Gene description for PDGFRB
Gene name	platelet-derived growth factor receptor, beta polypeptide
Gene symbol	PDGFRB
Other names/aliases	CD140B IBGC4 IMF1 JTK12 PDGFR PDGFR-1 PDGFR1
Species	Homo sapiens
Database cross references - PDGFRB
ExoCarta	ExoCarta_5159
Entrez Gene	5159
HGNC	8804
MIM	173410
UniProt	P09619
PDGFRB identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable
Mesenchymal stem cells	25669974

Gene ontology annotations for PDGFRB

Molecular Function     platelet-derived growth factor beta-receptor activity GO:0005019 IMP     platelet activating factor receptor activity GO:0004992 TAS     protein kinase binding GO:0019901 IPI     platelet-derived growth factor binding GO:0048407 IPI     platelet-derived growth factor receptor binding GO:0005161 IPI     platelet-derived growth factor-activated receptor activity GO:0005017 TAS     protein binding GO:0005515 IPI     phosphatidylinositol 3-kinase binding GO:0043548 IEA     receptor binding GO:0005102 IPI     protein tyrosine kinase activity GO:0004713 IDA     vascular endothelial growth factor binding GO:0038085 IPI     ATP binding GO:0005524 IEA Biological Process     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IMP     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     positive regulation of phospholipase C activity GO:0010863 IDA     metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072262 ISS     positive regulation of calcium ion import GO:0090280 ISS     cell migration GO:0016477 IMP     metanephric S-shaped body morphogenesis GO:0072284 IEA     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 IDA     in utero embryonic development GO:0001701 IEA     response to hydrogen peroxide GO:0042542 IEA     positive regulation of phosphoprotein phosphatase activity GO:0032516 IDA     positive regulation of MAP kinase activity GO:0043406 ISS     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793 ISS     wound healing GO:0042060 IEA     smooth muscle tissue development GO:0048745 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 ISS     response to fluid shear stress GO:0034405 IEA     cellular response to platelet-derived growth factor stimulus GO:0036120 TAS     positive regulation of cell migration GO:0030335 IDA     positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 IDA     positive regulation of collagen biosynthetic process GO:0032967 IEA     negative regulation of apoptotic process GO:0043066 IEA     positive regulation of cell proliferation GO:0008284 IMP     signal transduction GO:0007165 IDA     regulation of peptidyl-tyrosine phosphorylation GO:0050730 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     positive regulation of mitotic nuclear division GO:0045840 ISS     cell chemotaxis GO:0060326 IDA     regulation of actin cytoskeleton organization GO:0032956 ISS     phosphatidylinositol metabolic process GO:0046488 IMP     innate immune response GO:0045087 TAS     response to retinoic acid GO:0032526 IEA     tissue homeostasis GO:0001894 IEA     smooth muscle cell chemotaxis GO:0071670 ISS     inner ear development GO:0048839 IEA     positive regulation of smooth muscle cell migration GO:0014911 ISS     metanephric mesenchymal cell migration GO:0035789 IEA     skeletal system morphogenesis GO:0048705 IEA     response to toxic substance GO:0009636 IEA     metanephric comma-shaped body morphogenesis GO:0072278 IEA     protein autophosphorylation GO:0046777 IDA     retina vasculature development in camera-type eye GO:0061298 ISS     G-protein coupled receptor signaling pathway GO:0007186 TAS     adrenal gland development GO:0030325 IEA     platelet-derived growth factor receptor signaling pathway GO:0048008 IDA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     phosphatidylinositol-mediated signaling GO:0048015 TAS     cell migration involved in vasculogenesis GO:0035441 ISS     response to estradiol GO:0032355 IEA     aorta morphogenesis GO:0035909 ISS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     positive regulation of DNA biosynthetic process GO:2000573 ISS     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISS     peptidyl-tyrosine phosphorylation GO:0018108 IDA     response to hyperoxia GO:0055093 IEA     metanephric mesenchyme development GO:0072075 IEA     cell migration involved in coronary angiogenesis GO:0060981 ISS     positive regulation of reactive oxygen species metabolic process GO:2000379 ISS     metanephric glomerular capillary formation GO:0072277 ISS     positive regulation of chemotaxis GO:0050921 ISS     glycosaminoglycan biosynthetic process GO:0006024 IEA     cardiac myofibril assembly GO:0055003 ISS Subcellular Localization     lysosomal lumen GO:0043202 IEA     intrinsic component of plasma membrane GO:0031226 IDA     nucleus GO:0005634 ISS     integral component of membrane GO:0016021 IEA     apical plasma membrane GO:0016324 ISS     focal adhesion GO:0005925 IDA     cell surface GO:0009986 IEA     cytoplasmic membrane-bounded vesicle GO:0016023 IEA     cytoplasm GO:0005737 ISS     extracellular exosome GO:0070062 IDA     plasma membrane GO:0005886 TAS     membrane GO:0016020 IDA