Gene description for LPCAT3
Gene name lysophosphatidylcholine acyltransferase 3
Gene symbol LPCAT3
Other names/aliases C3F
LPCAT
LPLAT 5
LPSAT
MBOAT5
OACT5
nessy
Species Homo sapiens
 Database cross references - LPCAT3
ExoCarta ExoCarta_10162
Entrez Gene 10162
HGNC 30244
MIM 611950
UniProt Q6P1A2  
 LPCAT3 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for LPCAT3
Molecular Function
    1-acylglycerophosphocholine O-acyltransferase activity GO:0047184 IMP
Biological Process
    small molecule metabolic process GO:0044281 TAS
    phospholipid metabolic process GO:0006644 TAS
    phosphatidylserine acyl-chain remodeling GO:0036150 TAS
    regulation of plasma lipoprotein particle levels GO:0097006 IEA
    glycerophospholipid biosynthetic process GO:0046474 TAS
    phosphatidylethanolamine acyl-chain remodeling GO:0036152 TAS
    phosphatidylcholine acyl-chain remodeling GO:0036151 TAS
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified LPCAT3 in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LPCAT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LPCAT3 is involved
PathwayEvidenceSource
Acyl chain remodelling of PC TAS Reactome
Acyl chain remodelling of PE TAS Reactome
Acyl chain remodelling of PS TAS Reactome





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