Gene description for TSPO
Gene name translocator protein (18kDa)
Gene symbol TSPO
Other names/aliases BPBS
BZRP
DBI
IBP
MBR
PBR
PBS
PKBS
PTBR
mDRC
pk18
Species Homo sapiens
 Database cross references - TSPO
ExoCarta ExoCarta_706
Entrez Gene 706
HGNC 1158
MIM 109610
UniProt P30536  
 TSPO identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for TSPO
Molecular Function
    protein binding GO:0005515 IPI
    androgen binding GO:0005497 IEA
    cholesterol binding GO:0015485 TAS
    benzodiazepine receptor activity GO:0008503 IEA
Biological Process
    positive regulation of mitochondrial depolarization GO:0051901 IEA
    response to manganese ion GO:0010042 IEA
    steroid metabolic process GO:0008202 TAS
    cell proliferation GO:0008283 TAS
    contact inhibition GO:0060242 IEA
    chloride transport GO:0006821 IEA
    protein targeting to mitochondrion GO:0006626 TAS
    steroid biosynthetic process GO:0006694 IEA
    negative regulation of glial cell proliferation GO:0060253 IEA
    cellular hypotonic response GO:0071476 IEA
    negative regulation of nitric oxide biosynthetic process GO:0045019 IEA
    response to testosterone GO:0033574 IEA
    response to progesterone GO:0032570 IEA
    negative regulation of tumor necrosis factor production GO:0032720 IEA
    anion transport GO:0006820 TAS
    response to vitamin B1 GO:0010266 IEA
    cellular response to lipopolysaccharide GO:0071222 IEA
    apoptotic process GO:0006915 TAS
    aging GO:0007568 IEA
    regulation of cholesterol transport GO:0032374 TAS
    positive regulation of apoptotic process GO:0043065 IEA
    positive regulation of necrotic cell death GO:0010940 IEA
    synaptic transmission GO:0007268 IEA
    adrenal gland development GO:0030325 IEA
    peripheral nervous system axon regeneration GO:0014012 IEA
    heme biosynthetic process GO:0006783 TAS
    lipid transport GO:0006869 IEA
    glial cell migration GO:0008347 IEA
    positive regulation of glial cell proliferation GO:0060252 IEA
    cellular response to zinc ion GO:0071294 IEA
    regulation of steroid biosynthetic process GO:0050810 IEA
    behavioral response to pain GO:0048266 IEA
    response to drug GO:0042493 IEA
    positive regulation of calcium ion transport GO:0051928 IEA
    positive regulation of reactive oxygen species metabolic process GO:2000379 IEA
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IDA
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IEA
    nuclear membrane GO:0031965 IDA
 Experiment description of studies that identified TSPO in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TSPO
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BZRAP1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which TSPO is involved
No pathways found





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