Gene description for ZNF638
Gene name zinc finger protein 638
Gene symbol ZNF638
Other names/aliases NP220
ZFML
Zfp638
Species Homo sapiens
 Database cross references - ZNF638
ExoCarta ExoCarta_27332
Vesiclepedia VP_27332
Entrez Gene 27332
HGNC 17894
MIM 614349
UniProt Q14966  
 ZNF638 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ZNF638
Molecular Function
    double-stranded DNA binding GO:0003690 TAS
    RNA binding GO:0003723 HDA
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    RNA splicing GO:0008380 IEA
    regulation of RNA splicing GO:0043484 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 TAS
    nuclear speck GO:0016607 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified ZNF638 in exosomes
1
Experiment ID 254
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZNF638
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Proximity Label-MS Homo sapiens
2 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
4 ZNF668  
Affinity Capture-MS Homo sapiens
5 CPSF6 11052
Affinity Capture-MS Homo sapiens
6 PRM2  
Affinity Capture-MS Homo sapiens
7 HDAC4  
Affinity Capture-MS Homo sapiens
8 H1FNT  
Affinity Capture-MS Homo sapiens
9 PPP1CB 5500
Affinity Capture-MS Homo sapiens
10 LGR4 55366
Affinity Capture-MS Homo sapiens
11 CLEC3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 Fus  
Affinity Capture-MS Mus musculus
13 KSR1  
Affinity Capture-MS Homo sapiens
14 WWP1 11059
Two-hybrid Homo sapiens
15 SRPK2 6733
Affinity Capture-MS Homo sapiens
16 EIF4E 1977
Co-fractionation Homo sapiens
17 RPA2 6118
Affinity Capture-MS Homo sapiens
18 RASAL2 9462
Affinity Capture-MS Homo sapiens
19 DHX8 1659
Proximity Label-MS Homo sapiens
20 RPL10 6134
Affinity Capture-MS Homo sapiens
21 KIF20A 10112
Affinity Capture-MS Homo sapiens
22 CDC25B 994
Affinity Capture-MS Homo sapiens
23 SRGAP2 23380
Affinity Capture-MS Homo sapiens
24 VHL  
Negative Genetic Homo sapiens
25 CAND1 55832
Affinity Capture-MS Homo sapiens
26 CAMSAP2  
Affinity Capture-MS Homo sapiens
27 CBY1  
Affinity Capture-MS Homo sapiens
28 HOOK2  
Two-hybrid Homo sapiens
29 EIF4E2  
Affinity Capture-MS Homo sapiens
30 SOX2  
Affinity Capture-MS Homo sapiens
31 RPS3 6188
Affinity Capture-MS Homo sapiens
32 ANKRD50 57182
Affinity Capture-MS Homo sapiens
33 APEX1 328
Affinity Capture-RNA Homo sapiens
34 RPS9 6203
Affinity Capture-MS Homo sapiens
35 RNH1 6050
Co-fractionation Homo sapiens
36 DDX23 9416
Proximity Label-MS Homo sapiens
37 KRTAP4-12  
Two-hybrid Homo sapiens
38 MLLT4 4301
Affinity Capture-MS Homo sapiens
39 KLF8  
Affinity Capture-MS Homo sapiens
40 ZNF524  
Affinity Capture-MS Homo sapiens
41 MPHOSPH8 54737
Affinity Capture-MS Homo sapiens
42 CHCHD2  
Affinity Capture-MS Homo sapiens
43 RAB3IP  
Affinity Capture-MS Homo sapiens
44 MAGI1  
Affinity Capture-MS Homo sapiens
45 PRC1 9055
Affinity Capture-MS Homo sapiens
46 SCRIB 23513
Affinity Capture-MS Homo sapiens
47 BHLHA15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 NPM1 4869
Affinity Capture-MS Homo sapiens
49 SNRPC 6631
Affinity Capture-MS Homo sapiens
50 CALCOCO2  
Two-hybrid Homo sapiens
51 KLF15  
Affinity Capture-MS Homo sapiens
52 OBSL1 23363
Affinity Capture-MS Homo sapiens
53 TIAM1  
Affinity Capture-MS Homo sapiens
54 PHLDB2 90102
Affinity Capture-MS Homo sapiens
55 DCLK1 9201
Affinity Capture-MS Homo sapiens
56 TESK2  
Affinity Capture-MS Homo sapiens
57 EED  
Affinity Capture-MS Homo sapiens
58 PTPN14 5784
Affinity Capture-MS Homo sapiens
59 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ATG16L1 55054
Affinity Capture-MS Homo sapiens
61 E4F1  
Affinity Capture-MS Homo sapiens
62 SFN 2810
Affinity Capture-MS Homo sapiens
63 LRFN1  
Affinity Capture-MS Homo sapiens
64 MECP2 4204
Affinity Capture-MS Homo sapiens
65 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 MYCN  
Affinity Capture-MS Homo sapiens
67 RBM14 10432
Affinity Capture-MS Homo sapiens
68 KIAA1804  
Affinity Capture-MS Homo sapiens
69 KIF14 9928
Affinity Capture-MS Homo sapiens
70 HSPA8 3312
Co-fractionation Homo sapiens
71 MELK  
Affinity Capture-MS Homo sapiens
72 LIN28A  
Affinity Capture-MS Homo sapiens
73 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 AGAP1  
Affinity Capture-MS Homo sapiens
75 ZNF385C  
Affinity Capture-MS Homo sapiens
76 CLK2 1196
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 KRT19 3880
Two-hybrid Homo sapiens
78 CDK16 5127
Affinity Capture-MS Homo sapiens
79 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
80 PLSCR1 5359
Two-hybrid Homo sapiens
81 ANKRD34A  
Affinity Capture-MS Homo sapiens
82 USP21  
Affinity Capture-MS Homo sapiens
83 SH3BP4 23677
Affinity Capture-MS Homo sapiens
84 RPL4 6124
Affinity Capture-MS Homo sapiens
85 FAM110A  
Affinity Capture-MS Homo sapiens
86 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
87 RBM4B  
Affinity Capture-MS Homo sapiens
88 Taf15  
Affinity Capture-MS Mus musculus
89 NEIL1  
Affinity Capture-MS Homo sapiens
90 SRSF6 6431
Affinity Capture-MS Homo sapiens
91 SNRPB 6628
Affinity Capture-MS Homo sapiens
92 HDAC7  
Affinity Capture-MS Homo sapiens
93 YWHAE 7531
Affinity Capture-MS Homo sapiens
94 RNF43  
Proximity Label-MS Homo sapiens
95 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
96 RAD18  
Affinity Capture-MS Homo sapiens
97 GTF3C2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 LPIN3 64900
Affinity Capture-MS Homo sapiens
99 YWHAQ 10971
Affinity Capture-MS Homo sapiens
100 DDX54 79039
Affinity Capture-MS Homo sapiens
101 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
102 FAM110B  
Affinity Capture-MS Homo sapiens
103 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
104 ZBTB21  
Affinity Capture-MS Homo sapiens
105 SRPK3  
Affinity Capture-MS Homo sapiens
106 KCTD3  
Affinity Capture-MS Homo sapiens
107 SF3A3 10946
Co-fractionation Homo sapiens
108 TNFRSF13B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 NADK 65220
Affinity Capture-MS Homo sapiens
110 LARP1 23367
Affinity Capture-MS Homo sapiens
111 RNASEH1 246243
Affinity Capture-MS Homo sapiens
112 CCDC59  
Affinity Capture-MS Homo sapiens
113 FGFBP1 9982
Affinity Capture-MS Homo sapiens
114 LIMA1 51474
Affinity Capture-MS Homo sapiens
115 FANCD2  
Affinity Capture-MS Homo sapiens
116 TOP1 7150
Affinity Capture-MS Homo sapiens
117 CLK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 JPH4 84502
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 SIRT7  
Affinity Capture-MS Homo sapiens
120 NELFCD 51497
Two-hybrid Homo sapiens
121 SRSF4 6429
Affinity Capture-MS Homo sapiens
122 DDX50 79009
Affinity Capture-MS Homo sapiens
123 INPP5E 56623
Affinity Capture-MS Homo sapiens
124 MAPKAPK2 9261
Affinity Capture-MS Homo sapiens
125 USP36  
Affinity Capture-MS Homo sapiens
126 YWHAZ 7534
Affinity Capture-MS Homo sapiens
127 TNPO3 23534
Affinity Capture-MS Homo sapiens
128 NAV1 89796
Affinity Capture-MS Homo sapiens
129 YY1 7528
Co-fractionation Homo sapiens
130 TFPT  
Affinity Capture-MS Homo sapiens
131 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
132 FUS 2521
Affinity Capture-MS Homo sapiens
133 SORD 6652
Cross-Linking-MS (XL-MS) Homo sapiens
134 GTF3C4 9329
Affinity Capture-MS Homo sapiens
135 ZC3H10  
Affinity Capture-MS Homo sapiens
136 PLEKHA5 54477
Affinity Capture-MS Homo sapiens
137 CDC25C  
Affinity Capture-MS Homo sapiens
138 RPA4  
Proximity Label-MS Homo sapiens
139 KIF1BP 26128
Two-hybrid Homo sapiens
140 HECW2  
Affinity Capture-MS Homo sapiens
141 Hnrnpa3 229279
Affinity Capture-MS Mus musculus
142 GIGYF1  
Affinity Capture-MS Homo sapiens
143 ARRDC3 57561
Affinity Capture-MS Homo sapiens
144 CCDC85B  
Two-hybrid Homo sapiens
145 ATG13 9776
Affinity Capture-MS Homo sapiens
146 WASL 8976
Co-fractionation Homo sapiens
147 GNLY  
Affinity Capture-MS Homo sapiens
148 CGN  
Affinity Capture-MS Homo sapiens
149 MATR3 9782
Affinity Capture-MS Homo sapiens
150 CUL7 9820
Affinity Capture-MS Homo sapiens
151 RNF2  
Affinity Capture-MS Homo sapiens
152 BMI1  
Affinity Capture-MS Homo sapiens
153 FAM53C 51307
Affinity Capture-MS Homo sapiens
154 MRPS17 51373
Affinity Capture-MS Homo sapiens
155 Ppp1cb 19046
Affinity Capture-MS Mus musculus
156 NEUROG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
157 FHL2 2274
Two-hybrid Homo sapiens
FRET Homo sapiens
158 PASK  
Affinity Capture-MS Homo sapiens
159 MALL  
Affinity Capture-MS Homo sapiens
160 TBC1D25  
Affinity Capture-MS Homo sapiens
161 DENND4C 55667
Affinity Capture-MS Homo sapiens
162 RPL13 6137
Affinity Capture-MS Homo sapiens
163 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
164 Esrrb  
Affinity Capture-MS Mus musculus
165 FEZ1  
Affinity Capture-MS Homo sapiens
166 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
167 GIGYF2 26058
Affinity Capture-MS Homo sapiens
168 SYDE1 85360
Affinity Capture-MS Homo sapiens
169 STARD13 90627
Affinity Capture-MS Homo sapiens
170 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
171 RBFA  
Affinity Capture-MS Homo sapiens
172 SRRM1 10250
Affinity Capture-MS Homo sapiens
173 RTKN 6242
Affinity Capture-MS Homo sapiens
174 SSU72 29101
Proximity Label-MS Homo sapiens
175 DENND1A 57706
Affinity Capture-MS Homo sapiens
176 APOBEC3D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 SPP1 6696
Two-hybrid Homo sapiens
178 PPP1CC 5501
Affinity Capture-MS Homo sapiens
179 RPA1 6117
Affinity Capture-MS Homo sapiens
180 MEN1 4221
Affinity Capture-MS Homo sapiens
181 SRSF12  
Affinity Capture-MS Homo sapiens
182 SNRPA 6626
Affinity Capture-MS Homo sapiens
183 RPTOR 57521
Affinity Capture-MS Homo sapiens
184 KIF13B 23303
Affinity Capture-MS Homo sapiens
185 SP7  
Proximity Label-MS Homo sapiens
186 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
187 KRT15 3866
Two-hybrid Homo sapiens
188 EDC3 80153
Affinity Capture-MS Homo sapiens
189 H2AFB3  
Affinity Capture-MS Homo sapiens
190 NUP35 129401
Proximity Label-MS Homo sapiens
191 GAB2 9846
Affinity Capture-MS Homo sapiens
192 DHX40  
Proximity Label-MS Homo sapiens
193 PPM1H  
Affinity Capture-MS Homo sapiens
194 NF1 4763
Affinity Capture-MS Homo sapiens
195 Srsf1 110809
Affinity Capture-MS Mus musculus
196 EZH2  
Affinity Capture-MS Homo sapiens
197 DENND4A 10260
Affinity Capture-MS Homo sapiens
198 SRSF7 6432
Affinity Capture-MS Homo sapiens
199 PLEKHA7 144100
Affinity Capture-MS Homo sapiens
200 XRCC6 2547
Proximity Label-MS Homo sapiens
201 SNW1 22938
Affinity Capture-MS Homo sapiens
202 MYO6 4646
Proximity Label-MS Homo sapiens
203 KIF1C 10749
Affinity Capture-MS Homo sapiens
204 MAST3  
Affinity Capture-MS Homo sapiens
205 SSRP1 6749
Affinity Capture-MS Homo sapiens
206 PURA 5813
Co-fractionation Homo sapiens
207 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
208 LUC7L 55692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 NOL9 79707
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 RPL17 6139
Affinity Capture-MS Homo sapiens
211 CDC5L 988
Affinity Capture-MS Homo sapiens
212 EFEMP2 30008
Two-hybrid Homo sapiens
213 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF638 is involved
PathwayEvidenceSource
Adipogenesis IEA Reactome
Developmental Biology IEA Reactome
Transcriptional regulation of white adipocyte differentiation IEA Reactome





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