Gene description for ZNF559-ZNF177
Gene name ZNF559-ZNF177 readthrough
Gene symbol ZNF559-ZNF177
Other names/aliases -
Species Homo sapiens
 Database cross references - ZNF559-ZNF177
ExoCarta ExoCarta_100529215
Vesiclepedia VP_100529215
Entrez Gene 100529215
HGNC 42964
UniProt Q13360  
 ZNF559-ZNF177 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ZNF559-ZNF177
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified ZNF559-ZNF177 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ZNF559-ZNF177
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CIB3  
Two-hybrid Homo sapiens
2 BOLA2B 654483
Two-hybrid Homo sapiens
3 ZGPAT  
Two-hybrid Homo sapiens
4 LMO1  
Two-hybrid Homo sapiens
5 PRKAB2 5565
Two-hybrid Homo sapiens
6 PRKAR1B  
Two-hybrid Homo sapiens
7 SNAPC5  
Two-hybrid Homo sapiens
8 CSNK2A1 1457
Two-hybrid Homo sapiens
9 SNAP25 6616
Two-hybrid Homo sapiens
10 PMVK 10654
Two-hybrid Homo sapiens
11 BOLA2 552900
Two-hybrid Homo sapiens
12 EXOC8 149371
Two-hybrid Homo sapiens
13 CT55  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF559-ZNF177 is involved
No pathways found





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