Gene description for PPP2R5E
Gene name protein phosphatase 2, regulatory subunit B', epsilon isoform
Gene symbol PPP2R5E
Other names/aliases -
Species Homo sapiens
 Database cross references - PPP2R5E
ExoCarta ExoCarta_5529
Entrez Gene 5529
HGNC 9313
MIM 601647
UniProt Q16537  
 PPP2R5E identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for PPP2R5E
Molecular Function
    protein phosphatase type 2A regulator activity GO:0008601 IEA
    protein binding GO:0005515 IPI
Biological Process
    regulation of protein phosphatase type 2A activity GO:0034047 TAS
    signal transduction GO:0007165 IEA
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified PPP2R5E in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2R5E
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
2 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
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