Gene description for TBC1D15
Gene name TBC1 domain family, member 15
Gene symbol TBC1D15
Other names/aliases RAB7-GAP
Species Homo sapiens
 Database cross references - TBC1D15
ExoCarta ExoCarta_64786
Entrez Gene 64786
HGNC 25694
MIM 612662
UniProt Q8TC07  
 TBC1D15 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for TBC1D15
Molecular Function
    GTPase activator activity GO:0005096 ISS
    protein binding GO:0005515 IPI
Biological Process
    regulation of GTPase activity GO:0043087 ISS
    regulation of cilium assembly GO:1902017 IMP
    positive regulation of GTPase activity GO:0043547 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 IDA
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified TBC1D15 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for TBC1D15
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TBC1D15 is involved
No pathways found





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