Gene description for PLEKHA7
Gene name pleckstrin homology domain containing, family A member 7
Gene symbol PLEKHA7
Other names/aliases -
Species Homo sapiens
 Database cross references - PLEKHA7
ExoCarta ExoCarta_144100
Vesiclepedia VP_144100
Entrez Gene 144100
HGNC 27049
MIM 612686
UniProt Q6IQ23  
 PLEKHA7 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PLEKHA7
Molecular Function
    protein binding GO:0005515 IPI
    delta-catenin binding GO:0070097 IDA
Biological Process
    cell-cell adhesion mediated by cadherin GO:0044331 IBA
    cell-cell adhesion mediated by cadherin GO:0044331 ISS
    zonula adherens maintenance GO:0045218 IBA
    zonula adherens maintenance GO:0045218 IMP
    pore complex assembly GO:0046931 IBA
    pore complex assembly GO:0046931 IMP
    epithelial cell-cell adhesion GO:0090136 IBA
    epithelial cell-cell adhesion GO:0090136 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    zonula adherens GO:0005915 IBA
    zonula adherens GO:0005915 IDA
    cell junction GO:0030054 IDA
    pore complex GO:0046930 IBA
    pore complex GO:0046930 IMP
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PLEKHA7 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PLEKHA7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HDAC4  
Affinity Capture-MS Homo sapiens
2 OCLN 100506658
Proximity Label-MS Homo sapiens
3 KSR1  
Affinity Capture-MS Homo sapiens
4 GJA1 2697
Proximity Label-MS Homo sapiens
5 PARD3 56288
Proximity Label-MS Homo sapiens
6 FAM228A  
Two-hybrid Homo sapiens
7 CCHCR1  
Two-hybrid Homo sapiens
8 CDC25B 994
Affinity Capture-MS Homo sapiens
9 SRGAP2 23380
Affinity Capture-MS Homo sapiens
10 CAMSAP2  
Affinity Capture-MS Homo sapiens
11 CBY1  
Affinity Capture-MS Homo sapiens
12 EIF4E2  
Affinity Capture-MS Homo sapiens
13 KIF13B 23303
Affinity Capture-MS Homo sapiens
14 PPL 5493
Two-hybrid Homo sapiens
15 MLLT4 4301
Proximity Label-MS Homo sapiens
16 ZBTB21  
Affinity Capture-MS Homo sapiens
17 RASAL2 9462
Affinity Capture-MS Homo sapiens
18 ZNF638 27332
Affinity Capture-MS Homo sapiens
19 PCBD1 5092
Affinity Capture-MS Homo sapiens
20 FBXW7  
Affinity Capture-MS Homo sapiens
21 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TIAM1  
Affinity Capture-MS Homo sapiens
23 YWHAH 7533
Affinity Capture-MS Homo sapiens
24 LRFN1  
Affinity Capture-MS Homo sapiens
25 IGFL2  
Two-hybrid Homo sapiens
26 RAB35 11021
Proximity Label-MS Homo sapiens
27 CCNDBP1 23582
Two-hybrid Homo sapiens
28 KIAA1804  
Affinity Capture-MS Homo sapiens
29 RHOH  
Two-hybrid Homo sapiens
30 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 AGAP1  
Affinity Capture-MS Homo sapiens
32 RDH12 145226
Two-hybrid Homo sapiens
33 CDK16 5127
Affinity Capture-MS Homo sapiens
34 TSPAN33 340348
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ANKRD34A  
Affinity Capture-MS Homo sapiens
36 USP21  
Affinity Capture-MS Homo sapiens
37 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
38 TESK2  
Affinity Capture-MS Homo sapiens
39 LYN 4067
Proximity Label-MS Homo sapiens
40 SOWAHB  
Affinity Capture-MS Homo sapiens
41 CDH1 999
Proximity Label-MS Homo sapiens
42 YWHAE 7531
Affinity Capture-MS Homo sapiens
43 DTX2 113878
Proximity Label-MS Homo sapiens
44 BICD2 23299
Proximity Label-MS Homo sapiens
45 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 FAM110B  
Affinity Capture-MS Homo sapiens
47 KCTD3  
Affinity Capture-MS Homo sapiens
48 CDC14A  
Proximity Label-MS Homo sapiens
49 LIMA1 51474
Affinity Capture-MS Homo sapiens
50 DCLK1 9201
Affinity Capture-MS Homo sapiens
51 CTNNB1 1499
Proximity Label-MS Homo sapiens
52 INPP5E 56623
Affinity Capture-MS Homo sapiens
53 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 EGFR 1956
Affinity Capture-MS Homo sapiens
55 ARF6 382
Proximity Label-MS Homo sapiens
56 NADK 65220
Affinity Capture-MS Homo sapiens
57 SYDE1 85360
Affinity Capture-MS Homo sapiens
58 CDC25C  
Affinity Capture-MS Homo sapiens
59 GIGYF1  
Affinity Capture-MS Homo sapiens
60 CGN  
Affinity Capture-MS Homo sapiens
61 RHOB 388
Proximity Label-MS Homo sapiens
62 CTNNA1 1495
Proximity Label-MS Homo sapiens
63 TSGA10  
Two-hybrid Homo sapiens
64 FLOT1 10211
Proximity Label-MS Homo sapiens
65 FGL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 DENND4C 55667
Affinity Capture-MS Homo sapiens
67 RNF43  
Proximity Label-MS Homo sapiens
68 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
69 GIGYF2 26058
Affinity Capture-MS Homo sapiens
70 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
71 FAM53C 51307
Affinity Capture-MS Homo sapiens
72 GRB2 2885
Two-hybrid Homo sapiens
73 HOMEZ  
Two-hybrid Homo sapiens
74 RTKN 6242
Affinity Capture-MS Homo sapiens
75 NEK6 10783
Two-hybrid Homo sapiens
76 DENND1A 57706
Affinity Capture-MS Homo sapiens
77 PPM1H  
Affinity Capture-MS Homo sapiens
78 SRSF12  
Affinity Capture-MS Homo sapiens
79 LCK 3932
Proximity Label-MS Homo sapiens
80 LATS2 26524
Proximity Label-MS Homo sapiens
81 DNMBP 23268
Affinity Capture-MS Homo sapiens
82 C11orf52 91894
Proximity Label-MS Homo sapiens
83 NF1 4763
Affinity Capture-MS Homo sapiens
84 STMN3  
Two-hybrid Homo sapiens
85 EPHA2 1969
Proximity Label-MS Homo sapiens
86 B9D2 80776
Two-hybrid Homo sapiens
87 KRAS 3845
Proximity Label-MS Homo sapiens
88 IGFBP6 3489
Two-hybrid Homo sapiens
89 MAST3  
Affinity Capture-MS Homo sapiens
90 HSF2BP  
Two-hybrid Homo sapiens
91 MAGI1  
Affinity Capture-MS Homo sapiens
92 S100A2 6273
Affinity Capture-MS Homo sapiens
93 USP20  
Affinity Capture-MS Homo sapiens
94 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PLEKHA7 is involved
No pathways found





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