Gene description for NF1
Gene name neurofibromin 1
Gene symbol NF1
Other names/aliases NFNS
VRNF
WSS
Species Homo sapiens
 Database cross references - NF1
ExoCarta ExoCarta_4763
Vesiclepedia VP_4763
Entrez Gene 4763
HGNC 7765
MIM 613113
UniProt P21359  
 NF1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for NF1
Molecular Function
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
    phosphatidylethanolamine binding GO:0008429 IDA
    phosphatidylcholine binding GO:0031210 IDA
Biological Process
    MAPK cascade GO:0000165 ISS
    angiogenesis GO:0001525 IEA
    osteoblast differentiation GO:0001649 ISS
    metanephros development GO:0001656 ISS
    response to hypoxia GO:0001666 ISS
    liver development GO:0001889 ISS
    endothelial cell proliferation GO:0001935 IEA
    negative regulation of endothelial cell proliferation GO:0001937 IMP
    negative regulation of endothelial cell proliferation GO:0001937 IMP
    positive regulation of endothelial cell proliferation GO:0001938 IEA
    regulation of cell-matrix adhesion GO:0001952 ISS
    negative regulation of cell-matrix adhesion GO:0001953 IEA
    negative regulation of leukocyte migration GO:0002686 IEA
    protein import into nucleus GO:0006606 IEA
    cell communication GO:0007154 ISS
    Ras protein signal transduction GO:0007265 ISS
    neuroblast proliferation GO:0007405 IEA
    negative regulation of neuroblast proliferation GO:0007406 ISS
    brain development GO:0007420 ISS
    peripheral nervous system development GO:0007422 ISS
    heart development GO:0007507 ISS
    skeletal muscle tissue development GO:0007519 IEA
    visual learning GO:0008542 ISS
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IEA
    regulation of gene expression GO:0010468 IEA
    negative regulation of Schwann cell proliferation GO:0010626 IEA
    Schwann cell proliferation GO:0014010 IEA
    Schwann cell development GO:0014044 ISS
    negative regulation of angiogenesis GO:0016525 IEA
    Rac protein signal transduction GO:0016601 IEA
    spinal cord development GO:0021510 ISS
    amygdala development GO:0021764 IEA
    forebrain astrocyte development GO:0021897 ISS
    neural tube development GO:0021915 IEA
    cerebral cortex development GO:0021987 ISS
    myelination in peripheral nervous system GO:0022011 ISS
    actin cytoskeleton organization GO:0030036 ISS
    extracellular matrix organization GO:0030198 ISS
    collagen fibril organization GO:0030199 ISS
    osteoclast differentiation GO:0030316 IEA
    adrenal gland development GO:0030325 ISS
    negative regulation of cell migration GO:0030336 IMP
    regulation of synaptic transmission, GABAergic GO:0032228 IEA
    mast cell apoptotic process GO:0033024 IEA
    positive regulation of mast cell apoptotic process GO:0033027 IEA
    cellular response to heat GO:0034605 IEA
    negative regulation of Rac protein signal transduction GO:0035021 IEA
    Schwann cell migration GO:0036135 IEA
    wound healing GO:0042060 ISS
    negative regulation of protein import into nucleus GO:0042308 IEA
    positive regulation of apoptotic process GO:0043065 ISS
    negative regulation of MAPK cascade GO:0043409 IMP
    negative regulation of MAPK cascade GO:0043409 ISS
    pigmentation GO:0043473 ISS
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 ISS
    positive regulation of neuron apoptotic process GO:0043525 ISS
    regulation of blood vessel endothelial cell migration GO:0043535 IMP
    positive regulation of GTPase activity GO:0043547 IDA
    positive regulation of GTPase activity GO:0043547 IMP
    regulation of bone resorption GO:0045124 ISS
    negative regulation of osteoclast differentiation GO:0045671 IEA
    regulation of glial cell differentiation GO:0045685 ISS
    regulation of angiogenesis GO:0045765 IMP
    negative regulation of Ras protein signal transduction GO:0046580 IEA
    negative regulation of neurotransmitter secretion GO:0046929 IEA
    fibroblast proliferation GO:0048144 IEA
    negative regulation of fibroblast proliferation GO:0048147 ISS
    regulation of long-term neuronal synaptic plasticity GO:0048169 IEA
    sympathetic nervous system development GO:0048485 ISS
    camera-type eye morphogenesis GO:0048593 ISS
    oligodendrocyte differentiation GO:0048709 IEA
    negative regulation of astrocyte differentiation GO:0048712 IEA
    negative regulation of oligodendrocyte differentiation GO:0048715 ISS
    smooth muscle tissue development GO:0048745 ISS
    hair follicle maturation GO:0048820 IEA
    artery morphogenesis GO:0048844 ISS
    forebrain morphogenesis GO:0048853 ISS
    cognition GO:0050890 IMP
    neuron apoptotic process GO:0051402 IEA
    long-term synaptic potentiation GO:0060291 IEA
    gamma-aminobutyric acid secretion, neurotransmission GO:0061534 IEA
    glutamate secretion, neurotransmission GO:0061535 IEA
    regulation of ERK1 and ERK2 cascade GO:0070372 IEA
    mast cell proliferation GO:0070662 IEA
    negative regulation of mast cell proliferation GO:0070667 IEA
    stem cell proliferation GO:0072089 IEA
    extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IEA
    myeloid leukocyte migration GO:0097529 IEA
    observational learning GO:0098597 IEA
    regulation of postsynapse organization GO:0099175 IEA
    negative regulation of Schwann cell migration GO:1900148 IEA
    regulation of long-term synaptic potentiation GO:1900271 IEA
    positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IEA
    vascular associated smooth muscle cell migration GO:1904738 IEA
    negative regulation of vascular associated smooth muscle cell migration GO:1904753 IEA
    vascular associated smooth muscle cell proliferation GO:1990874 IEA
    negative regulation of stem cell proliferation GO:2000647 IEA
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IEA
Subcellular Localization
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IEA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 HDA
    axon GO:0030424 IDA
    dendrite GO:0030425 IDA
    presynapse GO:0098793 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified NF1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGOLN2 10618
Affinity Capture-MS Homo sapiens
2 TOR4A 54863
Negative Genetic Homo sapiens
3 HDAC4  
Affinity Capture-MS Homo sapiens
4 USH1G  
Negative Genetic Homo sapiens
5 KSR1  
Affinity Capture-MS Homo sapiens
6 RALGPS2 55103
Affinity Capture-MS Homo sapiens
7 ATG9A 79065
Negative Genetic Homo sapiens
8 LLGL1 3996
Negative Genetic Homo sapiens
9 USP48  
Negative Genetic Homo sapiens
10 HCST  
Affinity Capture-MS Homo sapiens
11 UBE2T  
Negative Genetic Homo sapiens
12 NAV1 89796
Affinity Capture-MS Homo sapiens
13 HRAS 3265
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
14 CDC25B 994
Affinity Capture-MS Homo sapiens
15 SRGAP2 23380
Affinity Capture-MS Homo sapiens
16 CAMSAP2  
Affinity Capture-MS Homo sapiens
17 CBY1  
Affinity Capture-MS Homo sapiens
18 USP21  
Affinity Capture-MS Homo sapiens
19 NDUFB6 4712
Negative Genetic Homo sapiens
20 EIF4E2  
Affinity Capture-MS Homo sapiens
21 APP 351
Affinity Capture-Western Homo sapiens
22 KIF13B 23303
Affinity Capture-MS Homo sapiens
23 TOP2A 7153
Synthetic Lethality Homo sapiens
24 MARK2 2011
Negative Genetic Homo sapiens
25 DYRK1A 1859
Affinity Capture-MS Homo sapiens
26 ZBTB21  
Affinity Capture-MS Homo sapiens
27 RASAL2 9462
Affinity Capture-MS Homo sapiens
28 ZNF638 27332
Affinity Capture-MS Homo sapiens
29 FAM174A 345757
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PRC1 9055
Affinity Capture-MS Homo sapiens
31 NPM1 4869
Cross-Linking-MS (XL-MS) Homo sapiens
32 EVI2A  
Affinity Capture-MS Homo sapiens
33 GAB2 9846
Affinity Capture-MS Homo sapiens
34 TIAM1  
Affinity Capture-MS Homo sapiens
35 SEMA4C 54910
Affinity Capture-MS Homo sapiens
36 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PRKRA 8575
Negative Genetic Homo sapiens
38 TACSTD2 4070
Affinity Capture-MS Homo sapiens
39 DGCR2 9993
Affinity Capture-MS Homo sapiens
40 PTPN14 5784
Affinity Capture-MS Homo sapiens
41 YWHAH 7533
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
42 LRFN1  
Affinity Capture-MS Homo sapiens
43 NSFL1C 55968
Affinity Capture-Western Homo sapiens
44 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 FAF2 23197
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
46 BFAR  
Negative Genetic Homo sapiens
47 KIAA1804  
Affinity Capture-MS Homo sapiens
48 KIF14 9928
Affinity Capture-MS Homo sapiens
49 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SRSF6 6431
Negative Genetic Homo sapiens
51 AGAP1  
Affinity Capture-MS Homo sapiens
52 PFN1 5216
Proximity Label-MS Homo sapiens
53 PTGES2 80142
Affinity Capture-MS Homo sapiens
54 VSIG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PHLDB2 90102
Affinity Capture-MS Homo sapiens
56 EIF2AK3  
Negative Genetic Homo sapiens
57 CDK16 5127
Affinity Capture-MS Homo sapiens
58 BRIP1  
Negative Genetic Homo sapiens
59 EBNA1BP2 10969
Negative Genetic Homo sapiens
60 TYMS 7298
Negative Genetic Homo sapiens
61 C19orf38  
Affinity Capture-MS Homo sapiens
62 ANKRD34A  
Affinity Capture-MS Homo sapiens
63 CTDP1 9150
Affinity Capture-MS Homo sapiens
64 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
65 COPG1 22820
Negative Genetic Homo sapiens
66 TESK2  
Affinity Capture-MS Homo sapiens
67 LYN 4067
Proximity Label-MS Homo sapiens
68 MCAM 4162
Proximity Label-MS Homo sapiens
69 VSIG4  
Affinity Capture-MS Homo sapiens
70 SMARCA4 6597
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
71 IL2RA  
Affinity Capture-MS Homo sapiens
72 YAP1 10413
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
73 VCP 7415
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
74 LPIN3 64900
Affinity Capture-MS Homo sapiens
75 DCTN1 1639
Negative Genetic Homo sapiens
76 MOGS 7841
Negative Genetic Homo sapiens
77 ARRDC3 57561
Affinity Capture-MS Homo sapiens
78 PML 5371
Co-localization Homo sapiens
79 FAM110B  
Affinity Capture-MS Homo sapiens
80 ITFG3 83986
Affinity Capture-MS Homo sapiens
81 TMEM261  
Negative Genetic Homo sapiens
82 TANC2  
Affinity Capture-MS Homo sapiens
83 KCTD3  
Affinity Capture-MS Homo sapiens
84 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 SYNGR3  
Negative Genetic Homo sapiens
86 TIRAP  
Affinity Capture-MS Homo sapiens
87 C20orf173  
Negative Genetic Homo sapiens
88 PMVK 10654
Negative Genetic Homo sapiens
89 LIMA1 51474
Affinity Capture-MS Homo sapiens
90 EFNA4  
Affinity Capture-MS Homo sapiens
91 HADHB 3032
Negative Genetic Homo sapiens
92 DCLK1 9201
Affinity Capture-MS Homo sapiens
93 CTSK 1513
Negative Genetic Homo sapiens
94 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 PTEN 5728
Positive Genetic Homo sapiens
96 ARRDC4  
Affinity Capture-MS Homo sapiens
97 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 SIRT7  
Affinity Capture-MS Homo sapiens
99 LRRC25  
Affinity Capture-MS Homo sapiens
100 OSBPL6  
Affinity Capture-MS Homo sapiens
101 INPP5E 56623
Affinity Capture-MS Homo sapiens
102 CD274 29126
Affinity Capture-MS Homo sapiens
103 TRAF6 7189
Affinity Capture-MS Homo sapiens
104 NR3C1 2908
Proximity Label-MS Homo sapiens
105 ECHDC2 55268
Negative Genetic Homo sapiens
106 EGFR 1956
Affinity Capture-MS Homo sapiens
107 TOP3A  
Synthetic Lethality Homo sapiens
108 NADK 65220
Affinity Capture-MS Homo sapiens
109 KIAA1524 57650
Negative Genetic Homo sapiens
110 POLR2A 5430
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
111 SUZ12  
Negative Genetic Homo sapiens
112 SDC2 6383
Two-hybrid Homo sapiens
113 SYDE1 85360
Affinity Capture-MS Homo sapiens
114 NXF1 10482
Affinity Capture-RNA Homo sapiens
115 CD226 10666
Affinity Capture-MS Homo sapiens
116 CDC25C  
Affinity Capture-MS Homo sapiens
117 C3orf18  
Affinity Capture-MS Homo sapiens
118 PTPN13 5783
Affinity Capture-MS Homo sapiens
119 GIGYF1  
Affinity Capture-MS Homo sapiens
120 TOP1 7150
Synthetic Lethality Homo sapiens
121 KAT5  
Negative Genetic Homo sapiens
122 CGN  
Affinity Capture-MS Homo sapiens
123 DDRGK1 65992
Affinity Capture-MS Homo sapiens
124 RHOB 388
Proximity Label-MS Homo sapiens
125 P4HA3 283208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 SHBG 6462
Negative Genetic Homo sapiens
127 TNFSF13B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 CDK10  
Negative Genetic Homo sapiens
129 EFNB2 1948
Affinity Capture-MS Homo sapiens
130 CDHR2 54825
Affinity Capture-MS Homo sapiens
131 FLOT1 10211
Proximity Label-MS Homo sapiens
132 CCDC8  
Affinity Capture-MS Homo sapiens
133 STUB1 10273
Negative Genetic Homo sapiens
134 DENND4C 55667
Affinity Capture-MS Homo sapiens
135 NOSIP 51070
Co-fractionation Homo sapiens
136 GYPA  
Affinity Capture-MS Homo sapiens
137 SH3RF3  
Affinity Capture-MS Homo sapiens
138 PSMC3IP  
Negative Genetic Homo sapiens
139 GIGYF2 26058
Affinity Capture-MS Homo sapiens
140 UIMC1  
Negative Genetic Homo sapiens
141 FASN 2194
Negative Genetic Homo sapiens
142 CNKSR2 22866
Negative Genetic Homo sapiens
143 STARD13 90627
Affinity Capture-MS Homo sapiens
144 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
145 SIRT6  
Affinity Capture-MS Homo sapiens
146 FAM53C 51307
Affinity Capture-MS Homo sapiens
147 G6PC  
Negative Genetic Homo sapiens
148 FBXW11  
Negative Genetic Homo sapiens
149 RTKN 6242
Affinity Capture-MS Homo sapiens
150 OPALIN  
Affinity Capture-MS Homo sapiens
151 DENND1A 57706
Affinity Capture-MS Homo sapiens
152 PPM1H  
Affinity Capture-MS Homo sapiens
153 CA4 762
Negative Genetic Homo sapiens
154 JTB 10899
Negative Genetic Homo sapiens
155 SRSF12  
Affinity Capture-MS Homo sapiens
156 LCK 3932
Proximity Label-MS Homo sapiens
157 WRAP53  
Negative Genetic Homo sapiens
158 EFNB1 1947
Affinity Capture-MS Homo sapiens
159 MAGI1  
Affinity Capture-MS Homo sapiens
160 SLAMF1 6504
Affinity Capture-MS Homo sapiens
161 MKI67  
Affinity Capture-MS Homo sapiens
162 HTR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
163 CD80 941
Affinity Capture-MS Homo sapiens
164 MIF 4282
Affinity Capture-MS Homo sapiens
165 HLA-DPA1  
Affinity Capture-MS Homo sapiens
166 DENND4A 10260
Affinity Capture-MS Homo sapiens
167 C16orf72 29035
Negative Genetic Homo sapiens
168 NDUFC1  
Negative Genetic Homo sapiens
169 PRDX1 5052
Negative Genetic Homo sapiens
170 PLEKHA7 144100
Affinity Capture-MS Homo sapiens
171 RPRD1B 58490
Negative Genetic Homo sapiens
172 TPST2 8459
Affinity Capture-MS Homo sapiens
173 ZUFSP 221302
Affinity Capture-MS Homo sapiens
174 KRAS 3845
Proximity Label-MS Homo sapiens
175 FAM106A  
Negative Genetic Homo sapiens
176 KIF1C 10749
Affinity Capture-MS Homo sapiens
177 MAST3  
Affinity Capture-MS Homo sapiens
178 PTRF 284119
Negative Genetic Homo sapiens
179 SYT12  
Negative Genetic Homo sapiens
180 RPA3 6119
Proximity Label-MS Homo sapiens
181 CCDC144A  
Negative Genetic Homo sapiens
182 CDC5L 988
Affinity Capture-MS Homo sapiens
183 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here