Gene description for AXIN2
Gene name	axin 2
Gene symbol	AXIN2
Other names/aliases	AXIL ODCRCS
Species	Homo sapiens
Database cross references - AXIN2
ExoCarta	ExoCarta_8313
Vesiclepedia	VP_8313
Entrez Gene	8313
HGNC	904
MIM	604025
UniProt	Q9Y2T1
AXIN2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for AXIN2

Molecular Function     GTPase activator activity GO:0005096 IBA     I-SMAD binding GO:0070411 IEA     armadillo repeat domain binding GO:0070016 IBA     beta-catenin binding GO:0008013 NAS     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IBA     ubiquitin protein ligase binding GO:0031625 IPI     enzyme binding GO:0019899 IPI Biological Process     regulation of transcription, DNA-templated GO:0006355 IBA     negative regulation of cell proliferation GO:0008285 IMP     regulation of mismatch repair GO:0032423 IMP     positive regulation of epithelial to mesenchymal transition GO:0010718 IMP     negative regulation of canonical Wnt signaling pathway GO:0090090 IMP     positive regulation of cell death GO:0010942 IMP     cellular protein localization GO:0034613 IDA     intramembranous ossification GO:0001957 IBA     positive regulation of protein phosphorylation GO:0001934 IMP     cell death GO:0008219 IBA     regulation of centromeric sister chromatid cohesion GO:0070602 IMP     Wnt signaling pathway involved in somitogenesis GO:0090244 IBA     cellular response to organic cyclic compound GO:0071407 IBA     cell proliferation GO:0008283 IEA     negative regulation of osteoblast differentiation GO:0045668 IBA     cell differentiation GO:0030154 IBA     dorsal/ventral axis specification GO:0009950 IBA     odontogenesis GO:0042476 IMP     negative regulation of catenin import into nucleus GO:0035414 IMP     chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003413 IEA     termination of G-protein coupled receptor signaling pathway GO:0038032 IEA     mRNA stabilization GO:0048255 IMP     secondary heart field specification GO:0003139 IEA     maintenance of DNA repeat elements GO:0043570 IMP     regulation of chondrocyte development GO:0061181 IEA     positive regulation of canonical Wnt signaling pathway GO:0090263 TAS     bone mineralization GO:0030282 IEA     positive regulation of GTPase activity GO:0043547 IBA Subcellular Localization     cytosol GO:0005829 TAS     postsynaptic density GO:0014069 IBA     cell cortex GO:0005938 IBA     cytoplasmic microtubule GO:0005881 IBA     centrosome GO:0005813 IDA     microtubule cytoskeleton GO:0015630 IDA     plasma membrane GO:0005886 IBA     Golgi apparatus GO:0005794 IDA     cytoplasm GO:0005737 IDA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     beta-catenin destruction complex GO:0030877 NAS     cytoplasmic membrane-bounded vesicle GO:0016023 IBA