Gene description for ZNF638
Gene name zinc finger protein 638
Gene symbol ZNF638
Other names/aliases NP220
ZFML
Zfp638
Species Homo sapiens
 Database cross references - ZNF638
ExoCarta ExoCarta_27332
Vesiclepedia VP_27332
Entrez Gene 27332
HGNC 17894
MIM 614349
UniProt Q14966  
 ZNF638 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ZNF638
Molecular Function
    double-stranded DNA binding GO:0003690 TAS
    RNA binding GO:0003723 TAS
    nucleotide binding GO:0000166 IEA
    zinc ion binding GO:0008270 IEA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    RNA splicing GO:0008380 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nuclear speck GO:0016607 IEA
    cytoplasm GO:0005737 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified ZNF638 in exosomes
1
Experiment ID 254
MISEV standards
EM
EV Biophysical techniques
TSG101|FLOT1|CD81
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 258
MISEV standards
EM
EV Biophysical techniques
TSG101|FLOT1|CD81
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 260
MISEV standards
EM
EV Biophysical techniques
TSG101|FLOT1|CD81
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZNF638
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DIPA  
Two-hybrid Homo sapiens
2 SFN 2810
Affinity Capture-MS Homo sapiens
3 KRT19 3880
Two-hybrid Homo sapiens
4 KRT15 3866
Two-hybrid Homo sapiens
5 KRTAP4-12  
Two-hybrid Homo sapiens
6 KIF1BP 26128
Two-hybrid Homo sapiens
7 HOOK2  
Two-hybrid Homo sapiens
8 FHL2 2274
Two-hybrid Homo sapiens
FRET Homo sapiens
9 NDP52  
Two-hybrid Homo sapiens
10 PLSCR1 5359
Two-hybrid Homo sapiens
11 WWP1 11059
Two-hybrid Homo sapiens
12 EFEMP2 30008
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF638 is involved
No pathways found





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