Gene description for NEDD9
Gene name neural precursor cell expressed, developmentally down-regulated 9
Gene symbol NEDD9
Other names/aliases CAS-L
CAS2
CASL
CASS2
HEF1
Species Homo sapiens
 Database cross references - NEDD9
ExoCarta ExoCarta_4739
Vesiclepedia VP_4739
Entrez Gene 4739
HGNC 7733
MIM 602265
UniProt Q14511  
 NEDD9 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for NEDD9
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell adhesion GO:0007155 IEA
    actin filament bundle assembly GO:0051017 NAS
    mitotic nuclear division GO:0007067 IEA
    integrin-mediated signaling pathway GO:0007229 NAS
    cytoskeleton organization GO:0007010 NAS
    cell division GO:0051301 IEA
    signal transduction GO:0007165 TAS
    regulation of growth GO:0040008 IEA
Subcellular Localization
    focal adhesion GO:0005925 IEA
    spindle pole GO:0000922 IEA
    lamellipodium GO:0030027 IEA
    cell cortex GO:0005938 IEA
    nucleus GO:0005634 IEA
    Golgi apparatus GO:0005794 IEA
    spindle GO:0005819 TAS
    cytoplasm GO:0005737 TAS
 Experiment description of studies that identified NEDD9 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101|CD63|CD81
EV Enriched markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for NEDD9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ELSPBP1  
Two-hybrid Homo sapiens
2 NCK1 4690
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 BCAR3 8412
Affinity Capture-Western Homo sapiens
4 PXN  
Invivo Homo sapiens
5 ZYX 7791
Invivo Homo sapiens
Two-hybrid Homo sapiens
Invitro Homo sapiens
6 NEDD9 4739
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
7 SH2D3C 10044
Affinity Capture-Western Homo sapiens
8 BCAR1 9564
Invivo Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 LCK 3932
Affinity Capture-Western Homo sapiens
10 ABL1 25
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
11 PTK2 5747
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 LYN 4067
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 SMAD1 4086
Invivo Homo sapiens
14 PTPN12  
Reconstituted Complex Homo sapiens
15 TRIP6  
Two-hybrid Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
16 CDH1 999
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 FYN 2534
Affinity Capture-Western Homo sapiens
18 CRKL 1399
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 CRK 1398
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
20 SMAD3 4088
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
21 PTK2B 2185
Affinity Capture-Western Homo sapiens
22 SMAD2 4087
Invivo Homo sapiens
23 MICAL1 64780
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
24 RAPGEF1 2889
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
25 ITCH 83737
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
26 ID2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NEDD9 is involved
No pathways found





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