Gene description for PMVK
Gene name phosphomevalonate kinase
Gene symbol PMVK
Other names/aliases HUMPMKI
PMK
PMKA
PMKASE
Species Homo sapiens
 Database cross references - PMVK
ExoCarta ExoCarta_10654
Vesiclepedia VP_10654
Entrez Gene 10654
HGNC 9141
MIM 607622
UniProt Q15126  
 PMVK identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for PMVK
Molecular Function
    phosphomevalonate kinase activity GO:0004631 IBA
    phosphomevalonate kinase activity GO:0004631 IDA
    phosphomevalonate kinase activity GO:0004631 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
Biological Process
    cholesterol biosynthetic process GO:0006695 IBA
    cholesterol biosynthetic process GO:0006695 IDA
    cholesterol biosynthetic process GO:0006695 TAS
    sterol biosynthetic process GO:0016126 IDA
    isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287 IBA
    isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287 IEA
    response to cholesterol GO:0070723 IEP
Subcellular Localization
    peroxisome GO:0005777 IDA
    peroxisome GO:0005777 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PMVK in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PMVK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF559-ZNF177 100529215
Two-hybrid Homo sapiens
2 PTPRF 5792
Co-fractionation Homo sapiens
3 GSX1  
Affinity Capture-MS Homo sapiens
4 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
5 NUP88 4927
Affinity Capture-MS Homo sapiens
6 PSAP 5660
Affinity Capture-MS Homo sapiens
7 PRKY  
Affinity Capture-MS Homo sapiens
8 PSG11  
Affinity Capture-MS Homo sapiens
9 DSG1 1828
Affinity Capture-MS Homo sapiens
10 PKP1 5317
Affinity Capture-MS Homo sapiens
11 CTSV 1515
Affinity Capture-MS Homo sapiens
12 SDHA 6389
Affinity Capture-MS Homo sapiens
13 CENPW  
Affinity Capture-MS Homo sapiens
14 SCNM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SSB 6741
Affinity Capture-MS Homo sapiens
16 NF2 4771
Negative Genetic Homo sapiens
17 KCTD14 65987
Affinity Capture-MS Homo sapiens
18 MBD5 55777
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 RASGRF2  
Affinity Capture-MS Homo sapiens
20 GOT1 2805
Affinity Capture-MS Homo sapiens
21 SLC25A35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CENPH  
Affinity Capture-MS Homo sapiens
23 CCT8L2  
Affinity Capture-MS Homo sapiens
24 FGB 2244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 S100A7 6278
Affinity Capture-MS Homo sapiens
26 PLBD1 79887
Affinity Capture-MS Homo sapiens
27 NPPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 FSD1  
Affinity Capture-MS Homo sapiens
29 C4orf26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ZC3HC1  
Affinity Capture-MS Homo sapiens
31 SFN 2810
Affinity Capture-MS Homo sapiens
32 TBPL1 9519
Affinity Capture-MS Homo sapiens
33 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
34 METTL21B  
Affinity Capture-MS Homo sapiens
35 DDIT4L  
Two-hybrid Homo sapiens
36 MKI67  
Affinity Capture-MS Homo sapiens
37 SOX2  
Affinity Capture-MS Homo sapiens
38 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
39 NKD2 85409
Affinity Capture-MS Homo sapiens
40 PITPNA 5306
Affinity Capture-MS Homo sapiens
41 ZNF177  
Two-hybrid Homo sapiens
42 NF1 4763
Negative Genetic Homo sapiens
43 LSM7  
Affinity Capture-MS Homo sapiens
44 ARL6IP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 NCAPH 23397
Affinity Capture-MS Homo sapiens
46 UBFD1 56061
Co-fractionation Homo sapiens
47 KRTAP3-2  
Affinity Capture-MS Homo sapiens
48 CCR1  
Affinity Capture-MS Homo sapiens
49 COG3 83548
Affinity Capture-MS Homo sapiens
50 LRRC29  
Affinity Capture-MS Homo sapiens
51 GTF2E2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 SARAF  
Affinity Capture-MS Homo sapiens
53 EGFR 1956
Negative Genetic Homo sapiens
54 PINK1  
Affinity Capture-MS Homo sapiens
55 COMT 1312
Co-fractionation Homo sapiens
56 SLC25A32 81034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 BAP1 8314
Negative Genetic Homo sapiens
58 BLMH 642
Affinity Capture-MS Homo sapiens
59 WDR92 116143
Co-fractionation Homo sapiens
60 LGI1  
Affinity Capture-MS Homo sapiens
61 DUSP14 11072
Affinity Capture-MS Homo sapiens
62 DSC1 1823
Affinity Capture-MS Homo sapiens
63 MPDU1 9526
Affinity Capture-MS Homo sapiens
64 RDH12 145226
Affinity Capture-MS Homo sapiens
65 PIP 5304
Affinity Capture-MS Homo sapiens
66 KRAS 3845
Synthetic Lethality Homo sapiens
67 SNRNP27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 FYTTD1  
Affinity Capture-MS Homo sapiens
69 UPK1A 11045
Affinity Capture-MS Homo sapiens
70 SLC37A4 2542
Affinity Capture-MS Homo sapiens
71 SETD3 84193
Affinity Capture-MS Homo sapiens
72 MLF2 8079
Affinity Capture-MS Homo sapiens
73 MAPKBP1  
Affinity Capture-MS Homo sapiens
74 HSPB8 26353
Affinity Capture-MS Homo sapiens
75 RGS20 8601
Affinity Capture-MS Homo sapiens
76 UBXN6 80700
Affinity Capture-MS Homo sapiens
77 VPS25 84313
Affinity Capture-MS Homo sapiens
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