Gene description for CTSV
Gene name cathepsin V
Gene symbol CTSV
Other names/aliases CATL2
CTSL2
CTSU
Species Homo sapiens
 Database cross references - CTSV
ExoCarta ExoCarta_1515
Entrez Gene 1515
HGNC 2538
MIM 603308
UniProt O60911  
 CTSV identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Thymus 23844026    
 Gene ontology annotations for CTSV
Molecular Function
    aminopeptidase activity GO:0004177 IEA
    kininogen binding GO:0030984 IEA
    protein complex binding GO:0032403 IEA
    cysteine-type peptidase activity GO:0008234 TAS
    protein binding GO:0005515 IPI
    cysteine-type carboxypeptidase activity GO:0016807 IEA
    peptide binding GO:0042277 IEA
    histone binding GO:0042393 IEA
    cysteine-type endopeptidase activity GO:0004197 IEA
Biological Process
    autophagic cell death GO:0048102 IEA
    spermatogenesis GO:0007283 IEA
    response to gonadotropin GO:0034698 IEA
    extracellular matrix organization GO:0030198 TAS
    response to glucose GO:0009749 IEA
    decidualization GO:0046697 IEA
    extracellular matrix disassembly GO:0022617 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
    hair follicle morphogenesis GO:0031069 IEA
    nerve development GO:0021675 IEA
    Sertoli cell differentiation GO:0060008 IEA
    negative regulation of keratinocyte proliferation GO:0010839 IEA
    proteolysis involved in cellular protein catabolic process GO:0051603 IBA
    protein autoprocessing GO:0016540 IEA
    regulation of actin cytoskeleton reorganization GO:2000249 IEA
    response to glucocorticoid GO:0051384 IEA
    multicellular organismal aging GO:0010259 IEA
    cellular response to starvation GO:0009267 IEA
Subcellular Localization
    neuron projection GO:0043005 IEA
    microvillus GO:0005902 IEA
    apical part of cell GO:0045177 IEA
    secretory granule GO:0030141 IEA
    lysosomal lumen GO:0043202 TAS
    nucleolus GO:0005730 IEA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    external side of plasma membrane GO:0009897 IEA
    lysosome GO:0005764 IBA
    extracellular exosome GO:0070062 IDA
    perikaryon GO:0043204 IEA
 Experiment description of studies that identified CTSV in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CTSV
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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