Gene description for NOD2
Gene name	nucleotide-binding oligomerization domain containing 2
Gene symbol	NOD2
Other names/aliases	ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1
Species	Homo sapiens
Database cross references - NOD2
ExoCarta	ExoCarta_64127
Entrez Gene	64127
HGNC	5331
MIM	605956
UniProt	Q9HC29
NOD2 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for NOD2

Molecular Function     CARD domain binding GO:0050700 IPI     peptidoglycan binding GO:0042834 IDA     protein kinase binding GO:0019901 IPI     enzyme binding GO:0019899 IPI     muramyl dipeptide binding GO:0032500 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA Biological Process     positive regulation of interleukin-1 beta production GO:0032731 IMP     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     maintenance of gastrointestinal epithelium GO:0030277 IMP     nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS     activation of MAPK activity GO:0000187 TAS     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     toll-like receptor 4 signaling pathway GO:0034142 TAS     negative regulation of interleukin-2 production GO:0032703 IEA     negative regulation of interleukin-12 production GO:0032695 IEA     detection of muramyl dipeptide GO:0032498 IDA     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     positive regulation of epithelial cell proliferation GO:0050679 ISS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     regulation of neutrophil chemotaxis GO:0090022 IEA     response to lipopolysaccharide GO:0032496 IEA     detection of biotic stimulus GO:0009595 TAS     regulation of inflammatory response GO:0050727 IC     positive regulation of type 2 immune response GO:0002830 IMP     negative regulation of growth of symbiont in host GO:0044130 IEA     negative regulation of T cell mediated immunity GO:0002710 IEA     positive regulation of stress-activated MAPK cascade GO:0032874 IDA     positive regulation of dendritic cell antigen processing and presentation GO:0002606 ISS     innate immune response GO:0045087 TAS     negative regulation of toll-like receptor 2 signaling pathway GO:0034136 IEA     protein oligomerization GO:0051259 TAS     positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria GO:0006965 IEA     cellular response to organic cyclic compound GO:0071407 IEA     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IDA     negative regulation of interferon-gamma production GO:0032689 IEA     nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 ISS     immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 IEA     negative regulation of NF-kappaB transcription factor activity GO:0032088 IEA     positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 ISS     positive regulation of B cell activation GO:0050871 IDA     positive regulation of interleukin-1 beta secretion GO:0050718 IDA     positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     positive regulation of interleukin-6 production GO:0032755 IDA     positive regulation of interleukin-12 production GO:0032735 IEA     defense response to bacterium GO:0042742 IDA     positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 IEA     activation of MAPK activity involved in innate immune response GO:0035419 ISS     nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 IDA     defense response GO:0006952 TAS     cytokine production involved in immune response GO:0002367 IMP     intracellular signal transduction GO:0035556 IDA     positive regulation of tumor necrosis factor production GO:0032760 IMP     stress-activated MAPK cascade GO:0051403 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     positive regulation of phagocytosis GO:0050766 IEA     positive regulation of Notch signaling pathway GO:0045747 ISS     negative regulation of macrophage apoptotic process GO:2000110 ISS     positive regulation of gamma-delta T cell activation GO:0046645 ISS     defense response to Gram-positive bacterium GO:0050830 IEA     positive regulation of prostaglandin-endoperoxide synthase activity GO:0060585 ISS     response to nutrient GO:0007584 IEA     positive regulation of interleukin-10 production GO:0032733 ISS     macrophage inflammatory protein-1 alpha production GO:0071608 IEA     response to muramyl dipeptide GO:0032495 IDA     negative regulation of tumor necrosis factor production GO:0032720 IEA     JNK cascade GO:0007254 TAS     negative regulation of inflammatory response to antigenic stimulus GO:0002862 IEA     positive regulation of cytokine production involved in inflammatory response GO:1900017 IDA     toll-like receptor 2 signaling pathway GO:0034134 TAS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     positive regulation of oxidoreductase activity GO:0051353 ISS     toll-like receptor 9 signaling pathway GO:0034162 TAS     negative regulation of interleukin-18 production GO:0032701 IEA     toll-like receptor signaling pathway GO:0002224 TAS     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     innate immune response in mucosa GO:0002227 IEA     positive regulation of JNK cascade GO:0046330 IDA     positive regulation of dendritic cell cytokine production GO:0002732 IEA     cellular response to muramyl dipeptide GO:0071225 IDA     response to exogenous dsRNA GO:0043330 IEA     cellular response to peptidoglycan GO:0071224 IEA     detection of bacterium GO:0016045 IDA     cytokine secretion involved in immune response GO:0002374 IMP     positive regulation of prostaglandin-E synthase activity GO:2000363 ISS     positive regulation of interleukin-17 production GO:0032740 IMP     toll-like receptor 3 signaling pathway GO:0034138 TAS Subcellular Localization     cell surface GO:0009986 IDA     basolateral plasma membrane GO:0016323 IEA     cytoskeleton GO:0005856 IDA     plasma membrane GO:0005886 IDA     cytosol GO:0005829 TAS     protein complex GO:0043234 IDA     COP9 signalosome GO:0008180 IDA     vesicle GO:0031982 IDA     cytoplasm GO:0005737 TAS