Gene description for RALGPS2
Gene name Ral GEF with PH domain and SH3 binding motif 2
Gene symbol RALGPS2
Other names/aliases dJ595C2.1
Species Homo sapiens
 Database cross references - RALGPS2
ExoCarta ExoCarta_55103
Vesiclepedia VP_55103
Entrez Gene 55103
HGNC 30279
UniProt Q86X27  
 RALGPS2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RALGPS2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
Biological Process
    small GTPase mediated signal transduction GO:0007264 IEA
    positive regulation of GTPase activity GO:0043547 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified RALGPS2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RALGPS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFN 2810
Affinity Capture-MS Homo sapiens
2 YWHAZ 7534
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RALGPS2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here