Gene description for MOGS
Gene name mannosyl-oligosaccharide glucosidase
Gene symbol MOGS
Other names/aliases CDG2B
CWH41
DER7
GCS1
Species Homo sapiens
 Database cross references - MOGS
ExoCarta ExoCarta_7841
Entrez Gene 7841
HGNC 24862
MIM 601336
UniProt Q13724  
 MOGS identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Saliva 19199708    
Squamous carcinoma cells 20124223    
Urine 19056867    
 Gene ontology annotations for MOGS
Molecular Function
    mannosyl-oligosaccharide glucosidase activity GO:0004573 IEA
    glucosidase activity GO:0015926 TAS
Biological Process
    protein N-linked glycosylation via asparagine GO:0018279 TAS
    protein N-linked glycosylation GO:0006487 TAS
    protein folding GO:0006457 TAS
    oligosaccharide metabolic process GO:0009311 IEA
    post-translational protein modification GO:0043687 TAS
    cellular protein metabolic process GO:0044267 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    membrane GO:0016020 IDA
    endoplasmic reticulum GO:0005783 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified MOGS in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
3
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MOGS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHGB  
Two-hybrid Homo sapiens
View the network image/svg+xml



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