Gene description for NOD2
Gene name	nucleotide-binding oligomerization domain containing 2
Gene symbol	NOD2
Other names/aliases	ACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1
Species	Homo sapiens
Database cross references - NOD2
ExoCarta	ExoCarta_64127
Vesiclepedia	VP_64127
Entrez Gene	64127
HGNC	5331
MIM	605956
UniProt	Q9HC29
NOD2 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for NOD2

Molecular Function     actin binding GO:0003779 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     enzyme binding GO:0019899 IPI     protein kinase binding GO:0019901 IPI     Hsp70 protein binding GO:0030544 IPI     muramyl dipeptide binding GO:0032500 IDA     pattern recognition receptor activity GO:0038187 IDA     peptidoglycan binding GO:0042834 IDA     ubiquitin binding GO:0043130 IDA     ADP binding GO:0043531 ISS     protein-containing complex binding GO:0044877 IPI     CARD domain binding GO:0050700 IPI     Hsp90 protein binding GO:0051879 IDA Biological Process     temperature homeostasis GO:0001659 ISS     pattern recognition receptor signaling pathway GO:0002221 IDA     innate immune response in mucosa GO:0002227 IEA     adaptive immune response GO:0002250 IEA     positive regulation of dendritic cell antigen processing and presentation GO:0002606 ISS     negative regulation of T cell mediated immunity GO:0002710 IEA     positive regulation of cytokine production involved in immune response GO:0002720 IMP     positive regulation of dendritic cell cytokine production GO:0002732 IEA     biosynthetic process of antibacterial peptides active against Gram-positive bacteria GO:0002815 IEA     positive regulation of type 2 immune response GO:0002830 IMP     negative regulation of inflammatory response to antigenic stimulus GO:0002862 IEA     positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 IEA     phagocytosis GO:0006909 IEA     defense response GO:0006952 TAS     positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria GO:0006965 IEA     JNK cascade GO:0007254 IEA     response to nutrient GO:0007584 IEA     detection of biotic stimulus GO:0009595 TAS     negative regulation of macrophage cytokine production GO:0010936 IEA     detection of bacterium GO:0016045 IDA     maintenance of gastrointestinal epithelium GO:0030277 IMP     regulation of appetite GO:0032098 ISS     response to muramyl dipeptide GO:0032495 IBA     response to muramyl dipeptide GO:0032495 IDA     response to muramyl dipeptide GO:0032495 IMP     detection of muramyl dipeptide GO:0032498 IDA     detection of muramyl dipeptide GO:0032498 IDA     negative regulation of type II interferon production GO:0032689 IEA     negative regulation of interleukin-12 production GO:0032695 IEA     negative regulation of interleukin-18 production GO:0032701 IEA     negative regulation of interleukin-2 production GO:0032703 IEA     negative regulation of tumor necrosis factor production GO:0032720 IEA     positive regulation of interleukin-1 beta production GO:0032731 IDA     positive regulation of interleukin-1 beta production GO:0032731 IMP     positive regulation of interleukin-10 production GO:0032733 ISS     positive regulation of interleukin-12 production GO:0032735 IEA     positive regulation of interleukin-17 production GO:0032740 IMP     positive regulation of interleukin-6 production GO:0032755 IDA     positive regulation of interleukin-8 production GO:0032757 IMP     positive regulation of tumor necrosis factor production GO:0032760 IDA     positive regulation of tumor necrosis factor production GO:0032760 IMP     positive regulation of stress-activated MAPK cascade GO:0032874 IDA     toll-like receptor 2 signaling pathway GO:0034134 IEA     negative regulation of toll-like receptor 2 signaling pathway GO:0034136 IEA     response to endoplasmic reticulum stress GO:0034976 IEA     intracellular signal transduction GO:0035556 IBA     intracellular signal transduction GO:0035556 IDA     intestinal stem cell homeostasis GO:0036335 ISS     defense response to bacterium GO:0042742 IBA     defense response to bacterium GO:0042742 IDA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP     response to exogenous dsRNA GO:0043330 IEA     positive regulation of MAPK cascade GO:0043410 ISS     innate immune response GO:0045087 IDA     innate immune response GO:0045087 NAS     positive regulation of Notch signaling pathway GO:0045747 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of JNK cascade GO:0046330 IDA     positive regulation of gamma-delta T cell activation GO:0046645 ISS     host-mediated regulation of intestinal microbiota composition GO:0048874 ISS     positive regulation of epithelial cell proliferation GO:0050679 ISS     regulation of inflammatory response GO:0050727 IC     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     positive regulation of phagocytosis GO:0050766 IEA     positive regulation of B cell activation GO:0050871 IDA     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP     stress-activated MAPK cascade GO:0051403 IEA     establishment of localization in cell GO:0051649 IEA     positive regulation of macrophage cytokine production GO:0060907 IEA     ERK1 and ERK2 cascade GO:0070371 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 IDA     nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 IDA     cellular response to lipopolysaccharide GO:0071222 IMP     cellular response to peptidoglycan GO:0071224 IEA     cellular response to muramyl dipeptide GO:0071225 IDA     cellular response to muramyl dipeptide GO:0071225 IMP     cellular response to organic cyclic compound GO:0071407 IEA     positive regulation of monocyte chemotactic protein-1 production GO:0071639 IEA     regulation of neutrophil chemotaxis GO:0090022 IEA     xenophagy GO:0098792 IEA     antibacterial innate immune response GO:0140367 IDA     positive regulation of cytokine production involved in inflammatory response GO:1900017 IDA     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IMP     positive regulation of mitophagy GO:1901526 ISS     positive regulation of protein K63-linked ubiquitination GO:1902523 IMP     positive regulation of xenophagy GO:1904417 IEA     negative regulation of macrophage apoptotic process GO:2000110 ISS Subcellular Localization     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 TAS     mitochondrion GO:0005739 IEA     Golgi apparatus GO:0005794 IDA     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     cytoskeleton GO:0005856 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IMP     cell surface GO:0009986 IDA     basolateral plasma membrane GO:0016323 IDA     extrinsic component of plasma membrane GO:0019897 IDA     vesicle GO:0031982 IDA     protein-containing complex GO:0032991 IDA     phagocytic vesicle GO:0045335 IDA