Gene description for RALGPS2
Gene name Ral GEF with PH domain and SH3 binding motif 2
Gene symbol RALGPS2
Other names/aliases dJ595C2.1
Species Homo sapiens
 Database cross references - RALGPS2
ExoCarta ExoCarta_55103
Vesiclepedia VP_55103
Entrez Gene 55103
HGNC 30279
UniProt Q86X27  
 RALGPS2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RALGPS2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    protein binding GO:0005515 IPI
Biological Process
    Ras protein signal transduction GO:0007265 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified RALGPS2 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RALGPS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 SFN 2810
Affinity Capture-MS Homo sapiens
4 LRFN1  
Affinity Capture-MS Homo sapiens
5 SH3RF3  
Affinity Capture-MS Homo sapiens
6 HDAC4  
Affinity Capture-MS Homo sapiens
7 GIGYF2 26058
Affinity Capture-MS Homo sapiens
8 DENND4C 55667
Affinity Capture-MS Homo sapiens
9 KSR1  
Affinity Capture-MS Homo sapiens
10 KIAA1804  
Affinity Capture-MS Homo sapiens
11 RTKN 6242
Affinity Capture-MS Homo sapiens
12 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DENND1A 57706
Affinity Capture-MS Homo sapiens
14 PPM1H  
Affinity Capture-MS Homo sapiens
15 YWHAE 7531
Affinity Capture-MS Homo sapiens
16 OSBPL6  
Affinity Capture-MS Homo sapiens
17 INPP5E 56623
Affinity Capture-MS Homo sapiens
18 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 KIF13B 23303
Affinity Capture-MS Homo sapiens
20 SRGAP2 23380
Affinity Capture-MS Homo sapiens
21 CAMSAP2  
Affinity Capture-MS Homo sapiens
22 CBY1  
Affinity Capture-MS Homo sapiens
23 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
24 EIF4E2  
Affinity Capture-MS Homo sapiens
25 NF1 4763
Affinity Capture-MS Homo sapiens
26 CDC25C  
Affinity Capture-MS Homo sapiens
27 NADK 65220
Affinity Capture-MS Homo sapiens
28 MYC  
Affinity Capture-MS Homo sapiens
29 PTPN13 5783
Affinity Capture-MS Homo sapiens
30 ZBTB21  
Affinity Capture-MS Homo sapiens
31 GIGYF1  
Affinity Capture-MS Homo sapiens
32 RASAL2 9462
Affinity Capture-MS Homo sapiens
33 LPIN3 64900
Affinity Capture-MS Homo sapiens
34 CGN  
Affinity Capture-MS Homo sapiens
35 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 MAST3  
Affinity Capture-MS Homo sapiens
38 TANC2  
Affinity Capture-MS Homo sapiens
39 KCTD3  
Affinity Capture-MS Homo sapiens
40 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RALGPS2 is involved
No pathways found





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