Gene description for PDGFRB
Gene name platelet-derived growth factor receptor, beta polypeptide
Gene symbol PDGFRB
Other names/aliases CD140B
IBGC4
IMF1
JTK12
PDGFR
PDGFR-1
PDGFR1
Species Homo sapiens
 Database cross references - PDGFRB
ExoCarta ExoCarta_5159
Vesiclepedia VP_5159
Entrez Gene 5159
HGNC 8804
MIM 173410
UniProt P09619  
 PDGFRB identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 25669974    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PDGFRB
Molecular Function
    platelet-derived growth factor beta-receptor activity GO:0005019 IMP
    platelet activating factor receptor activity GO:0004992 TAS
    protein kinase binding GO:0019901 IPI
    platelet-derived growth factor binding GO:0048407 IPI
    platelet-derived growth factor receptor binding GO:0005161 IPI
    platelet-derived growth factor-activated receptor activity GO:0005017 TAS
    protein binding GO:0005515 IPI
    phosphatidylinositol 3-kinase binding GO:0043548 IEA
    receptor binding GO:0005102 IPI
    protein tyrosine kinase activity GO:0004713 IDA
    vascular endothelial growth factor binding GO:0038085 IPI
    ATP binding GO:0005524 IEA
Biological Process
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IMP
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    positive regulation of phospholipase C activity GO:0010863 IDA
    metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072262 ISS
    positive regulation of calcium ion import GO:0090280 ISS
    cell migration GO:0016477 IMP
    metanephric S-shaped body morphogenesis GO:0072284 IEA
    positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 IDA
    in utero embryonic development GO:0001701 IEA
    response to hydrogen peroxide GO:0042542 IEA
    positive regulation of phosphoprotein phosphatase activity GO:0032516 IDA
    positive regulation of MAP kinase activity GO:0043406 ISS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS
    positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793 ISS
    wound healing GO:0042060 IEA
    smooth muscle tissue development GO:0048745 IEA
    positive regulation of smooth muscle cell proliferation GO:0048661 ISS
    response to fluid shear stress GO:0034405 IEA
    cellular response to platelet-derived growth factor stimulus GO:0036120 TAS
    positive regulation of cell migration GO:0030335 IDA
    positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 IDA
    positive regulation of collagen biosynthetic process GO:0032967 IEA
    negative regulation of apoptotic process GO:0043066 IEA
    positive regulation of cell proliferation GO:0008284 IMP
    signal transduction GO:0007165 IDA
    regulation of peptidyl-tyrosine phosphorylation GO:0050730 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    positive regulation of mitotic nuclear division GO:0045840 ISS
    cell chemotaxis GO:0060326 IDA
    regulation of actin cytoskeleton organization GO:0032956 ISS
    phosphatidylinositol metabolic process GO:0046488 IMP
    innate immune response GO:0045087 TAS
    response to retinoic acid GO:0032526 IEA
    tissue homeostasis GO:0001894 IEA
    smooth muscle cell chemotaxis GO:0071670 ISS
    inner ear development GO:0048839 IEA
    positive regulation of smooth muscle cell migration GO:0014911 ISS
    metanephric mesenchymal cell migration GO:0035789 IEA
    skeletal system morphogenesis GO:0048705 IEA
    response to toxic substance GO:0009636 IEA
    metanephric comma-shaped body morphogenesis GO:0072278 IEA
    protein autophosphorylation GO:0046777 IDA
    retina vasculature development in camera-type eye GO:0061298 ISS
    G-protein coupled receptor signaling pathway GO:0007186 TAS
    adrenal gland development GO:0030325 IEA
    platelet-derived growth factor receptor signaling pathway GO:0048008 IDA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    cell migration involved in vasculogenesis GO:0035441 ISS
    response to estradiol GO:0032355 IEA
    aorta morphogenesis GO:0035909 ISS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    positive regulation of DNA biosynthetic process GO:2000573 ISS
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISS
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    response to hyperoxia GO:0055093 IEA
    metanephric mesenchyme development GO:0072075 IEA
    cell migration involved in coronary angiogenesis GO:0060981 ISS
    positive regulation of reactive oxygen species metabolic process GO:2000379 ISS
    metanephric glomerular capillary formation GO:0072277 ISS
    positive regulation of chemotaxis GO:0050921 ISS
    glycosaminoglycan biosynthetic process GO:0006024 IEA
    cardiac myofibril assembly GO:0055003 ISS
Subcellular Localization
    lysosomal lumen GO:0043202 IEA
    intrinsic component of plasma membrane GO:0031226 IDA
    nucleus GO:0005634 ISS
    integral component of membrane GO:0016021 IEA
    apical plasma membrane GO:0016324 ISS
    focal adhesion GO:0005925 IDA
    cell surface GO:0009986 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
 Experiment description of studies that identified PDGFRB in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
10
Experiment ID 261
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD81|LAMP2|CD9
Enriched markers
✘ Negative markers
✔
Y
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25669974    
Organism Homo sapiens
Experiment description Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins,and metabolites
Authors Krishna C. Vallabhaneni1, Patrice Penfornis, Santosh Dhule, Francois Guillonneau, Kristen V. Adams, Yin Yuan Mo, Rui Xu, Yiming Liu, Kounosuke Watabe, Mohan C. Vemuri and Radhika Pochampally
Journal name Oncotarget
Publication year 2014
Sample Mesenchymal stem cells
Sample name hMSCs
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Lipids
Metabolites
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
Sequencing
11
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PDGFRB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RASA1 5921
Invivo Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 SNX1 6642
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 PTPN11 5781
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
4 NCK1 4690
Affinity Capture-MS Homo sapiens
5 PDGFB  
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
6 GRB2 2885
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
7 SHC1 6464
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
8 PDAP1 11333
Affinity Capture-MS Homo sapiens
9 CRK 1398
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
10 EIF2AK2 5610
Invivo Homo sapiens
11 ITGB3 3690
Invivo Homo sapiens
Invitro Homo sapiens
12 PDGFRA 5156
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
13 VAV1 7409
Affinity Capture-Western Homo sapiens
14 EGFR 1956
Invivo Homo sapiens
15 GRB10 2887
Invitro Homo sapiens
16 PTK2 5747
Affinity Capture-MS Homo sapiens
17 PDGFRB 5159
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 COPA 1314
Affinity Capture-Western Homo sapiens
19 NCK2 8440
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
20 COPB1 1315
Affinity Capture-MS Homo sapiens
21 KRTAP4-12  
Two-hybrid Homo sapiens
22 FYN 2534
Affinity Capture-MS Homo sapiens
23 BAG1 573
Affinity Capture-MS Homo sapiens
24 S1PR1 1901
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
25 SLC9A3R1 9368
Invivo Homo sapiens
Invitro Homo sapiens
26 GRB14 2888
Reconstituted Complex Homo sapiens
27 RAF1 5894
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
28 SNX2 6643
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
29 SRC 6714
Affinity Capture-MS Homo sapiens
30 SH3KBP1 30011
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
31 VAV2 7410
Affinity Capture-Western Homo sapiens
32 VAV3 10451
Affinity Capture-Western Homo sapiens
33 PLCG1 5335
Affinity Capture-Western Homo sapiens
34 PIK3R1 5295
Invivo Homo sapiens
35 PIK3R3 8503
Affinity Capture-MS Homo sapiens
36 SNX4 8723
Invitro Homo sapiens
View the network image/svg+xml



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