Gene description for RAPGEF1
Gene name	Rap guanine nucleotide exchange factor (GEF) 1
Gene symbol	RAPGEF1
Other names/aliases	C3G GRF2
Species	Homo sapiens
Database cross references - RAPGEF1
ExoCarta	ExoCarta_2889
Entrez Gene	2889
HGNC	4568
MIM	600303
UniProt	Q13905
RAPGEF1 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723
Prostate cancer cells	25844599

Gene ontology annotations for RAPGEF1

Molecular Function     Rap guanyl-nucleotide exchange factor activity GO:0017034 IMP     protein binding GO:0005515 IPI     SH3 domain binding GO:0017124 IEA Biological Process     negative regulation of protein kinase B signaling GO:0051898 IEA     regulation of cell junction assembly GO:1901888 IMP     single organismal cell-cell adhesion GO:0016337 IEA     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS     establishment of endothelial barrier GO:0061028 IMP     platelet-derived growth factor receptor signaling pathway GO:0048008 IEA     activation of MAPKK activity GO:0000186 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     nerve growth factor signaling pathway GO:0038180 IDA     blood vessel development GO:0001568 IEA     negative regulation of neural precursor cell proliferation GO:2000178 IEA     negative regulation of canonical Wnt signaling pathway GO:0090090 IEA     positive regulation of GTPase activity GO:0043547 IMP     negative regulation of Ras protein signal transduction GO:0046580 IEA     signal transduction GO:0007165 NAS     negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA     cellular response to nerve growth factor stimulus GO:1990090 IDA     Rap protein signal transduction GO:0032486 IMP     cellular response to cAMP GO:0071320 IDA     positive regulation of neuron projection development GO:0010976 IMP Subcellular Localization     cytosol GO:0005829 TAS     endosome GO:0005768 TAS     early endosome GO:0005769 IDA