Gene description for CDC20
Gene name cell division cycle 20
Gene symbol CDC20
Other names/aliases CDC20A
bA276H19.3
p55CDC
Species Homo sapiens
 Database cross references - CDC20
ExoCarta ExoCarta_991
Vesiclepedia VP_991
Entrez Gene 991
HGNC 1723
MIM 603618
UniProt Q12834  
 CDC20 identified in sEVs derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for CDC20
Molecular Function
    protein binding GO:0005515 IPI
    anaphase-promoting complex binding GO:0010997 IBA
    anaphase-promoting complex binding GO:0010997 IDA
    ubiquitin-like ligase-substrate adaptor activity GO:1990756 IDA
    ubiquitin ligase activator activity GO:1990757 IBA
Biological Process
    mitotic sister chromatid cohesion GO:0007064 IEA
    mitotic spindle assembly checkpoint signaling GO:0007094 NAS
    regulation of mitotic cell cycle GO:0007346 NAS
    nervous system development GO:0007399 IEA
    protein ubiquitination GO:0016567 IEA
    cell differentiation GO:0030154 IEA
    anaphase-promoting complex-dependent catabolic process GO:0031145 IBA
    anaphase-promoting complex-dependent catabolic process GO:0031145 IDA
    anaphase-promoting complex-dependent catabolic process GO:0031145 NAS
    positive regulation of synaptic plasticity GO:0031915 ISS
    regulation of meiotic nuclear division GO:0040020 IEA
    metaphase/anaphase transition of cell cycle GO:0044784 ISS
    positive regulation of mitotic metaphase/anaphase transition GO:0045842 IDA
    cell division GO:0051301 IEA
    regulation of meiotic cell cycle GO:0051445 NAS
    positive regulation of synapse maturation GO:0090129 ISS
    mitotic spindle assembly GO:0090307 IEA
    positive regulation of ubiquitin protein ligase activity GO:1904668 IDA
    positive regulation of anaphase-promoting complex-dependent catabolic process GO:1905786 IBA
    metaphase/anaphase transition of meiosis I GO:1990949 IMP
Subcellular Localization
    kinetochore GO:0000776 ISS
    spindle pole GO:0000922 IEA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    anaphase-promoting complex GO:0005680 IBA
    anaphase-promoting complex GO:0005680 IDA
    anaphase-promoting complex GO:0005680 NAS
    centrosome GO:0005813 IEA
    spindle GO:0005819 TAS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    mitotic checkpoint complex GO:0033597 IPI
 Experiment description of studies that identified CDC20 in sEVs
1
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CDC20
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 CDC26 246184
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TUBB2A 7280
Affinity Capture-MS Homo sapiens
4 GMNN  
Affinity Capture-Western Homo sapiens
5 Anapc13  
Affinity Capture-MS Mus musculus
6 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CUEDC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 TK1 7083
Reconstituted Complex Homo sapiens
9 BUB1  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SAMM50 25813
Proximity Label-MS Homo sapiens
11 KRT85  
Affinity Capture-MS Homo sapiens
12 ANAPC5 51433
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
13 ANAPC15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 PBRM1 55193
Affinity Capture-MS Homo sapiens
15 ID1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 HSPA1L 3305
Affinity Capture-MS Homo sapiens
17 UBE2C 11065
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
18 TRIM33 51592
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 Sirt2 64383
Affinity Capture-Western Mus musculus
20 MAD2L1BP  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
21 UBC 7316
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
22 CHFR  
Affinity Capture-MS Homo sapiens
23 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
24 Cct2 12461
Affinity Capture-MS Mus musculus
25 RPS3 6188
Affinity Capture-MS Homo sapiens
26 HSF2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 HDAC1 3065
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
28 FZR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 RNH1 6050
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 RAVER1 125950
Affinity Capture-MS Homo sapiens
31 CDC16 8881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
32 CCNA1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
33 CASC5  
Affinity Capture-MS Homo sapiens
34 COPS5 10987
Affinity Capture-MS Homo sapiens
35 YARS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SPATC1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
37 MDC1  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
38 MAD2L2 10459
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ANAPC11  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
40 CDC27 996
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 FBXO5  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 ANAPC7 51434
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
43 Haus1  
Affinity Capture-MS Mus musculus
44 EIF2A 83939
Affinity Capture-MS Homo sapiens
45 CUL1 8454
Affinity Capture-Western Homo sapiens
46 BTRC 8945
Affinity Capture-Western Homo sapiens
47 ANAPC16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 FGFR1 2260
Affinity Capture-MS Homo sapiens
49 MAD2L1 4085
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
50 FBXW5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
51 HSPD1 3329
Affinity Capture-MS Homo sapiens
52 Mad2l1  
Affinity Capture-Western Rattus norvegicus
53 USP37  
Affinity Capture-Western Homo sapiens
54 HSPA8 3312
Affinity Capture-MS Homo sapiens
55 CDKN1B 1027
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
56 TRRAP 8295
Affinity Capture-Western Homo sapiens
57 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 TAS2R13  
Affinity Capture-Western Homo sapiens
59 AURKA 6790
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 RELA 5970
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
61 TCP1 6950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 Anapc5 59008
Affinity Capture-MS Mus musculus
63 CDC23 8697
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
64 CUL3 8452
Affinity Capture-Western Homo sapiens
65 CDKN1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
66 PARK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
67 OTUD7B 56957
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
68 TUBA1A 7846
Affinity Capture-MS Homo sapiens
69 STAU1 6780
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 CCT5 22948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 CPVL 54504
Affinity Capture-MS Homo sapiens
72 E2F1 1869
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
73 CCNB1 891
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
74 UBR5 51366
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
75 TUBA1C 84790
Affinity Capture-MS Homo sapiens
76 KDM5B  
Affinity Capture-MS Homo sapiens
77 Gm9174  
Affinity Capture-MS Mus musculus
78 PLK1 5347
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
79 PPP2CA 5515
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
80 KRT31 3881
Affinity Capture-MS Homo sapiens
81 MYBL2 4605
Affinity Capture-Western Homo sapiens
82 KRT33A  
Affinity Capture-MS Homo sapiens
83 PLEKHO2 80301
Affinity Capture-MS Homo sapiens
84 ANAPC10  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 ANAPC4 29945
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
86 FRY  
Affinity Capture-MS Homo sapiens
87 PAXIP1  
Affinity Capture-MS Homo sapiens
88 Bub1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
89 DAXX  
Affinity Capture-Western Homo sapiens
90 CDT1  
Reconstituted Complex Homo sapiens
91 KIF18A  
Biochemical Activity Homo sapiens
92 CCDC59  
Affinity Capture-MS Homo sapiens
93 TRIP13 9319
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
94 UBE2S  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
95 HSPA5 3309
Affinity Capture-MS Homo sapiens
96 TUBB 203068
Affinity Capture-MS Homo sapiens
97 CCNA2 890
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
98 RNF34  
Affinity Capture-Western Homo sapiens
99 KRTAP19-5  
Affinity Capture-MS Homo sapiens
100 Cdc23  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
101 XPO1 7514
Affinity Capture-MS Homo sapiens
102 EGLN3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
103 CDC25A  
Affinity Capture-MS Homo sapiens
104 MAD1L1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
105 CDC25B 994
Affinity Capture-MS Homo sapiens
106 CCT6A 908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 KRT32  
Affinity Capture-MS Homo sapiens
108 HDAC2 3066
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
109 TUBB4B 10383
Affinity Capture-MS Homo sapiens
110 FOXO1  
Affinity Capture-Western Homo sapiens
111 PRDX1 5052
Affinity Capture-MS Homo sapiens
112 KRTAP9-3  
Affinity Capture-MS Homo sapiens
113 SKP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 RASSF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
115 CCT4 10575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 MAB21L2  
Affinity Capture-MS Homo sapiens
117 DCPS 28960
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
118 AXIN2 8313
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
119 CKS1B  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 TP73  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
121 CLSPN  
Affinity Capture-Western Homo sapiens
122 Anapc16  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
123 Cdc16  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
124 AURKB 9212
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
125 TUBA4A 7277
Affinity Capture-MS Homo sapiens
126 CDK2 1017
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 IST1 9798
Affinity Capture-Western Homo sapiens
128 PTTG1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
129 FBXO43  
Affinity Capture-Western Homo sapiens
130 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
131 HECW2  
Affinity Capture-MS Homo sapiens
132 PPP2R5E 5529
Affinity Capture-MS Homo sapiens
133 CCT8 10694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 HSPA1A 3303
Affinity Capture-MS Homo sapiens
135 Anapc1  
Affinity Capture-MS Mus musculus
136 SIRT2 22933
Biochemical Activity Homo sapiens
137 KRTAP9-2  
Affinity Capture-MS Homo sapiens
138 Bub1b 12236
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
139 DDRGK1 65992
Affinity Capture-MS Homo sapiens
140 HAX1  
Proximity Label-MS Homo sapiens
141 PPP2R5A 5525
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
142 Mad2l1 56150
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
143 HSPA9 3313
Affinity Capture-MS Homo sapiens
144 APBA1  
Affinity Capture-MS Homo sapiens
145 PPP2CB 5516
Affinity Capture-MS Homo sapiens
146 HUWE1 10075
Affinity Capture-MS Homo sapiens
147 PCDHAC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 DAB2IP 153090
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
149 YBX1 4904
Affinity Capture-MS Homo sapiens
150 Anapc2  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
151 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
152 CILP 8483
Affinity Capture-MS Homo sapiens
153 SPOP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
154 CDC20 991
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
155 SIRT6  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
156 TUBG1 7283
Affinity Capture-Western Homo sapiens
157 DNAJA2 10294
Affinity Capture-MS Homo sapiens
158 HDAC6 10013
Affinity Capture-Western Homo sapiens
159 MCL1 4170
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
160 TFDP1  
Affinity Capture-Western Homo sapiens
161 BUB1B  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
162 SPINT2 10653
Affinity Capture-MS Homo sapiens
163 RDH14 57665
Affinity Capture-MS Homo sapiens
164 NINL  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
165 PIM1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
166 DSC1 1823
Affinity Capture-MS Homo sapiens
167 CDC6  
Reconstituted Complex Homo sapiens
168 ANAPC1 64682
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
169 USP22 23326
Affinity Capture-Western Homo sapiens
170 CREBBP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
171 CAPNS1 826
Affinity Capture-MS Homo sapiens
172 TTK 7272
Affinity Capture-Western Homo sapiens
173 BUB3 9184
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
174 MKI67  
Biochemical Activity Homo sapiens
175 CDK1 983
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
176 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 Cdc20  
Affinity Capture-MS Mus musculus
178 PCNA 5111
Affinity Capture-MS Homo sapiens
179 ANAPC2 29882
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
180 TBK1 29110
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
181 UBB 7314
Affinity Capture-MS Homo sapiens
182 IDH2 3418
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
183 NEK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
184 MOV10 4343
Affinity Capture-RNA Homo sapiens
185 MXI1 4601
Affinity Capture-Western Homo sapiens
186 HSF1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
187 RPL23 9349
Affinity Capture-MS Homo sapiens
188 SLC25A51  
Proximity Label-MS Homo sapiens
189 SSSCA1 10534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 HNRNPF 3185
Affinity Capture-MS Homo sapiens
191 CDR2  
Biochemical Activity Homo sapiens
192 KRAS 3845
Negative Genetic Homo sapiens
193 CKS2  
Affinity Capture-MS Homo sapiens
194 PHF8  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
195 RPA3 6119
Proximity Label-MS Homo sapiens
196 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
197 CDC5L 988
Affinity Capture-MS Homo sapiens
198 Cdc26  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which CDC20 is involved
PathwayEvidenceSource
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
Adaptive Immune System TAS Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal TAS Reactome
Amplification of signal from the kinetochores TAS Reactome
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome
APC-Cdc20 mediated degradation of Nek2A TAS Reactome
APC/C-mediated degradation of cell cycle proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Cyclin B TAS Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Securin TAS Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 TAS Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint TAS Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase TAS Reactome
Deubiquitination TAS Reactome
EML4 and NUDC in mitotic spindle formation TAS Reactome
Immune System TAS Reactome
Inactivation of APC/C via direct inhibition of the APC/C complex TAS Reactome
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components TAS Reactome
M Phase TAS Reactome
Metabolism of proteins TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Prometaphase TAS Reactome
Mitotic Spindle Checkpoint TAS Reactome
Phosphorylation of Emi1 TAS Reactome
Post-translational protein modification TAS Reactome
Regulation of APC/C activators between G1/S and early anaphase TAS Reactome
Regulation of mitotic cell cycle TAS Reactome
Resolution of Sister Chromatid Cohesion TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate Formins TAS Reactome
SCF-beta-TrCP mediated degradation of Emi1 TAS Reactome
Separation of Sister Chromatids TAS Reactome
Signal Transduction TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Ub-specific processing proteases TAS Reactome





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