Gene description for FNDC3A
Gene name fibronectin type III domain containing 3A
Gene symbol FNDC3A
Other names/aliases FNDC3
HUGO
bA203I16.1
bA203I16.5
Species Homo sapiens
 Database cross references - FNDC3A
ExoCarta ExoCarta_22862
Vesiclepedia VP_22862
Entrez Gene 22862
HGNC 20296
MIM 615794
UniProt Q9Y2H6  
 FNDC3A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for FNDC3A
Molecular Function
    RNA binding GO:0003723 HDA
Biological Process
    spermatid development GO:0007286 IBA
    fertilization GO:0009566 IEA
    Sertoli cell development GO:0060009 IEA
    cell-cell adhesion GO:0098609 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    acrosomal vesicle GO:0001669 IEA
    cytoplasm GO:0005737 IBA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IEA
    vesicle membrane GO:0012506 IEA
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified FNDC3A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for FNDC3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OR2M7  
Affinity Capture-MS Homo sapiens
2 SMC3 9126
Affinity Capture-MS Homo sapiens
3 VAPA 9218
Affinity Capture-MS Homo sapiens
4 METTL7A 25840
Proximity Label-MS Homo sapiens
5 LAMP3  
Proximity Label-MS Homo sapiens
6 GJA1 2697
Proximity Label-MS Homo sapiens
7 HPN  
Affinity Capture-MS Homo sapiens
8 HSD17B11 51170
Proximity Label-MS Homo sapiens
9 LAMP2 3920
Proximity Label-MS Homo sapiens
10 DNAJC25 548645
Proximity Label-MS Homo sapiens
11 PTPN1 5770
Proximity Label-MS Homo sapiens
12 STX4 6810
Proximity Label-MS Homo sapiens
13 APP 351
Reconstituted Complex Homo sapiens
14 CTXN1  
Affinity Capture-MS Homo sapiens
15 FAM46C 54855
Affinity Capture-Western Homo sapiens
16 CENPU  
Affinity Capture-MS Homo sapiens
17 B3GAT1  
Proximity Label-MS Homo sapiens
18 SLC26A4 5172
Affinity Capture-MS Homo sapiens
19 OR6T1  
Affinity Capture-MS Homo sapiens
20 RAB3B 5865
Proximity Label-MS Homo sapiens
21 SSR1 6745
Proximity Label-MS Homo sapiens
22 GJD3  
Proximity Label-MS Homo sapiens
23 C3orf52  
Affinity Capture-MS Homo sapiens
24 STX6 10228
Proximity Label-MS Homo sapiens
25 CCDC47 57003
Affinity Capture-MS Homo sapiens
26 GRPR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 HNRNPD 3184
Affinity Capture-MS Homo sapiens
28 Zbtb7a  
Affinity Capture-MS Mus musculus
29 MARCKS 4082
Proximity Label-MS Homo sapiens
30 FADS3 3995
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 Mad2l1bp  
Affinity Capture-MS Mus musculus
32 LMAN1 3998
Proximity Label-MS Homo sapiens
33 NUP155 9631
Proximity Label-MS Homo sapiens
34 KIAA1715 80856
Proximity Label-MS Homo sapiens
35 PXMP2  
Proximity Label-MS Homo sapiens
36 RAB5A 5868
Proximity Label-MS Homo sapiens
37 LMNB1 4001
Proximity Label-MS Homo sapiens
38 EMD 2010
Proximity Label-MS Homo sapiens
39 PDGFRB 5159
Affinity Capture-MS Homo sapiens
40 CXADR 1525
Proximity Label-MS Homo sapiens
41 SORCS2 57537
Affinity Capture-MS Homo sapiens
42 BAG6 7917
Affinity Capture-MS Homo sapiens
43 RAB4A 5867
Proximity Label-MS Homo sapiens
44 KDSR 2531
Affinity Capture-MS Homo sapiens
45 SYT3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 KCNK16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CD1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
49 IL27RA 9466
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 RAB7A 7879
Proximity Label-MS Homo sapiens
51 DNAJC16  
Proximity Label-MS Homo sapiens
52 DHFRL1  
Proximity Label-MS Homo sapiens
53 BTNL3  
Affinity Capture-MS Homo sapiens
54 Ptpn13  
Affinity Capture-MS Mus musculus
55 ELOVL5 60481
Proximity Label-MS Homo sapiens
56 PCDHGA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 NIPSNAP1 8508
Affinity Capture-MS Homo sapiens
58 SEC61B 10952
Proximity Label-MS Homo sapiens
59 RMDN3 55177
Proximity Label-MS Homo sapiens
60 REEP5 7905
Proximity Label-MS Homo sapiens
61 SEC63 11231
Proximity Label-MS Homo sapiens
62 SLC22A16 85413
Affinity Capture-MS Homo sapiens
63 Cdkn2aip  
Affinity Capture-MS Mus musculus
64 SLC30A2  
Affinity Capture-MS Homo sapiens
65 RPN2 6185
Proximity Label-MS Homo sapiens
66 CD151 977
Affinity Capture-MS Homo sapiens
67 LRRC59 55379
Proximity Label-MS Homo sapiens
68 PANX1 24145
Proximity Label-MS Homo sapiens
69 ZDHHC12  
Affinity Capture-MS Homo sapiens
70 ADCY9 115
Affinity Capture-MS Homo sapiens
71 BCAP31 10134
Proximity Label-MS Homo sapiens
72 HSD3B7 80270
Proximity Label-MS Homo sapiens
73 STIM1 6786
Proximity Label-MS Homo sapiens
74 CHRNA7  
Affinity Capture-MS Homo sapiens
75 NIPAL1  
Affinity Capture-MS Homo sapiens
76 FKBP8 23770
Proximity Label-MS Homo sapiens
77 ABTB2 25841
Affinity Capture-MS Homo sapiens
78 PCDH10 57575
Affinity Capture-MS Homo sapiens
79 ATP2A1 487
Proximity Label-MS Homo sapiens
80 MAGEA4 4103
Affinity Capture-MS Homo sapiens
81 RAB9A 9367
Proximity Label-MS Homo sapiens
82 FAM46A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 RPN1 6184
Proximity Label-MS Homo sapiens
84 TNFRSF1B  
Affinity Capture-MS Homo sapiens
85 CYP2C9  
Proximity Label-MS Homo sapiens
86 GRAMD1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 AVPR2  
Affinity Capture-MS Homo sapiens
88 AP3S1 1176
Affinity Capture-MS Homo sapiens
89 SFT2D1 113402
Affinity Capture-MS Homo sapiens
90 GYPA  
Affinity Capture-MS Homo sapiens
91 Tor1aip1  
Affinity Capture-MS Mus musculus
92 TMEM51 55092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 RBM45  
Affinity Capture-MS Homo sapiens
94 CEP170P1  
Affinity Capture-MS Homo sapiens
95 UMODL1  
Affinity Capture-MS Homo sapiens
96 Dync1li1 235661
Affinity Capture-MS Mus musculus
97 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 Rbm8a  
Affinity Capture-MS Mus musculus
99 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
100 DLK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 OR1M1  
Affinity Capture-MS Homo sapiens
102 NUP35 129401
Proximity Label-MS Homo sapiens
103 ERGIC1 57222
Proximity Label-MS Homo sapiens
104 GORASP1 64689
Proximity Label-MS Homo sapiens
105 ERGIC2 51290
Proximity Label-MS Homo sapiens
106 SEC62 7095
Proximity Label-MS Homo sapiens
107 SORT1 6272
Affinity Capture-MS Homo sapiens
108 RAB11A 8766
Proximity Label-MS Homo sapiens
109 DNAJC1 64215
Proximity Label-MS Homo sapiens
110 CKAP4 10970
Proximity Label-MS Homo sapiens
111 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 CUL4A 8451
Affinity Capture-MS Homo sapiens
114 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FNDC3A is involved
No pathways found





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