Gene description for ATP6V1C2
Gene name ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
Gene symbol ATP6V1C2
Other names/aliases ATP6C2
VMA5
Species Homo sapiens
 Database cross references - ATP6V1C2
ExoCarta ExoCarta_245973
Entrez Gene 245973
HGNC 18264
UniProt Q8NEY4  
 ATP6V1C2 identified in exosomes derived from the following tissue/cell type
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for ATP6V1C2
Molecular Function
    protein dimerization activity GO:0046983 IDA
    protein binding GO:0005515 IPI
    hydrogen-exporting ATPase activity, phosphorylative mechanism GO:0008553 IEA
Biological Process
    cellular iron ion homeostasis GO:0006879 TAS
    phagosome maturation GO:0090382 TAS
    transferrin transport GO:0033572 TAS
    interaction with host GO:0051701 TAS
    ATP hydrolysis coupled proton transport GO:0015991 IEA
    ion transmembrane transport GO:0034220 TAS
    transmembrane transport GO:0055085 TAS
    insulin receptor signaling pathway GO:0008286 TAS
    positive regulation of Wnt signaling pathway GO:0030177 IMP
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 TAS
    lysosomal membrane GO:0005765 IDA
    proton-transporting V-type ATPase, V1 domain GO:0033180 IEA
 Experiment description of studies that identified ATP6V1C2 in exosomes
1
Experiment ID 13
ISEV standards
✔
IEM
EV Biophysical techniques
✔
Alix|RAB4|RAB5B|RAB11|TSG101
EV Cytosolic markers
✔
CD9|AQP2|AQP1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors Pisitkun T, Shen RF, Knepper MA
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
2
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ATP6V1C2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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