2
MRVLDC2
Tric
Species Homo sapiens
 Database cross references - MARVELD2
ExoCarta ExoCarta_153562
Vesiclepedia VP_153562
Entrez Gene 153562
HGNC 26401
MIM 610572
UniProt Q8N4S9  
 MARVELD2 identified in exosomes derived from the following tissue/cell type
Breast cancer cells 19415654    
 Gene ontology annotations for MARVELD2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    sensory perception of sound GO:0007605 IMP
    cell-cell junction organization GO:0045216 IMP
    establishment of endothelial barrier GO:0061028 IMP
    bicellular tight junction assembly GO:0070830 IBA
    bicellular tight junction assembly GO:0070830 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    bicellular tight junction GO:0005923 IBA
    bicellular tight junction GO:0005923 IDA
    basolateral plasma membrane GO:0016323 IDA
    apical plasma membrane GO:0016324 IBA
    apical plasma membrane GO:0016324 IDA
    cell junction GO:0030054 IDA
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 IDA
    paranodal junction GO:0033010 IEA
    Schmidt-Lanterman incisure GO:0043220 IEA
    tricellular tight junction GO:0061689 IDA
    tight junction GO:0070160 IDA
 Experiment description of studies that identified MARVELD2 in exosomes
1
Experiment ID 65
MISEV standards
Biophysical techniques
HSP60|HSP27|GAPDH|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19415654    
Organism Homo sapiens
Experiment description Proteomics of MUC1-containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7.
Authors "Staubach S, Razawi H, Hanisch FG."
Journal name PROTEOMICS
Publication year 2009
Sample Breast cancer cells
Sample name MCF-7
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for MARVELD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDUFAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 RAB35 11021
Proximity Label-MS Homo sapiens
4 LAMTOR1 55004
Proximity Label-MS Homo sapiens
5 OCLN 100506658
Proximity Label-MS Homo sapiens
6 CTBS 1486
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TP53 7157
Affinity Capture-MS Homo sapiens
8 LAMP3  
Proximity Label-MS Homo sapiens
9 GJA1 2697
Proximity Label-MS Homo sapiens
10 STK38 11329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CHMP4C 92421
Affinity Capture-MS Homo sapiens
12 PARD3 56288
Proximity Label-MS Homo sapiens
13 LAMP1 3916
Proximity Label-MS Homo sapiens
14 TJP1 7082
Co-localization Homo sapiens
15 NT5DC3 51559
Affinity Capture-MS Homo sapiens
16 RAB2A 5862
Proximity Label-MS Homo sapiens
17 LAMP2 3920
Proximity Label-MS Homo sapiens
18 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
19 ARF6 382
Proximity Label-MS Homo sapiens
20 GAP43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CXADR 1525
Proximity Label-MS Homo sapiens
22 C11orf52 91894
Proximity Label-MS Homo sapiens
23 BAIAP2L1 55971
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 LYN 4067
Proximity Label-MS Homo sapiens
25 NXF1 10482
Affinity Capture-RNA Homo sapiens
26 ERGIC2 51290
Proximity Label-MS Homo sapiens
27 DNAJC5 80331
Proximity Label-MS Homo sapiens
28 B3GAT1  
Proximity Label-MS Homo sapiens
29 CDH1 999
Proximity Label-MS Homo sapiens
30 DIRAS3  
Proximity Label-MS Homo sapiens
31 RAB7A 7879
Proximity Label-MS Homo sapiens
32 TTL 150465
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 RAB11A 8766
Proximity Label-MS Homo sapiens
34 MOV10 4343
Affinity Capture-RNA Homo sapiens
35 ACAD9 28976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 KRAS 3845
Proximity Label-MS Homo sapiens
37 RAB5C 5878
Proximity Label-MS Homo sapiens
38 RHOB 388
Proximity Label-MS Homo sapiens
39 FATE1  
Two-hybrid Homo sapiens
40 ITCH 83737
Co-localization Homo sapiens
41 CAV1 857
Proximity Label-MS Homo sapiens
42 CTDSPL 10217
Proximity Label-MS Homo sapiens
43 ECSIT 51295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 RAP2A 5911
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MARVELD2 is involved
No pathways found





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