Gene description for MXI1
Gene name MAX interactor 1, dimerization protein
Gene symbol MXI1
Other names/aliases MAD2
MXD2
MXI
bHLHc11
Species Homo sapiens
 Database cross references - MXI1
ExoCarta ExoCarta_4601
Entrez Gene 4601
HGNC 7534
MIM 600020
UniProt P50539  
 MXI1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MXI1
Molecular Function
    transcription corepressor activity GO:0003714 TAS
    DNA binding GO:0003677 IEA
    protein dimerization activity GO:0046983 IEA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of cell proliferation GO:0008285 TAS
    transcription, DNA-templated GO:0006351 IEA
    cytoplasmic sequestering of transcription factor GO:0042994 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
Subcellular Localization
    nucleolus GO:0005730 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified MXI1 in exosomes
1
Experiment ID 234
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MXI1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAX  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
2 SMC3 9126
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which MXI1 is involved
No pathways found





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