Gene description for CDHR2
Gene name cadherin-related family member 2
Gene symbol CDHR2
Other names/aliases PCDH24
PCLKC
Species Homo sapiens
 Database cross references - CDHR2
ExoCarta ExoCarta_54825
Entrez Gene 54825
HGNC 18231
UniProt Q9BYE9  
 CDHR2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 25890246    
Urine 19056867    
 Gene ontology annotations for CDHR2
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    cell adhesion GO:0007155 IDA
    negative regulation of cell growth GO:0030308 IDA
Subcellular Localization
    apical plasma membrane GO:0016324 IEA
    cell junction GO:0030054 IEA
    integral component of membrane GO:0016021 IDA
    extracellular exosome GO:0070062 IDA
    brush border GO:0005903 IDA
 Experiment description of studies that identified CDHR2 in exosomes
1
Experiment ID 283
ISEV standards
CEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81|EpCAM
EV Membrane markers
EV Negative markers
DLS
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors Xu R, Greening DW, Rai A, Ji H, Simpson RJ.
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CDHR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAST2  
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
View the network image/svg+xml
 Pathways in which CDHR2 is involved
No pathways found





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