Gene description for MORC3
Gene name MORC family CW-type zinc finger 3
Gene symbol MORC3
Other names/aliases NXP2
ZCW5
ZCWCC3
Species Homo sapiens
 Database cross references - MORC3
ExoCarta ExoCarta_23515
Vesiclepedia VP_23515
Entrez Gene 23515
HGNC 23572
MIM 610078
UniProt Q14149  
 MORC3 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MORC3
Molecular Function
    DNA binding GO:0003677 IDA
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ATP hydrolysis activity GO:0016887 IEA
    protein-macromolecule adaptor activity GO:0030674 IDA
    methylated histone binding GO:0035064 IBA
    methylated histone binding GO:0035064 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    protein phosphorylation GO:0006468 IDA
    post-embryonic development GO:0009791 IEA
    peptidyl-serine phosphorylation GO:0018105 IDA
    negative regulation of interferon-beta production GO:0032688 IDA
    negative regulation of fibroblast proliferation GO:0048147 IDA
    protein stabilization GO:0050821 IDA
    maintenance of protein location in nucleus GO:0051457 IDA
    maintenance of protein location in nucleus GO:0051457 IMP
    antiviral innate immune response GO:0140374 IDA
    positive regulation of cellular senescence GO:2000774 IDA
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nuclear matrix GO:0016363 IEA
    PML body GO:0016605 IBA
    PML body GO:0016605 IDA
    PML body GO:0016605 IDA
 Experiment description of studies that identified MORC3 in sEVs
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MORC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DEPDC1  
Affinity Capture-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 PARP1 142
Proximity Label-MS Homo sapiens
4 RDH10 157506
Affinity Capture-MS Homo sapiens
5 HIST1H3A 8350
Proximity Label-MS Homo sapiens
6 RAD23A 5886
Affinity Capture-MS Homo sapiens
7 DOCK8 81704
Affinity Capture-MS Homo sapiens
8 RPA2 6118
Proximity Label-MS Homo sapiens
9 CUL3 8452
Affinity Capture-MS Homo sapiens
10 UBC 7316
Reconstituted Complex Homo sapiens
11 SYNE2 23224
Affinity Capture-MS Homo sapiens
12 KPNA2 3838
Two-hybrid Homo sapiens
13 FAM9C  
Affinity Capture-MS Homo sapiens
14 GDF15 9518
Affinity Capture-MS Homo sapiens
15 HTT 3064
Affinity Capture-MS Homo sapiens
16 C6orf141  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 SNTB1 6641
Affinity Capture-MS Homo sapiens
18 RPA3 6119
Proximity Label-MS Homo sapiens
19 DYNLRB1 83658
Proximity Label-MS Homo sapiens
20 MOGS 7841
Affinity Capture-MS Homo sapiens
21 TRIB1 10221
Affinity Capture-MS Homo sapiens
22 ROR1 4919
Affinity Capture-MS Homo sapiens
23 Dynll1 56455
Affinity Capture-MS Mus musculus
24 DYNLL2 140735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SSRP1 6749
Affinity Capture-MS Homo sapiens
26 PML 5371
Affinity Capture-MS Homo sapiens
27 CRIPT 9419
Affinity Capture-MS Homo sapiens
28 DYNLL1 8655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MORC3 is involved
No pathways found





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