Gene description for SYDE1
Gene name synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Gene symbol SYDE1
Other names/aliases 7h3
Species Homo sapiens
 Database cross references - SYDE1
ExoCarta ExoCarta_85360
Vesiclepedia VP_85360
Entrez Gene 85360
HGNC 25824
UniProt Q6ZW31  
 SYDE1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SYDE1
Molecular Function
    GTPase activator activity GO:0005096 IBA
    GTPase activator activity GO:0005096 IDA
    GTPase activator activity GO:0005096 IMP
    GTPase activator activity GO:0005096 ISS
    GTPase regulator activity GO:0030695 IDA
    GTPase regulator activity GO:0030695 IMP
Biological Process
    signal transduction GO:0007165 IEA
    cell migration GO:0016477 IBA
    cell migration GO:0016477 IDA
    cell migration GO:0016477 IMP
    actin cytoskeleton organization GO:0030036 IDA
    regulation of Ras protein signal transduction GO:0046578 IBA
    regulation of cytoskeleton organization GO:0051493 IMP
    activation of GTPase activity GO:0090630 ISS
    positive regulation of trophoblast cell migration GO:1901165 IMP
Subcellular Localization
    synaptic membrane GO:0097060 IBA
 Experiment description of studies that identified SYDE1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SYDE1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 HDAC4  
Affinity Capture-MS Homo sapiens
3 GIGYF1  
Affinity Capture-MS Homo sapiens
4 OCLN 100506658
Proximity Label-MS Homo sapiens
5 KSR1  
Affinity Capture-MS Homo sapiens
6 SH3BP4 23677
Affinity Capture-MS Homo sapiens
7 YWHAE 7531
Affinity Capture-MS Homo sapiens
8 NAV1 89796
Affinity Capture-MS Homo sapiens
9 CDC25B 994
Affinity Capture-MS Homo sapiens
10 SRGAP2 23380
Affinity Capture-MS Homo sapiens
11 PYCR1 5831
Affinity Capture-MS Homo sapiens
12 XRN2 22803
Affinity Capture-MS Homo sapiens
13 KPNA2 3838
Affinity Capture-MS Homo sapiens
14 CAMSAP2  
Affinity Capture-MS Homo sapiens
15 CBY1  
Affinity Capture-MS Homo sapiens
16 APBB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 AZGP1 563
Affinity Capture-MS Homo sapiens
18 EIF4E2  
Affinity Capture-MS Homo sapiens
19 APP 351
Affinity Capture-MS Homo sapiens
20 KIF13B 23303
Affinity Capture-MS Homo sapiens
21 MLLT4 4301
Affinity Capture-MS Homo sapiens
22 ZBTB21  
Affinity Capture-MS Homo sapiens
23 APBB2  
Affinity Capture-MS Homo sapiens
24 ACTR3 10096
Proximity Label-MS Homo sapiens
25 RASAL2 9462
Affinity Capture-MS Homo sapiens
26 ZNF638 27332
Affinity Capture-MS Homo sapiens
27 POLR2I 5438
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 TIAM1  
Affinity Capture-MS Homo sapiens
29 PRDX2 7001
Affinity Capture-MS Homo sapiens
30 HMGA2 8091
Affinity Capture-MS Homo sapiens
31 KPRP 448834
Affinity Capture-MS Homo sapiens
32 PTPN14 5784
Affinity Capture-MS Homo sapiens
33 LRFN1  
Affinity Capture-MS Homo sapiens
34 KIAA1804  
Affinity Capture-MS Homo sapiens
35 MELK  
Affinity Capture-MS Homo sapiens
36 AGAP1  
Affinity Capture-MS Homo sapiens
37 PHLDB2 90102
Affinity Capture-MS Homo sapiens
38 CDK16 5127
Affinity Capture-MS Homo sapiens
39 Arhgap28  
Affinity Capture-MS Mus musculus
40 DSG1 1828
Affinity Capture-MS Homo sapiens
41 ANKRD34A  
Affinity Capture-MS Homo sapiens
42 USP21  
Affinity Capture-MS Homo sapiens
43 KLHDC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 FAM110A  
Affinity Capture-MS Homo sapiens
45 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
46 TESK2  
Affinity Capture-MS Homo sapiens
47 APLP2 334
Affinity Capture-MS Homo sapiens
48 FAM110B  
Affinity Capture-MS Homo sapiens
49 KCTD3  
Affinity Capture-MS Homo sapiens
50 LIMA1 51474
Affinity Capture-MS Homo sapiens
51 DCLK1 9201
Affinity Capture-MS Homo sapiens
52 XPO1 7514
Affinity Capture-MS Homo sapiens
53 HSPE1 3336
Affinity Capture-MS Homo sapiens
54 WDR33 55339
Affinity Capture-MS Homo sapiens
55 TYW3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 POLR2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 NADK 65220
Affinity Capture-MS Homo sapiens
58 PYCR2 29920
Affinity Capture-MS Homo sapiens
59 POLR2A 5430
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 CALM1 801
Affinity Capture-MS Homo sapiens
61 PLEKHA5 54477
Affinity Capture-MS Homo sapiens
62 CDC25C  
Affinity Capture-MS Homo sapiens
63 PHF6  
Affinity Capture-MS Homo sapiens
64 CGN  
Affinity Capture-MS Homo sapiens
65 TBC1D25  
Affinity Capture-MS Homo sapiens
66 RPH3A 22895
Affinity Capture-MS Homo sapiens
67 DENND4C 55667
Affinity Capture-MS Homo sapiens
68 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
69 NUDT21 11051
Affinity Capture-MS Homo sapiens
70 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
71 FAM53C 51307
Affinity Capture-MS Homo sapiens
72 POLR2J  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 RTKN 6242
Affinity Capture-MS Homo sapiens
74 RBM25 58517
Affinity Capture-MS Homo sapiens
75 DENND1A 57706
Affinity Capture-MS Homo sapiens
76 PPM1H  
Affinity Capture-MS Homo sapiens
77 RIF1  
Affinity Capture-MS Homo sapiens
78 SRSF12  
Affinity Capture-MS Homo sapiens
79 PRSS2 5645
Affinity Capture-MS Homo sapiens
80 RAB3IP  
Affinity Capture-MS Homo sapiens
81 RPAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 C1orf35  
Affinity Capture-MS Homo sapiens
83 EDC3 80153
Affinity Capture-MS Homo sapiens
84 GAB2 9846
Affinity Capture-MS Homo sapiens
85 NF1 4763
Affinity Capture-MS Homo sapiens
86 CDK9 1025
Affinity Capture-MS Homo sapiens
87 PLEKHA7 144100
Affinity Capture-MS Homo sapiens
88 KLHL22 84861
Affinity Capture-MS Homo sapiens
89 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 KIF1C 10749
Affinity Capture-MS Homo sapiens
91 MAST3  
Affinity Capture-MS Homo sapiens
92 MAGI1  
Affinity Capture-MS Homo sapiens
93 LURAP1  
Affinity Capture-MS Homo sapiens
94 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
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