ExoCarta: Gene summary

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Gene description for CHIC2
Gene name	cysteine-rich hydrophobic domain 2
Gene symbol	CHIC2
Other names/aliases	BTL
Species	Homo sapiens
Database cross references - CHIC2
ExoCarta	ExoCarta_26511
Vesiclepedia	VP_26511
Entrez Gene	26511
HGNC	1935
MIM	604332
UniProt	Q9UKJ5
CHIC2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942

Gene ontology annotations for CHIC2

Molecular Function
	protein binding	GO:0005515	IPI
Subcellular Localization
	Golgi apparatus	GO:0005794	IEA
	Golgi-associated vesicle	GO:0005798	IBA
	plasma membrane	GO:0005886	IBA
	plasma membrane	GO:0005886	IDA
	intracellular membrane-bounded organelle	GO:0043231	IDA

Experiment description of studies that identified CHIC2 in exosomes

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for CHIC2

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

KRTAP10-7

Two-hybrid

Homo sapiens

KRTAP10-1

Two-hybrid

Homo sapiens

PLEKHF1

79156

Two-hybrid

Homo sapiens

NOTCH2NL

388677

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

C1QTNF2

Two-hybrid

Homo sapiens

UBE2N

7334

Affinity Capture-MS

Homo sapiens

LCE5A

Two-hybrid

Homo sapiens

SDCBP

6386

Two-hybrid

Homo sapiens

CYSRT1

375791

Two-hybrid

Homo sapiens

KRTAP1-3

Two-hybrid

Homo sapiens

PLEKHF2

79666

Two-hybrid

Homo sapiens

AGXT

Two-hybrid

Homo sapiens

LCE1A

Two-hybrid

Homo sapiens

LCE2C

Two-hybrid

Homo sapiens

DHRS9

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

KRTAP2-3

Two-hybrid

Homo sapiens

LCE1F

Two-hybrid

Homo sapiens

SCNM1

Two-hybrid

Homo sapiens

ADAMTSL4

Two-hybrid

Homo sapiens

LCE3D

Two-hybrid

Homo sapiens

SPERT

Two-hybrid

Homo sapiens

NBPF19

Two-hybrid

Homo sapiens

MDFI

Two-hybrid

Homo sapiens

TOP3B

8940

Two-hybrid

Homo sapiens

ZNF330

Two-hybrid

Homo sapiens

ELAVL1

1994

Affinity Capture-RNA

Homo sapiens

KRTAP5-9

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

PNMA1

9240

Two-hybrid

Homo sapiens

KRTAP1-1

Two-hybrid

Homo sapiens

KRTAP10-3

Two-hybrid

Homo sapiens

HOXA1

3198

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

AXIN2

8313

Two-hybrid

Homo sapiens

OTX1

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

KRTAP12-3

Two-hybrid

Homo sapiens

LCE3A

Two-hybrid

Homo sapiens

CEP44

Two-hybrid

Homo sapiens

KRTAP2-4

Two-hybrid

Homo sapiens

LZTS2

84445

Two-hybrid

Homo sapiens

PLEKHG4

Two-hybrid

Homo sapiens

KRTAP4-12

Two-hybrid

Homo sapiens

ITSN2

50618

Two-hybrid

Homo sapiens

TCF4

Two-hybrid

Homo sapiens

KRTAP6-2

Two-hybrid

Homo sapiens

LCE3C

Two-hybrid

Homo sapiens

POU4F2

Two-hybrid

Homo sapiens

PPARA

Two-hybrid

Homo sapiens

KRTAP10-8

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

ZNF837

Two-hybrid

Homo sapiens

MYPOP

Two-hybrid

Homo sapiens

U2AF2

11338

Two-hybrid

Homo sapiens

KANK2

25959

Two-hybrid

Homo sapiens

REL

5966

Two-hybrid

Homo sapiens

CDR2

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

MEOX2

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

KRT40

Two-hybrid

Homo sapiens

LCN2

3934

Two-hybrid

Homo sapiens

KRTAP4-2

Two-hybrid

Homo sapiens

GMCL1

Two-hybrid

Homo sapiens

MTUS2

23281

Two-hybrid

Homo sapiens

MYF5

Two-hybrid

Homo sapiens

LCE1C

Two-hybrid

Homo sapiens

CATSPER1

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

KRTAP10-9

Two-hybrid

Homo sapiens

View the network

Pathways in which CHIC2 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here