Gene description for UBE2E3
Gene name ubiquitin-conjugating enzyme E2E 3
Gene symbol UBE2E3
Other names/aliases UBCH9
UbcM2
Species Homo sapiens
 Database cross references - UBE2E3
ExoCarta ExoCarta_10477
Vesiclepedia VP_10477
Entrez Gene 10477
HGNC 12479
MIM 604151
UniProt Q969T4  
 UBE2E3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for UBE2E3
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ubiquitin conjugating enzyme activity GO:0061631 IBA
Biological Process
    protein K63-linked ubiquitination GO:0070534 IBA
    protein K63-linked ubiquitination GO:0070534 IDA
    protein K48-linked ubiquitination GO:0070936 IBA
    protein K48-linked ubiquitination GO:0070936 IDA
    protein K11-linked ubiquitination GO:0070979 IBA
    protein K11-linked ubiquitination GO:0070979 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified UBE2E3 in exosomes
1
Experiment ID 234
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
4
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for UBE2E3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Two-hybrid Homo sapiens
2 RNF167 26001
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
3 NKD2 85409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TARDBP 23435
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 TRIM2  
Two-hybrid Homo sapiens
6 RNF25 64320
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 MKRN3  
Two-hybrid Homo sapiens
8 UBA1 7317
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
9 BRCA1 672
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
10 UBC 7316
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
11 CHFR  
Two-hybrid Homo sapiens
12 TRIM55  
Two-hybrid Homo sapiens
13 TRIM62  
Two-hybrid Homo sapiens
14 MID1 4281
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 FBRS 64319
Affinity Capture-MS Homo sapiens
16 NFE2L2 4780
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
17 RNF10  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 DDA1  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
19 DTX3  
Two-hybrid Homo sapiens
20 RNF5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 CADPS2  
Two-hybrid Homo sapiens
22 Traf7  
Reconstituted Complex Mus musculus
23 TBL1XR1 79718
Affinity Capture-Western Homo sapiens
24 RNF8  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
25 TRIM50  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 HERC4 26091
Reconstituted Complex Homo sapiens
27 RCBTB2  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MARCH5  
Reconstituted Complex Homo sapiens
29 CUL4A 8451
Reconstituted Complex Homo sapiens
30 MID2 11043
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
31 CUL1 8454
Reconstituted Complex Homo sapiens
32 ARIH2 10425
Two-hybrid Homo sapiens
33 WBP2 23558
Two-hybrid Homo sapiens
34 USP7 7874
Affinity Capture-MS Homo sapiens
35 RNF11 26994
Two-hybrid Homo sapiens
36 DET1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
37 UBE2E3 10477
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
38 CNOT4 4850
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 RDH12 145226
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 IPO11 51194
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
41 RNF165  
Two-hybrid Homo sapiens
42 RNF4 6047
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
43 RBX1 9978
Reconstituted Complex Homo sapiens
44 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 MAP1B 4131
Cross-Linking-MS (XL-MS) Homo sapiens
46 RNF115  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
47 HTT 3064
Two-hybrid Homo sapiens
48 DAZAP2  
Two-hybrid Homo sapiens
49 BARD1 580
Reconstituted Complex Homo sapiens
50 RNF166  
Two-hybrid Homo sapiens
51 TRIM32 22954
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 ARRDC3 57561
Two-hybrid Homo sapiens
53 FBXO25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 RNF13 11342
Two-hybrid Homo sapiens
55 ITCH 83737
Reconstituted Complex Homo sapiens
56 TRIM63  
Two-hybrid Homo sapiens
57 ATXN1 6310
Two-hybrid Homo sapiens
58 RING1 6015
Two-hybrid Homo sapiens
59 DTL  
Affinity Capture-MS Homo sapiens
60 ASXL2  
Biochemical Activity Homo sapiens
61 RNF181  
Two-hybrid Homo sapiens
62 USP15 9958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 RC3H2  
Reconstituted Complex Homo sapiens
64 RNF14 9604
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
65 RNF130  
Two-hybrid Homo sapiens
66 RNF150  
Two-hybrid Homo sapiens
67 CUL3 8452
Reconstituted Complex Homo sapiens
68 TTC3 7267
Reconstituted Complex Homo sapiens
69 RNF220  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 ETV5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 TRIM27  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
73 C16orf45  
Affinity Capture-MS Homo sapiens
74 TBL1X 6907
Affinity Capture-Western Homo sapiens
75 DDB1 1642
Affinity Capture-Western Homo sapiens
76 RFWD3  
Two-hybrid Homo sapiens
77 RNF2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 RNF114 55905
Two-hybrid Homo sapiens
79 RNF185  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
80 TRIM39  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
81 MDM2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
82 NEDD4L 23327
Reconstituted Complex Homo sapiens
83 STUB1 10273
Reconstituted Complex Homo sapiens
84 DZIP3  
Two-hybrid Homo sapiens
85 RNF43  
Two-hybrid Homo sapiens
86 TRIM38 10475
Two-hybrid Homo sapiens
87 MUL1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
88 SPOP  
Reconstituted Complex Homo sapiens
89 DTX3L 151636
Two-hybrid Homo sapiens
90 SPRY2 10253
Affinity Capture-MS Homo sapiens
91 TRIM45  
Two-hybrid Homo sapiens
92 ZNF746  
Biochemical Activity Homo sapiens
93 RNF31 55072
Reconstituted Complex Homo sapiens
94 PGPEP1 54858
Two-hybrid Homo sapiens
95 RMND5B  
Two-hybrid Homo sapiens
96 SQSTM1 8878
Proximity Label-MS Homo sapiens
97 ZNRF1  
Two-hybrid Homo sapiens
98 FSD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 OTUB1 55611
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 PCGF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 RCBTB1  
Reconstituted Complex Homo sapiens
102 KLHL42  
Reconstituted Complex Homo sapiens
103 WWP2 11060
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
104 TRIM37  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
105 NCL 4691
Cross-Linking-MS (XL-MS) Homo sapiens
106 CCDC121  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 PECR 55825
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 ZNRF4  
Two-hybrid Homo sapiens
109 RNF111 54778
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
110 TOPORS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 ARID3A  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
112 RANGAP1 5905
Biochemical Activity Homo sapiens
113 UFM1 51569
Two-hybrid Homo sapiens
View the network image/svg+xml



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