Gene description for NOD1
Gene name nucleotide-binding oligomerization domain containing 1
Gene symbol NOD1
Other names/aliases CARD4
CLR7.1
NLRC1
Species Homo sapiens
 Database cross references - NOD1
ExoCarta ExoCarta_10392
Vesiclepedia VP_10392
Entrez Gene 10392
HGNC 16390
MIM 605980
UniProt Q9Y239  
 NOD1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for NOD1
Molecular Function
    protein homodimerization activity GO:0042803 IPI
    identical protein binding GO:0042802 IPI
    CARD domain binding GO:0050700 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 TAS
    peptidoglycan binding GO:0042834 TAS
Biological Process
    positive regulation of dendritic cell antigen processing and presentation GO:0002606 ISS
    nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS
    toll-like receptor 2 signaling pathway GO:0034134 TAS
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA
    toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS
    defense response to bacterium GO:0042742 IDA
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IDA
    toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS
    defense response GO:0006952 TAS
    stress-activated MAPK cascade GO:0051403 TAS
    toll-like receptor 3 signaling pathway GO:0034138 TAS
    MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS
    innate immune response GO:0045087 TAS
    activation of MAPK activity GO:0000187 TAS
    TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS
    positive regulation of tumor necrosis factor production GO:0032760 IEA
    toll-like receptor 5 signaling pathway GO:0034146 TAS
    intracellular signal transduction GO:0035556 IDA
    inflammatory response GO:0006954 TAS
    detection of biotic stimulus GO:0009595 TAS
    positive regulation of interleukin-6 production GO:0032755 IEA
    toll-like receptor 4 signaling pathway GO:0034142 TAS
    protein oligomerization GO:0051259 TAS
    positive regulation of JNK cascade GO:0046330 IEA
    toll-like receptor signaling pathway GO:0002224 TAS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS
    toll-like receptor 10 signaling pathway GO:0034166 TAS
    JNK cascade GO:0007254 TAS
    interleukin-8 biosynthetic process GO:0042228 IDA
    toll-like receptor 9 signaling pathway GO:0034162 TAS
    apoptotic process GO:0006915 TAS
    defense response to Gram-positive bacterium GO:0050830 IEA
    signal transduction GO:0007165 TAS
    detection of bacterium GO:0016045 IDA
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    apical plasma membrane GO:0016324 IEA
    cytoplasm GO:0005737 TAS
    basolateral plasma membrane GO:0016323 IDA
 Experiment description of studies that identified NOD1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 193
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|CD9
EV Enriched markers
✔
PHB
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 194
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 195
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NOD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CARD6  
Affinity Capture-Western Homo sapiens
2 CASP4  
Affinity Capture-Western Homo sapiens
3 CARD12  
Affinity Capture-Western Homo sapiens
4 CASP8 841
Affinity Capture-Western Homo sapiens
5 CASP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
6 CASP9 842
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
7 CFLAR  
Affinity Capture-Western Homo sapiens
8 CASP1  
Affinity Capture-Western Homo sapiens
9 NOD1 10392
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
10 RIPK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
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