Gene description for PTPN13
Gene name protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Gene symbol PTPN13
Other names/aliases FAP-1
PNP1
PTP-BAS
PTP-BL
PTP1E
PTPL1
PTPLE
hPTP1E
Species Homo sapiens
 Database cross references - PTPN13
ExoCarta ExoCarta_5783
Entrez Gene 5783
HGNC 9646
MIM 600267
UniProt Q12923  
 PTPN13 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PTPN13
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IMP
    protein binding GO:0005515 IPI
    phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312 IPI
Biological Process
    regulation of phosphatidylinositol 3-kinase signaling GO:0014066 IDA
    protein dephosphorylation GO:0006470 IDA
    peptidyl-tyrosine dephosphorylation GO:0035335 IMP
Subcellular Localization
    neuron projection GO:0043005 IEA
    cytoplasm GO:0005737 IDA
    lamellipodium GO:0030027 IDA
    cell body GO:0044297 IEA
    plasma membrane GO:0005886 IDA
    nucleus GO:0005634 IDA
    extracellular exosome GO:0070062 IDA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified PTPN13 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PTPN13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FASLG 356
Invitro Homo sapiens
2 CTNNB1 1499
Reconstituted Complex Homo sapiens
3 NFKBIA  
Reconstituted Complex Homo sapiens
4 ARHGAP29  
Invitro Homo sapiens
5 PKN2 5586
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
6 TRIP6  
Invitro Homo sapiens
Two-hybrid Homo sapiens
7 Apc  
Two-hybrid Rattus norvegicus
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
8 EFNB1 1947
Reconstituted Complex Homo sapiens
9 APC  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
10 RAPGEF6 51735
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PTPN13 is involved
No pathways found





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