Gene description for PTK2
Gene name	protein tyrosine kinase 2
Gene symbol	PTK2
Other names/aliases	FADK FAK FAK1 FRNK PPP1R71 p125FAK pp125FAK
Species	Homo sapiens
Database cross references - PTK2
ExoCarta	ExoCarta_5747
Entrez Gene	5747
HGNC	9611
MIM	600758
UniProt	Q05397
PTK2 identified in exosomes derived from the following tissue/cell type
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383

Gene ontology annotations for PTK2

Molecular Function     JUN kinase binding GO:0008432 IDA     protein kinase activity GO:0004672 TAS     actin binding GO:0003779 IDA     signal transducer activity GO:0004871 IEA     SH2 domain binding GO:0042169 IPI     ATP binding GO:0005524 IEA     receptor binding GO:0005102 IBA     protein tyrosine kinase activity GO:0004713 ISS     protein kinase binding GO:0019901 IPI     protein binding GO:0005515 IPI     non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA Biological Process     positive regulation of protein kinase B signaling GO:0051897 IMP     positive regulation of cell migration GO:0030335 IDA     establishment of cell polarity GO:0030010 TAS     regulation of cell proliferation GO:0042127 IMP     programmed cell death GO:0012501 TAS     positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 ISS     cell adhesion GO:0007155 IBA     regulation of protein phosphorylation GO:0001932 IGI     regulation of cell adhesion mediated by integrin GO:0033628 IDA     negative regulation of axonogenesis GO:0050771 IEA     peptidyl-tyrosine phosphorylation GO:0018108 ISS     regulation of cytoskeleton organization GO:0051493 TAS     regulation of endothelial cell migration GO:0010594 TAS     regulation of GTPase activity GO:0043087 TAS     embryo development GO:0009790 TAS     vasculogenesis GO:0001570 IEA     regulation of osteoblast differentiation GO:0045667 IMP     cell migration GO:0016477 IBA     positive regulation of protein phosphorylation GO:0001934 IMP     negative regulation of cell-cell adhesion GO:0022408 IDA     cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS     establishment of nucleus localization GO:0040023 IEA     transforming growth factor beta receptor signaling pathway GO:0007179 IDA     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     innate immune response GO:0045087 TAS     extracellular matrix organization GO:0030198 IEA     angiogenesis GO:0001525 TAS     apoptotic process GO:0006915 TAS     platelet activation GO:0030168 TAS     placenta development GO:0001890 TAS     protein autophosphorylation GO:0046777 IDA     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     cytoskeleton organization GO:0007010 IBA     small GTPase mediated signal transduction GO:0007264 TAS     microtubule cytoskeleton organization GO:0000226 IEA     growth hormone receptor signaling pathway GO:0060396 IDA     netrin-activated signaling pathway GO:0038007 TAS     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IMP     blood coagulation GO:0007596 TAS     cell motility GO:0048870 TAS     positive regulation of cell proliferation GO:0008284 ISS     epidermal growth factor receptor signaling pathway GO:0007173 IBA     negative regulation of anoikis GO:2000811 IMP     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 TAS     regulation of cell shape GO:0008360 IMP     negative regulation of apoptotic process GO:0043066 IMP     signal complex assembly GO:0007172 IEA     axon guidance GO:0007411 TAS     heart morphogenesis GO:0003007 TAS     regulation of focal adhesion assembly GO:0051893 TAS     negative regulation of synapse assembly GO:0051964 IEA     ephrin receptor signaling pathway GO:0048013 TAS     neuron migration GO:0001764 IEA     cell differentiation GO:0030154 IBA     central nervous system neuron axonogenesis GO:0021955 IEA     endothelial cell migration GO:0043542 IEA     negative regulation of organ growth GO:0046621 IEA     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     positive regulation of protein kinase activity GO:0045860 IMP     regulation of epithelial cell migration GO:0010632 IGI     regulation of substrate adhesion-dependent cell spreading GO:1900024 IGI     integrin-mediated signaling pathway GO:0007229 TAS Subcellular Localization     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA     cytosol GO:0005829 TAS     apical plasma membrane GO:0016324 IEA     cytoskeleton GO:0005856 TAS     stress fiber GO:0001725 IDA     focal adhesion GO:0005925 IDA     plasma membrane GO:0005886 IDA     lamellipodium GO:0030027 IEA     nucleus GO:0005634 IDA     cell cortex GO:0005938 IEA     microtubule organizing center GO:0005815 IEA     cytoplasm GO:0005737 IDA