Gene description for KDELR3
Gene name KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
Gene symbol KDELR3
Other names/aliases ERD2L3
Species Homo sapiens
 Database cross references - KDELR3
ExoCarta ExoCarta_11015
Vesiclepedia VP_11015
Entrez Gene 11015
HGNC 6306
UniProt O43731  
 KDELR3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for KDELR3
Molecular Function
    KDEL sequence binding GO:0005046 IDA
    protein binding GO:0005515 IPI
    ER retention sequence binding GO:0046923 IBA
Biological Process
    protein retention in ER lumen GO:0006621 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IDA
    protein transport GO:0015031 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    Golgi membrane GO:0000139 TAS
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    cis-Golgi network GO:0005801 IBA
    transport vesicle GO:0030133 TAS
    COPI-coated vesicle membrane GO:0030663 IDA
 Experiment description of studies that identified KDELR3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KDELR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC4A2 6522
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 REEP5 7905
Affinity Capture-MS Homo sapiens
3 VIPR2  
Affinity Capture-MS Homo sapiens
4 MEX3A  
Affinity Capture-RNA Homo sapiens
5 GPR45  
Affinity Capture-MS Homo sapiens
6 MBOAT7 79143
Affinity Capture-MS Homo sapiens
7 PCDH20  
Affinity Capture-MS Homo sapiens
8 GPR17 2840
Affinity Capture-MS Homo sapiens
9 OPALIN  
Affinity Capture-MS Homo sapiens
10 DUOXA2  
Affinity Capture-MS Homo sapiens
11 TSPAN2 10100
Affinity Capture-MS Homo sapiens
12 LPAR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 BLK 640
Affinity Capture-MS Homo sapiens
14 DPEP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SLC39A4 55630
Affinity Capture-MS Homo sapiens
16 CRELD1 78987
Affinity Capture-MS Homo sapiens
17 SLC2A1 6513
Affinity Capture-MS Homo sapiens
18 TMEM72  
Affinity Capture-MS Homo sapiens
19 LPCAT3 10162
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 P2RY8  
Affinity Capture-MS Homo sapiens
21 FFAR1  
Affinity Capture-MS Homo sapiens
22 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 KDELR1 10945
Cross-Linking-MS (XL-MS) Homo sapiens
24 POTEF 728378
Affinity Capture-MS Homo sapiens
25 VSIG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SYP  
Affinity Capture-MS Homo sapiens
27 GP5 2814
Affinity Capture-MS Homo sapiens
28 KDELR2 11014
Cross-Linking-MS (XL-MS) Homo sapiens
29 ALG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 AGPAT3 56894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 MCM2 4171
Affinity Capture-MS Homo sapiens
33 CARKD 55739
Affinity Capture-MS Homo sapiens
34 GPR182  
Affinity Capture-MS Homo sapiens
35 LPAR2 9170
Affinity Capture-MS Homo sapiens
36 LCN1 3933
Affinity Capture-MS Homo sapiens
37 VIPR1  
Affinity Capture-MS Homo sapiens
38 TMEM63A 9725
Affinity Capture-MS Homo sapiens
39 TMEM56  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 INTS12  
Affinity Capture-MS Homo sapiens
41 SLC1A1 6505
Affinity Capture-MS Homo sapiens
42 SLC22A4 6583
Affinity Capture-MS Homo sapiens
43 SREBF1 6720
Negative Genetic Homo sapiens
44 ATP2A3 489
Affinity Capture-MS Homo sapiens
45 FPR2  
Affinity Capture-MS Homo sapiens
46 SLC22A9  
Affinity Capture-MS Homo sapiens
47 S1PR4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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