Gene description for FAM53C
Gene name family with sequence similarity 53, member C
Gene symbol FAM53C
Other names/aliases C5orf6
Species Homo sapiens
 Database cross references - FAM53C
ExoCarta ExoCarta_51307
Vesiclepedia VP_51307
Entrez Gene 51307
HGNC 1336
MIM 609372
UniProt Q9NYF3  
 FAM53C identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FAM53C
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein import into nucleus GO:0006606 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
 Experiment description of studies that identified FAM53C in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FAM53C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SFN 2810
Two-hybrid Homo sapiens
3 DYRK1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
5 LIMA1 51474
Affinity Capture-MS Homo sapiens
6 HDAC4  
Affinity Capture-MS Homo sapiens
7 MELK  
Affinity Capture-MS Homo sapiens
8 SYDE1 85360
Affinity Capture-MS Homo sapiens
9 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
10 DENND4C 55667
Affinity Capture-MS Homo sapiens
11 DCLK1 9201
Affinity Capture-MS Homo sapiens
12 KSR1  
Affinity Capture-MS Homo sapiens
13 KIAA1804  
Affinity Capture-MS Homo sapiens
14 TRIM33 51592
Affinity Capture-MS Homo sapiens
15 XPO1 7514
Affinity Capture-MS Homo sapiens
16 RTKN 6242
Affinity Capture-MS Homo sapiens
17 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 DENND1A 57706
Affinity Capture-MS Homo sapiens
19 AGAP1  
Affinity Capture-MS Homo sapiens
20 PPM1H  
Affinity Capture-MS Homo sapiens
21 YWHAE 7531
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
22 CDK16 5127
Affinity Capture-MS Homo sapiens
23 SRGAP2 23380
Affinity Capture-MS Homo sapiens
24 CUL3 8452
Affinity Capture-MS Homo sapiens
25 YWHAZ 7534
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CDC25B 994
Affinity Capture-MS Homo sapiens
27 NF1 4763
Affinity Capture-MS Homo sapiens
28 LRFN1  
Affinity Capture-MS Homo sapiens
29 ANKRD34A  
Affinity Capture-MS Homo sapiens
30 USP21  
Affinity Capture-MS Homo sapiens
31 SH3BP4 23677
Affinity Capture-MS Homo sapiens
32 PLEKHA7 144100
Affinity Capture-MS Homo sapiens
33 NADK 65220
Affinity Capture-MS Homo sapiens
34 FAM110A  
Affinity Capture-MS Homo sapiens
35 GAB2 9846
Affinity Capture-MS Homo sapiens
36 EIF4E2  
Affinity Capture-MS Homo sapiens
37 TESK2  
Affinity Capture-MS Homo sapiens
38 NCK2 8440
Two-hybrid Homo sapiens
39 KIF13B 23303
Affinity Capture-MS Homo sapiens
40 KIF1C 10749
Affinity Capture-MS Homo sapiens
41 SORBS3 10174
Two-hybrid Homo sapiens
42 CBY1  
Affinity Capture-MS Homo sapiens
43 MLLT4 4301
Affinity Capture-MS Homo sapiens
44 DYRK1A 1859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 ZBTB21  
Affinity Capture-MS Homo sapiens
46 GIGYF1  
Affinity Capture-MS Homo sapiens
47 DCAF7 10238
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 KCTD3  
Affinity Capture-MS Homo sapiens
49 RASAL2 9462
Affinity Capture-MS Homo sapiens
50 ZNF638 27332
Affinity Capture-MS Homo sapiens
51 RAB3IP  
Affinity Capture-MS Homo sapiens
52 PLK1 5347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 MEOX2  
Two-hybrid Homo sapiens
54 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 FNTB 2342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 YWHAG 7532
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 FAM110B  
Affinity Capture-MS Homo sapiens
58 MAST3  
Affinity Capture-MS Homo sapiens
59 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
60 TIAM1  
Affinity Capture-MS Homo sapiens
61 PHLDB2 90102
Affinity Capture-MS Homo sapiens
62 MAGI1  
Affinity Capture-MS Homo sapiens
63 TRAF3 7187
Affinity Capture-MS Homo sapiens
64 SRSF12  
Affinity Capture-MS Homo sapiens
65 TBC1D25  
Affinity Capture-MS Homo sapiens
66 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM53C is involved
No pathways found





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