Gene description for ATP6V1C1
Gene name ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
Gene symbol ATP6V1C1
Other names/aliases ATP6C
ATP6D
VATC
Vma5
Species Homo sapiens
 Database cross references - ATP6V1C1
ExoCarta ExoCarta_528
Entrez Gene 528
HGNC 856
MIM 603097
UniProt P21283  
 ATP6V1C1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Urine 19056867    
 Gene ontology annotations for ATP6V1C1
Molecular Function
    hydrogen-exporting ATPase activity, phosphorylative mechanism GO:0008553 IEA
    protein binding GO:0005515 IPI
    proton-transporting ATPase activity, rotational mechanism GO:0046961 TAS
    transporter activity GO:0005215 NAS
Biological Process
    transferrin transport GO:0033572 TAS
    interaction with host GO:0051701 TAS
    ion transmembrane transport GO:0034220 TAS
    transmembrane transport GO:0055085 TAS
    ATP hydrolysis coupled proton transport GO:0015991 IEA
    cellular iron ion homeostasis GO:0006879 TAS
    phagosome maturation GO:0090382 TAS
    insulin receptor signaling pathway GO:0008286 TAS
    proton transport GO:0015992 TAS
Subcellular Localization
    cytoplasmic vesicle GO:0031410 IEA
    lysosomal membrane GO:0005765 IDA
    plasma membrane GO:0005886 ISS
    apical part of cell GO:0045177 IEA
    cytosol GO:0005829 TAS
    proton-transporting two-sector ATPase complex GO:0016469 TAS
    proton-transporting V-type ATPase, V1 domain GO:0033180 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified ATP6V1C1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ATP6V1C1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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