Gene description for SREBF1
Gene name sterol regulatory element binding transcription factor 1
Gene symbol SREBF1
Other names/aliases SREBP-1c
Species Homo sapiens
 Database cross references - SREBF1
ExoCarta ExoCarta_6720
Entrez Gene 6720
HGNC 11289
MIM 184756
UniProt P36956  
 SREBF1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SREBF1
Molecular Function
    sterol response element binding GO:0032810 IDA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 ISS
    protein kinase binding GO:0019901 IEA
    protein complex binding GO:0032403 IEA
    protein dimerization activity GO:0046983 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    sequence-specific DNA binding GO:0043565 IEA
    chromatin binding GO:0003682 IEA
Biological Process
    response to drug GO:0042493 IEA
    circadian rhythm GO:0007623 TAS
    regulation of protein targeting to mitochondrion GO:1903214 IMP
    regulation of fatty acid metabolic process GO:0019217 IEA
    positive regulation of histone deacetylation GO:0031065 IEA
    response to progesterone GO:0032570 IEA
    regulation of protein stability GO:0031647 IMP
    response to glucose GO:0009749 IEA
    aging GO:0007568 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    lipid biosynthetic process GO:0008610 ISS
    response to food GO:0032094 IEA
    transcription, DNA-templated GO:0006351 IEA
    cellular response to fatty acid GO:0071398 IEA
    negative regulation of insulin secretion GO:0046676 IEA
    response to retinoic acid GO:0032526 IEA
    regulation of mitochondrion degradation GO:1903146 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    regulation of heart rate by chemical signal GO:0003062 IEA
    response to glucagon GO:0033762 IEA
    positive regulation of triglyceride biosynthetic process GO:0010867 ISS
    small molecule metabolic process GO:0044281 TAS
    cholesterol metabolic process GO:0008203 IEA
    insulin receptor signaling pathway GO:0008286 IEA
    response to cAMP GO:0051591 IEA
    lipid metabolic process GO:0006629 TAS
    positive regulation of cholesterol biosynthetic process GO:0045542 IEA
    lung development GO:0030324 IEA
    cellular response to starvation GO:0009267 ISS
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 ISS
    endoplasmic reticulum membrane GO:0005789 TAS
    nucleoplasm GO:0005654 TAS
    integral component of membrane GO:0016021 IEA
    Golgi membrane GO:0000139 TAS
    endoplasmic reticulum GO:0005783 IDA
    nucleus GO:0005634 IDA
    nuclear envelope GO:0005635 TAS
    ER to Golgi transport vesicle membrane GO:0012507 IEA
    protein complex GO:0043234 IEA
 Experiment description of studies that identified SREBF1 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SREBF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SP1  
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 NR0B1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
4 UBE2I 7329
Affinity Capture-Western Homo sapiens
5 TWIST2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
6 ID3  
Invivo Homo sapiens
Invitro Homo sapiens
7 LMNA 4000
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
8 YY1 7528
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SREBF1 is involved
RORA activates gene expression IEA Reactome

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