Gene description for RDH10
Gene name retinol dehydrogenase 10 (all-trans)
Gene symbol RDH10
Other names/aliases SDR16C4
Species Homo sapiens
 Database cross references - RDH10
ExoCarta ExoCarta_157506
Entrez Gene 157506
HGNC 19975
MIM 607599
UniProt Q8IZV5  
 RDH10 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RDH10
Molecular Function
    NADP-retinol dehydrogenase activity GO:0052650 IEA
    retinol dehydrogenase activity GO:0004745 IDA
Biological Process
    visual perception GO:0007601 IDA
    retinoid metabolic process GO:0001523 TAS
    retinoic acid biosynthetic process GO:0002138 IEA
    oxidation-reduction process GO:0055114 IEA
    bud elongation involved in lung branching GO:0060449 IEA
    retinol metabolic process GO:0042572 IEA
    in utero embryonic development GO:0001701 IEA
    neural crest cell development GO:0014032 IEA
    retinal metabolic process GO:0042574 IDA
    gonad development GO:0008406 IEA
    ear development GO:0043583 IEA
    metanephros development GO:0001656 IEA
    nose development GO:0043584 IEA
    primary lung bud formation GO:0060431 IEA
    embryonic viscerocranium morphogenesis GO:0048703 IEA
    embryonic forelimb morphogenesis GO:0035115 IEA
    embryonic camera-type eye development GO:0031076 IEA
    phototransduction, visible light GO:0007603 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IDA
    nucleus GO:0005634 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    cytoplasm GO:0005737 IDA
    cell body GO:0044297 IEA
 Experiment description of studies that identified RDH10 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RDH10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RDH10 is involved
PathwayEvidenceSource
RA biosynthesis pathway TAS Reactome
The canonical retinoid cycle in rods (twilight vision) TAS Reactome





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