Gene description for ATP6V1C2
Gene name ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
Gene symbol ATP6V1C2
Other names/aliases ATP6C2
VMA5
Species Homo sapiens
 Database cross references - ATP6V1C2
ExoCarta ExoCarta_245973
Vesiclepedia VP_245973
Entrez Gene 245973
HGNC 18264
UniProt Q8NEY4  
 ATP6V1C2 identified in sEVs derived from the following tissue/cell type
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for ATP6V1C2
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    proton-transporting ATPase activity, rotational mechanism GO:0046961 IBA
Biological Process
    regulation of macroautophagy GO:0016241 NAS
    positive regulation of Wnt signaling pathway GO:0030177 IMP
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    vacuolar proton-transporting V-type ATPase, V1 domain GO:0000221 IBA
    lysosomal membrane GO:0005765 HDA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ATP6V1C2 in sEVs
1
Experiment ID 13
MISEV standards
✔
IEM
Biophysical techniques
✔
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
2
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ATP6V1C2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP6V1B2 526
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 STK24 8428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TOMM34 10953
Affinity Capture-MS Homo sapiens
4 C18orf21  
Affinity Capture-MS Homo sapiens
5 CKM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 HPCAL1 3241
Affinity Capture-MS Homo sapiens
7 ATP6V1C1 528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
8 ATP6V1G1 9550
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SYT5 6861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ATP6V1D 51382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 VAMP3 9341
Affinity Capture-MS Homo sapiens
12 MAGEA2  
Affinity Capture-MS Homo sapiens
13 DMXL1 1657
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 WASF1 8936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ZC3HC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ATP6V1G2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ATP6V1F 9296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 POTEF 728378
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 PDCD10 11235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 VRK1 7443
Affinity Capture-MS Homo sapiens
22 FYN 2534
Affinity Capture-MS Homo sapiens
23 KRTAP12-2  
Two-hybrid Homo sapiens
24 MRPS9 64965
Affinity Capture-MS Homo sapiens
25 KLHL24  
Two-hybrid Homo sapiens
26 ATP6V1A 523
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 REL 5966
Two-hybrid Homo sapiens
28 MEOX2  
Two-hybrid Homo sapiens
29 ATP6V1E2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 NEU2  
Affinity Capture-MS Homo sapiens
31 TTC9C 283237
Affinity Capture-MS Homo sapiens
32 ACTL6B  
Affinity Capture-MS Homo sapiens
33 ATP6V1B1 525
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 HECTD1 25831
Affinity Capture-MS Homo sapiens
35 CCR1  
Affinity Capture-MS Homo sapiens
36 METTL15  
Affinity Capture-MS Homo sapiens
37 SPANXN3  
Two-hybrid Homo sapiens
38 ATP6V1E1 529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ECSIT 51295
Affinity Capture-MS Homo sapiens
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