Gene description for LPIN3
Gene name lipin 3
Gene symbol LPIN3
Other names/aliases LIPN3L
SMP2
Species Homo sapiens
 Database cross references - LPIN3
ExoCarta ExoCarta_64900
Entrez Gene 64900
HGNC 14451
MIM 605520
UniProt Q9BQK8  
 LPIN3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for LPIN3
Molecular Function
    phosphatidate phosphatase activity GO:0008195 IBA
    transcription coactivator activity GO:0003713 IBA
Biological Process
    phosphatidylcholine biosynthetic process GO:0006656 TAS
    fatty acid catabolic process GO:0009062 IBA
    phosphatidylethanolamine biosynthetic process GO:0006646 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IBA
    dephosphorylation GO:0016311 IEA
    triglyceride biosynthetic process GO:0019432 IBA
    phospholipid metabolic process GO:0006644 TAS
    small molecule metabolic process GO:0044281 TAS
    glycerophospholipid biosynthetic process GO:0046474 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified LPIN3 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LPIN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LPIN3 is involved
PathwayEvidenceSource
Depolymerisation of the Nuclear Lamina TAS Reactome
Synthesis of PC TAS Reactome
Synthesis of PE TAS Reactome
Triglyceride Biosynthesis TAS Reactome





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