Gene description for RAPGEF1
Gene name	Rap guanine nucleotide exchange factor (GEF) 1
Gene symbol	RAPGEF1
Other names/aliases	C3G GRF2
Species	Homo sapiens
Database cross references - RAPGEF1
ExoCarta	ExoCarta_2889
Vesiclepedia	VP_2889
Entrez Gene	2889
HGNC	4568
MIM	600303
UniProt	Q13905
RAPGEF1 identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723
Prostate cancer cells	25844599

Gene ontology annotations for RAPGEF1

Molecular Function     guanyl-nucleotide exchange factor activity GO:0005085 IBA     guanyl-nucleotide exchange factor activity GO:0005085 IDA     guanyl-nucleotide exchange factor activity GO:0005085 IMP     guanyl-nucleotide exchange factor activity GO:0005085 TAS     protein binding GO:0005515 IPI     SH3 domain binding GO:0017124 IEA Biological Process     signal transduction GO:0007165 NAS     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 TAS     Ras protein signal transduction GO:0007265 IBA     nervous system development GO:0007399 IEA     positive regulation of neuron projection development GO:0010976 IMP     Rap protein signal transduction GO:0032486 IMP     nerve growth factor signaling pathway GO:0038180 IDA     positive regulation of GTPase activity GO:0043547 IDA     positive regulation of GTPase activity GO:0043547 IMP     establishment of endothelial barrier GO:0061028 IMP     cellular response to cAMP GO:0071320 IDA     regulation of cell junction assembly GO:1901888 IMP     cellular response to nerve growth factor stimulus GO:1990090 IDA Subcellular Localization     cytoplasm GO:0005737 IDA     early endosome GO:0005769 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     intracellular membrane-bounded organelle GO:0043231 IDA