Gene description for SLC5A8
Gene name solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Gene symbol SLC5A8
Other names/aliases AIT
SMCT
SMCT1
Species Homo sapiens
 Database cross references - SLC5A8
ExoCarta ExoCarta_160728
Vesiclepedia VP_160728
Entrez Gene 160728
HGNC 19119
MIM 608044
UniProt Q8N695  
 SLC5A8 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC5A8
Molecular Function
    organic acid:sodium symporter activity GO:0005343 IBA
    protein binding GO:0005515 IPI
    monocarboxylic acid transmembrane transporter activity GO:0008028 TAS
    lactate transmembrane transporter activity GO:0015129 IEA
    propionate transmembrane transporter activity GO:0015552 IEA
    monocarboxylate:sodium symporter activity GO:0140161 IDA
    iodide channel activity GO:0160081 TAS
Biological Process
    monoatomic ion transport GO:0006811 TAS
    sodium ion transport GO:0006814 IBA
    chloride transport GO:0006821 IDA
    acetate transport GO:0006846 IDA
    pyruvate transport GO:0006848 IDA
    apoptotic process GO:0006915 IEA
    iodide transport GO:0015705 IDA
    nitrate transmembrane transport GO:0015706 IDA
    lactate transport GO:0015727 IDA
    propanoate transmembrane transport GO:0015730 IBA
    propanoate transmembrane transport GO:0015730 IDA
    NAD biosynthesis via nicotinamide riboside salvage pathway GO:0034356 TAS
    lactate transmembrane transport GO:0035873 IEA
    nicotinate transport GO:2001142 IDA
Subcellular Localization
    GINS complex GO:0000811 IEA
    plasma membrane GO:0005886 TAS
    apical plasma membrane GO:0016324 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC5A8 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC5A8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MBOAT7 79143
Affinity Capture-MS Homo sapiens
2 COX1 4512
Affinity Capture-MS Homo sapiens
3 KIAA1715 80856
Affinity Capture-MS Homo sapiens
4 PXMP2  
Affinity Capture-MS Homo sapiens
5 TVP23C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ZNF703  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 DAD1 1603
Affinity Capture-MS Homo sapiens
8 SMAP2 64744
Affinity Capture-MS Homo sapiens
9 LPCAT3 10162
Affinity Capture-MS Homo sapiens
10 SLC25A23  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 GK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TSPO 706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CHPT1  
Affinity Capture-MS Homo sapiens
14 CORO2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 MCU 90550
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 GPR89A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TMEM11 8834
Affinity Capture-MS Homo sapiens
18 RAB3B 5865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MTX3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 LMNA 4000
Affinity Capture-MS Homo sapiens
21 CAV1 857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ELOVL4  
Affinity Capture-MS Homo sapiens
23 SLC25A46 91137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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