Gene description for OPTN
Gene name	optineurin
Gene symbol	OPTN
Other names/aliases	ALS12 FIP2 GLC1E HIP7 HYPL NRP TFIIIA-INTP
Species	Homo sapiens
Database cross references - OPTN
ExoCarta	ExoCarta_10133
Entrez Gene	10133
HGNC	17142
MIM	602432
UniProt	Q96CV9
OPTN identified in exosomes derived from the following tissue/cell type
Bladder cancer cells	20224111

Gene ontology annotations for OPTN

Molecular Function     identical protein binding GO:0042802 IPI     protein binding GO:0005515 IPI     K63-linked polyubiquitin binding GO:0070530 IBA     polyubiquitin binding GO:0031593 IDA     Rab GTPase binding GO:0017137 IPI     protein C-terminus binding GO:0008022 IPI Biological Process     regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 IBA     defense response to Gram-negative bacterium GO:0050829 IMP     Golgi ribbon formation GO:0090161 IDA     negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IEA     signal transduction GO:0007165 TAS     Golgi to plasma membrane protein transport GO:0043001 IMP     negative regulation of receptor recycling GO:0001920 IMP     Golgi organization GO:0007030 IMP     G2/M transition of mitotic cell cycle GO:0000086 TAS     cell death GO:0008219 TAS     macroautophagy GO:0016236 IDA     protein targeting to Golgi GO:0000042 IMP     mitotic cell cycle GO:0000278 TAS Subcellular Localization     recycling endosome GO:0055037 IEA     nucleus GO:0005634 IBA     cytoplasmic membrane-bounded vesicle GO:0016023 IBA     Golgi membrane GO:0000139 TAS     cytoplasm GO:0005737 IDA     autophagosome GO:0005776 IEA     Golgi apparatus GO:0005794 IDA     perinuclear region of cytoplasm GO:0048471 IEA     nucleoplasm GO:0005654 TAS     trans-Golgi network GO:0005802 IDA     cytosol GO:0005829 TAS