Gene description for CTSV
Gene name cathepsin V
Gene symbol CTSV
Other names/aliases CATL2
CTSL2
CTSU
Species Homo sapiens
 Database cross references - CTSV
ExoCarta ExoCarta_1515
Vesiclepedia VP_1515
Entrez Gene 1515
HGNC 2538
MIM 603308
UniProt O60911  
 CTSV identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Keratinocytes 19530224    
Keratinocytes 19530224    
Thymus 23844026    
 Gene ontology annotations for CTSV
Molecular Function
    cysteine-type endopeptidase activity GO:0004197 IBA
    cysteine-type endopeptidase activity GO:0004197 TAS
    serine-type endopeptidase activity GO:0004252 TAS
    protein binding GO:0005515 IPI
    cysteine-type peptidase activity GO:0008234 TAS
Biological Process
    apoptotic process GO:0006915 IEA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
    extracellular matrix disassembly GO:0022617 TAS
    proteolysis involved in protein catabolic process GO:0051603 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    lysosome GO:0005764 IBA
    lysosomal lumen GO:0043202 TAS
 Experiment description of studies that identified CTSV in sEVs
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 189
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 190
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CTSV
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APTX  
Affinity Capture-MS Homo sapiens
2 SSR4 6748
Co-fractionation Homo sapiens
3 LRRC10  
Affinity Capture-MS Homo sapiens
4 C7orf34  
Affinity Capture-MS Homo sapiens
5 WIF1 11197
Affinity Capture-MS Homo sapiens
6 CST1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 IFNA4  
Affinity Capture-MS Homo sapiens
8 DTL  
Affinity Capture-MS Homo sapiens
9 CCL3L1  
Affinity Capture-MS Homo sapiens
10 COPZ1 22818
Affinity Capture-MS Homo sapiens
11 VNN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CTSL 1514
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SLC25A6 293
Affinity Capture-MS Homo sapiens
14 CCL3  
Affinity Capture-MS Homo sapiens
15 CCDC103  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CTSK 1513
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DEFA1 1667
Affinity Capture-MS Homo sapiens
18 CCNC  
Affinity Capture-MS Homo sapiens
19 MBNL1 4154
Affinity Capture-MS Homo sapiens
20 NRSN1  
Affinity Capture-MS Homo sapiens
21 COPG2 26958
Affinity Capture-MS Homo sapiens
22 DDX19B 11269
Affinity Capture-MS Homo sapiens
23 SH2D3A  
Affinity Capture-MS Homo sapiens
24 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TRIM41 90933
Affinity Capture-MS Homo sapiens
26 MBD4  
Affinity Capture-MS Homo sapiens
27 LIAS  
Affinity Capture-MS Homo sapiens
28 IGF2R 3482
Affinity Capture-MS Homo sapiens
29 PDGFRA 5156
Affinity Capture-MS Homo sapiens
30 CST3 1471
Affinity Capture-MS Homo sapiens
31 ZNF154  
Affinity Capture-MS Homo sapiens
32 PCP4  
Affinity Capture-MS Homo sapiens
33 ZSCAN12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 NPPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 C1orf35  
Affinity Capture-MS Homo sapiens
36 CSTA 1475
Affinity Capture-MS Homo sapiens
37 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 RBFOX1 54715
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 SFR1 119392
Affinity Capture-MS Homo sapiens
40 PLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ST7  
Affinity Capture-MS Homo sapiens
43 RNF10  
Affinity Capture-MS Homo sapiens
44 MYCBPAP 84073
Affinity Capture-MS Homo sapiens
45 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
46 DEFB106A  
Affinity Capture-MS Homo sapiens
47 KLHL11  
Affinity Capture-MS Homo sapiens
48 GALNT9  
Affinity Capture-MS Homo sapiens
49 RNF115  
Affinity Capture-MS Homo sapiens
50 ERCC3  
Affinity Capture-MS Homo sapiens
51 HES4  
Affinity Capture-MS Homo sapiens
52 PTDSS1 9791
Affinity Capture-MS Homo sapiens
53 L2HGDH  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SLC37A4 2542
Affinity Capture-MS Homo sapiens
55 TMCO3 55002
Affinity Capture-MS Homo sapiens
56 FANCG 2189
Affinity Capture-MS Homo sapiens
57 KIR3DS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 TEFM  
Affinity Capture-MS Homo sapiens
59 CST6  
Affinity Capture-MS Homo sapiens
60 TSPAN6 7105
Affinity Capture-MS Homo sapiens
61 PINK1  
Affinity Capture-MS Homo sapiens
62 GOT1 2805
Affinity Capture-MS Homo sapiens
63 FBXO2 26232
Affinity Capture-MS Homo sapiens
64 SARAF  
Affinity Capture-MS Homo sapiens
65 KNG1 3827
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 GINM1 116254
Affinity Capture-MS Homo sapiens
67 E2F6 1876
Affinity Capture-MS Homo sapiens
68 SSUH2  
Affinity Capture-MS Homo sapiens
69 NUDT3 11165
Affinity Capture-MS Homo sapiens
70 ZDHHC6  
Affinity Capture-MS Homo sapiens
71 PMVK 10654
Affinity Capture-MS Homo sapiens
72 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
73 MRM1  
Affinity Capture-MS Homo sapiens
74 ST14 6768
Affinity Capture-MS Homo sapiens
75 RAB28 9364
Affinity Capture-MS Homo sapiens
76 GABPA 2551
Affinity Capture-MS Homo sapiens
77 CCR1  
Affinity Capture-MS Homo sapiens
78 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
79 MMRN1 22915
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 STX17 55014
Affinity Capture-MS Homo sapiens
81 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
82 RIPPLY3  
Affinity Capture-MS Homo sapiens
83 TMPRSS13  
Affinity Capture-MS Homo sapiens
84 TBC1D22A  
Affinity Capture-MS Homo sapiens
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