Gene description for ORAI1
Gene name ORAI calcium release-activated calcium modulator 1
Gene symbol ORAI1
Other names/aliases CRACM1
IMD9
ORAT1
TAM2
TMEM142A
Species Homo sapiens
 Database cross references - ORAI1
ExoCarta ExoCarta_84876
Entrez Gene 84876
HGNC 25896
MIM 610277
UniProt Q96D31  
 ORAI1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for ORAI1
Molecular Function
    identical protein binding GO:0042802 IPI
    store-operated calcium channel activity GO:0015279 IDA
    calmodulin binding GO:0005516 IEA
    protein binding GO:0005515 IPI
Biological Process
    calcium ion transmembrane transport GO:0070588 IEA
    immune system process GO:0002376 IEA
    blood coagulation GO:0007596 TAS
    regulation of calcium ion transport GO:0051924 IMP
    positive regulation of calcium ion transport GO:0051928 IDA
    store-operated calcium entry GO:0002115 IEA
Subcellular Localization
    membrane GO:0016020 IDA
    integral component of plasma membrane GO:0005887 IDA
    autophagosome GO:0005776 IDA
    protein complex GO:0043234 IEA
 Experiment description of studies that identified ORAI1 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for ORAI1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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