Gene description for ORAI1
Gene name	ORAI calcium release-activated calcium modulator 1
Gene symbol	ORAI1
Other names/aliases	CRACM1 IMD9 ORAT1 TAM2 TMEM142A
Species	Homo sapiens
Database cross references - ORAI1
ExoCarta	ExoCarta_84876
Vesiclepedia	VP_84876
Entrez Gene	84876
HGNC	25896
MIM	610277
UniProt	Q96D31
ORAI1 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells	25844599

Gene ontology annotations for ORAI1

Molecular Function     calcium channel activity GO:0005262 IDA     protein binding GO:0005515 IPI     calmodulin binding GO:0005516 IEA     store-operated calcium channel activity GO:0015279 IBA     store-operated calcium channel activity GO:0015279 IDA     identical protein binding GO:0042802 IPI Biological Process     store-operated calcium entry GO:0002115 IBA     store-operated calcium entry GO:0002115 IDA     adaptive immune response GO:0002250 IEA     phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IEA     positive regulation of insulin secretion GO:0032024 IEA     calcineurin-NFAT signaling cascade GO:0033173 IMP     positive regulation of adenylate cyclase activity GO:0045762 IDA     regulation of calcium ion transport GO:0051924 IMP     positive regulation of calcium ion transport GO:0051928 IDA     mammary gland epithelium development GO:0061180 IEA     calcium ion import GO:0070509 IEA     calcium ion transmembrane transport GO:0070588 IDA     calcium ion transmembrane transport GO:0070588 IEA     ion channel modulating, G protein-coupled receptor signaling pathway GO:0099105 IEA     ligand-gated ion channel signaling pathway GO:1990806 IEA Subcellular Localization     plasma membrane GO:0005886 IDA     membrane GO:0016020 HDA     membrane GO:0016020 IBA     basolateral plasma membrane GO:0016323 IEA     calcium channel complex GO:0034704 ISS     plasma membrane raft GO:0044853 IDA     membrane raft GO:0045121 IDA