Gene description for SLC22A16
Gene name solute carrier family 22 (organic cation/carnitine transporter), member 16
Gene symbol SLC22A16
Other names/aliases CT2
FLIPT2
OAT6
OCT6
OKB1
dJ261K5.1
Species Homo sapiens
 Database cross references - SLC22A16
ExoCarta ExoCarta_85413
Entrez Gene 85413
HGNC 20302
MIM 608276
UniProt Q86VW1  
 SLC22A16 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for SLC22A16
Molecular Function
    organic cation transmembrane transporter activity GO:0015101 IDA
    carnitine transmembrane transporter activity GO:0015226 IDA
    amine transmembrane transporter activity GO:0005275 IDA
Biological Process
    acid secretion GO:0046717 IDA
    spermatogenesis GO:0007283 IEA
    carnitine transmembrane transport GO:1902603 IDA
    multicellular organismal development GO:0007275 IEA
    cell differentiation GO:0030154 IEA
    transmembrane transport GO:0055085 TAS
    sperm motility GO:0030317 IMP
    organic cation transport GO:0015695 IDA
    amine transport GO:0015837 IDA
    carnitine transport GO:0015879 IDA
    single fertilization GO:0007338 IMP
Subcellular Localization
    integral component of membrane GO:0016021 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SLC22A16 in exosomes
1
Experiment ID 193
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✔
PHB
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC22A16
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC22A16 is involved
PathwayEvidenceSource
Organic cation transport TAS Reactome





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