Gene description for RNF111
Gene name ring finger protein 111
Gene symbol RNF111
Other names/aliases ARK
Species Homo sapiens
 Database cross references - RNF111
ExoCarta ExoCarta_54778
Vesiclepedia VP_54778
Entrez Gene 54778
HGNC 17384
MIM 605840
UniProt Q6ZNA4  
 RNF111 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RNF111
Molecular Function
    protein binding GO:0005515 IPI
    SUMO polymer binding GO:0032184 IBA
    SUMO polymer binding GO:0032184 IDA
    SMAD binding GO:0046332 IBA
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IMP
    ubiquitin protein ligase activity GO:0061630 TAS
Biological Process
    protein polyubiquitination GO:0000209 IEA
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    pattern specification process GO:0007389 IEA
    protein ubiquitination GO:0016567 IMP
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IBA
    positive regulation of protein ubiquitination GO:0031398 IEA
    global genome nucleotide-excision repair GO:0070911 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    PML body GO:0016605 IEA
    protein-containing complex GO:0032991 IEA
 Experiment description of studies that identified RNF111 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RNF111
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MVP 9961
Two-hybrid Homo sapiens
2 PHF7  
Two-hybrid Homo sapiens
3 XPC  
Affinity Capture-Western Homo sapiens
4 UBE2W  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 ADD3 120
Affinity Capture-MS Homo sapiens
6 FAM189B  
Affinity Capture-MS Homo sapiens
7 UBE2N 7334
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
8 NOTCH2NL 388677
Two-hybrid Homo sapiens
9 CSNK2B 1460
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DTX3L 151636
Two-hybrid Homo sapiens
11 SKIL  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
12 NR4A1  
Affinity Capture-Western Homo sapiens
13 SMAD7  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 ALOXE3  
Affinity Capture-MS Homo sapiens
15 HAL 3034
Affinity Capture-MS Homo sapiens
16 TRIM8  
Two-hybrid Homo sapiens
17 ACTN3 89
Two-hybrid Homo sapiens
18 PSME3 10197
Two-hybrid Homo sapiens
19 UBE2V1 7335
Two-hybrid Homo sapiens
20 UBE2M 9040
Two-hybrid Homo sapiens
21 SDCBP2 27111
Two-hybrid Homo sapiens
22 UBE2E3 10477
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
23 TPX2  
Affinity Capture-MS Homo sapiens
24 EDARADD  
Two-hybrid Homo sapiens
25 NBPF19  
Two-hybrid Homo sapiens
26 TSG101 7251
Two-hybrid Homo sapiens
27 MDFI  
Two-hybrid Homo sapiens
28 NRSN1  
Affinity Capture-MS Homo sapiens
29 MARCH7  
Two-hybrid Homo sapiens
30 UBC 7316
Biochemical Activity Homo sapiens
31 UBE2E1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 KRTAP1-1  
Two-hybrid Homo sapiens
33 KRTAP5-9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 RB1CC1 9821
Affinity Capture-Western Homo sapiens
35 UBE2D4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
37 RBM27  
Affinity Capture-MS Homo sapiens
38 CREB1  
Two-hybrid Homo sapiens
39 DCUN1D5 84259
Affinity Capture-MS Homo sapiens
40 CSNK2A1 1457
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
41 C21orf59 56683
Affinity Capture-MS Homo sapiens
42 GNAQ 2776
Affinity Capture-MS Homo sapiens
43 AP2M1 1173
Two-hybrid Homo sapiens
44 UBE2G2  
Two-hybrid Homo sapiens
45 SMAD6  
Affinity Capture-Western Homo sapiens
46 UBXN7 26043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 UBE2D2 7322
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
48 UBE2I 7329
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 KRTAP15-1  
Affinity Capture-MS Homo sapiens
50 SKI 6497
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
51 TSPYL1 7259
Two-hybrid Homo sapiens
52 CGGBP1 8545
Affinity Capture-MS Homo sapiens
53 SPAST 6683
Affinity Capture-MS Homo sapiens
54 UBE2E2  
Two-hybrid Homo sapiens
55 TRIM21 6737
Two-hybrid Homo sapiens
56 CTBP1 1487
Two-hybrid Homo sapiens
57 UBE2K 3093
Two-hybrid Homo sapiens
58 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SMAD3 4088
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 TRAF5  
Two-hybrid Homo sapiens
61 RNF111 54778
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
62 SUMO2 6613
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
63 ESRP2 80004
Affinity Capture-Western Homo sapiens
64 SMAD2 4087
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
65 UBE2L3 7332
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
66 TTC9C 283237
Affinity Capture-MS Homo sapiens
67 AXIN2 8313
Affinity Capture-Western Homo sapiens
68 FBLN5 10516
Affinity Capture-MS Homo sapiens
69 UBE2Q2 92912
Two-hybrid Homo sapiens
70 UBE2D3 7323
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
71 LCE4A  
Two-hybrid Homo sapiens
72 SMURF2 64750
Two-hybrid Homo sapiens
73 ESRP1 54845
Affinity Capture-Western Homo sapiens
74 PML 5371
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
75 SUGP1  
Affinity Capture-MS Homo sapiens
76 ANAPC11  
Two-hybrid Homo sapiens
77 FHL2 2274
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
78 SUMO3 6612
Reconstituted Complex Homo sapiens
79 SETD7 80854
Affinity Capture-Western Homo sapiens
80 LRSAM1 90678
Two-hybrid Homo sapiens
81 VAPB 9217
Two-hybrid Homo sapiens
82 CT45A5  
Affinity Capture-MS Homo sapiens
83 SUMO1 7341
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
84 UBE2D1 7321
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
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