Gene description for SLC37A4
Gene name solute carrier family 37 (glucose-6-phosphate transporter), member 4
Gene symbol SLC37A4
Other names/aliases G6PT1
G6PT2
G6PT3
GSD1b
GSD1c
GSD1d
PRO0685
TRG-19
TRG19
Species Homo sapiens
 Database cross references - SLC37A4
ExoCarta ExoCarta_2542
Vesiclepedia VP_2542
Entrez Gene 2542
HGNC 4061
MIM 602671
UniProt O43826  
 SLC37A4 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC37A4
Molecular Function
    protein binding GO:0005515 IPI
    glucose-6-phosphate transmembrane transporter activity GO:0015152 IDA
    glucose-6-phosphate transmembrane transporter activity GO:0015152 IMP
    glucose 6-phosphate:phosphate antiporter activity GO:0061513 EXP
    glucose 6-phosphate:phosphate antiporter activity GO:0061513 IBA
    glucose 6-phosphate:phosphate antiporter activity GO:0061513 IDA
    glucose 6-phosphate:phosphate antiporter activity GO:0061513 TAS
Biological Process
    glucose metabolic process GO:0006006 NAS
    gluconeogenesis GO:0006094 TAS
    glucose-6-phosphate transport GO:0015760 IBA
    glucose-6-phosphate transport GO:0015760 IDA
    glucose-6-phosphate transport GO:0015760 IMP
    glucose-6-phosphate transport GO:0015760 NAS
    phosphate ion transmembrane transport GO:0035435 IBA
    phosphate ion transmembrane transport GO:0035435 IDA
    glucose homeostasis GO:0042593 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 NAS
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 HDA
    membrane GO:0016020 NAS
 Experiment description of studies that identified SLC37A4 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC37A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 CALML3 810
Affinity Capture-MS Homo sapiens
3 CLPP 8192
Proximity Label-MS Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 SERPINB4 6318
Affinity Capture-MS Homo sapiens
6 TIMP1 7076
Affinity Capture-MS Homo sapiens
7 SHBG 6462
Two-hybrid Homo sapiens
8 SERPINB7 8710
Affinity Capture-MS Homo sapiens
9 TYMP 1890
Affinity Capture-MS Homo sapiens
10 HMOX1 3162
Affinity Capture-MS Homo sapiens
11 CTSV 1515
Affinity Capture-MS Homo sapiens
12 CBR1 873
Affinity Capture-MS Homo sapiens
13 VTN 7448
Affinity Capture-MS Homo sapiens
14 IL36G 56300
Affinity Capture-MS Homo sapiens
15 POF1B 79983
Affinity Capture-MS Homo sapiens
16 ATP12A 479
Affinity Capture-MS Homo sapiens
17 TSPAN15 23555
Affinity Capture-MS Homo sapiens
18 S100A7A 338324
Affinity Capture-MS Homo sapiens
19 PKP1 5317
Affinity Capture-MS Homo sapiens
20 EVPL 2125
Affinity Capture-MS Homo sapiens
21 GPR35  
Two-hybrid Homo sapiens
22 ZNRF2 223082
Affinity Capture-MS Homo sapiens
23 ARL3 403
Affinity Capture-MS Homo sapiens
24 CALML5 51806
Affinity Capture-MS Homo sapiens
25 PMVK 10654
Affinity Capture-MS Homo sapiens
26 SERPINB3 6317
Affinity Capture-MS Homo sapiens
27 PLA2G4D  
Affinity Capture-MS Homo sapiens
28 LGALS7B 653499
Affinity Capture-MS Homo sapiens
29 SERPINB2 5055
Affinity Capture-MS Homo sapiens
30 ASPH 444
Affinity Capture-MS Homo sapiens
31 ACPP 55
Affinity Capture-MS Homo sapiens
32 EVA1B 55194
Affinity Capture-MS Homo sapiens
33 TGM1 7051
Affinity Capture-MS Homo sapiens
34 IVL 3713
Affinity Capture-MS Homo sapiens
35 TRIM29 23650
Affinity Capture-MS Homo sapiens
36 SDR9C7  
Affinity Capture-MS Homo sapiens
37 KLK10 5655
Affinity Capture-MS Homo sapiens
38 SERPINA3 12
Affinity Capture-MS Homo sapiens
39 ALOX12B  
Affinity Capture-MS Homo sapiens
40 LCN2 3934
Affinity Capture-MS Homo sapiens
41 ENDOU  
Affinity Capture-MS Homo sapiens
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