Gene description for HTT
Gene name huntingtin
Gene symbol HTT
Other names/aliases HD
IT15
Species Homo sapiens
 Database cross references - HTT
ExoCarta ExoCarta_3064
Vesiclepedia VP_3064
Entrez Gene 3064
HGNC 4851
MIM 613004
UniProt P42858  
 HTT identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for HTT
Molecular Function
    p53 binding GO:0002039 IPI
    identical protein binding GO:0042802 IPI
    transcription factor binding GO:0008134 IBA
    protein binding GO:0005515 IPI
    beta-tubulin binding GO:0048487 IDA
    diazepam binding GO:0050809 IEA
    dynactin binding GO:0034452 IPI
    dynein intermediate chain binding GO:0045505 IDA
    ion channel binding GO:0044325 IDA
    profilin binding GO:0005522 IPI
Biological Process
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
    cell aging GO:0007569 IEA
    striatum development GO:0021756 IEA
    lactate biosynthetic process from pyruvate GO:0019244 IEA
    neural plate formation GO:0021990 IEA
    urea cycle GO:0000050 IEA
    retrograde vesicle-mediated transport, Golgi to ER GO:0006890 IMP
    negative regulation of neuron apoptotic process GO:0043524 IEA
    neuron apoptotic process GO:0051402 IEA
    regulation of mitochondrial membrane potential GO:0051881 IEA
    iron ion homeostasis GO:0055072 IEA
    ER to Golgi vesicle-mediated transport GO:0006888 IEA
    paraxial mesoderm formation GO:0048341 IEA
    positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0031587 IDA
    dopamine receptor signaling pathway GO:0007212 IEA
    determination of adult lifespan GO:0008340 IEA
    social behavior GO:0035176 IEA
    endoplasmic reticulum organization GO:0007029 IEA
    establishment of mitotic spindle orientation GO:0000132 IMP
    Golgi organization GO:0007030 IMP
    spermatogenesis GO:0007283 IEA
    visual learning GO:0008542 IEA
    regulation of protein phosphatase type 2A activity GO:0034047 IMP
    insulin secretion GO:0030073 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    response to calcium ion GO:0051592 IEA
    neuron development GO:0048666 IEA
    olfactory lobe development GO:0021988 IEA
    organ development GO:0048513 IBA
    protein import into nucleus GO:0006606 IEA
    vesicle transport along microtubule GO:0047496 IMP
    grooming behavior GO:0007625 IEA
    L-glutamate import GO:0051938 IEA
    regulation of mitochondrial membrane permeability GO:0046902 IEA
    quinolinate biosynthetic process GO:0019805 IEA
    hormone metabolic process GO:0042445 IEA
    endosomal transport GO:0016197 IEA
    regulation of synaptic plasticity GO:0048167 IEA
    axon cargo transport GO:0008088 IEA
    locomotory behavior GO:0007626 IEA
    citrulline metabolic process GO:0000052 IEA
Subcellular Localization
    dendrite GO:0030425 IDA
    late endosome GO:0005770 IDA
    Golgi apparatus GO:0005794 IDA
    protein complex GO:0043234 IDA
    autophagosome GO:0005776 IDA
    cytosol GO:0005829 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    inclusion body GO:0016234 IEA
    cytoplasmic vesicle membrane GO:0030659 IDA
    endoplasmic reticulum GO:0005783 IDA
    mitochondrion GO:0005739 IEA
    axon GO:0030424 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified HTT in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HTT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HAP1  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 RASA1 5921
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 CXorf27  
Two-hybrid Homo sapiens
4 F8A1 8263
Affinity Capture-Western Homo sapiens
5 GRB2 2885
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 HYPB  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
7 TP53 7157
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
8 TCERG1 10915
Reconstituted Complex Homo sapiens
9 Sin3a  
Reconstituted Complex Mus musculus
10 SP1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
11 ZDHHC17 23390
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
12 HYPK 25764
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 IFT57 55081
Invivo Homo sapiens
14 EGFR 1956
Affinity Capture-Western Homo sapiens
15 ZK1127.9  
Two-hybrid 6239
16 HYPE  
Two-hybrid Homo sapiens
17 CTBP1 1487
Invivo Homo sapiens
18 PRPF40A 55660
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
19 HYPC  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
20 OPTN 10133
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 CREBBP  
Co-fractionation Homo sapiens
22 SH3GL3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
23 Crebbp  
Reconstituted Complex Mus musculus
24 NCOR1  
Two-hybrid Homo sapiens
25 GAPDH 2597
Invitro Homo sapiens
26 SH3GLB1 51100
Reconstituted Complex Homo sapiens
27 UBE2K 3093
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 AP2A2 161
Two-hybrid Homo sapiens
29 Ncor1  
Reconstituted Complex Rattus norvegicus
30 TRIP10 9322
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
31 HIP1 3092
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
32 NEUROD1  
Affinity Capture-Western Homo sapiens
33 MAGEA3  
Two-hybrid Homo sapiens
34 MAP3K10  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 PACSIN1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
36 TPH1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which HTT is involved
No pathways found





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