Gene description for EVPL
Gene name envoplakin
Gene symbol EVPL
Other names/aliases EVPK
Species Homo sapiens
 Database cross references - EVPL
ExoCarta ExoCarta_2125
Vesiclepedia VP_2125
Entrez Gene 2125
HGNC 3503
MIM 601590
UniProt Q92817  
 EVPL identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for EVPL
Molecular Function
    structural molecule activity GO:0005198 IBA
    cadherin binding GO:0045296 HDA
Biological Process
    regulation of antibacterial peptide production GO:0002786 IEA
    epidermis development GO:0008544 TAS
    peptide cross-linking GO:0018149 IDA
    keratinocyte differentiation GO:0030216 IDA
    keratinization GO:0031424 IEA
    wound healing GO:0042060 IBA
    intermediate filament cytoskeleton organization GO:0045104 IBA
Subcellular Localization
    cornified envelope GO:0001533 IDA
    cornified envelope GO:0001533 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    intermediate filament GO:0005882 IBA
    membrane GO:0016020 IBA
    desmosome GO:0030057 IEA
    intermediate filament cytoskeleton GO:0045111 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified EVPL in sEVs
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for EVPL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FNDC5  
Affinity Capture-MS Homo sapiens
2 FNDC1 84624
Affinity Capture-MS Homo sapiens
3 ZSCAN20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PI4KA 5297
Affinity Capture-MS Homo sapiens
5 SLC37A4 2542
Affinity Capture-MS Homo sapiens
6 MRM1  
Affinity Capture-MS Homo sapiens
7 SARAF  
Affinity Capture-MS Homo sapiens
8 KLHL11  
Affinity Capture-MS Homo sapiens
9 HNRNPD 3184
Cross-Linking-MS (XL-MS) Homo sapiens
10 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
11 SLC25A6 293
Affinity Capture-MS Homo sapiens
12 C18orf21  
Affinity Capture-MS Homo sapiens
13 FANCD2  
Affinity Capture-MS Homo sapiens
14 CUL3 8452
Affinity Capture-MS Homo sapiens
15 FRMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PIGT 51604
Affinity Capture-MS Homo sapiens
17 AGPAT1 10554
Affinity Capture-MS Homo sapiens
18 HSF2  
Affinity Capture-MS Homo sapiens
19 FCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 RBM24 221662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CDA 978
Co-fractionation Homo sapiens
22 CCNYL1 151195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 NKAIN3  
Affinity Capture-MS Homo sapiens
26 PC 5091
Co-fractionation Homo sapiens
27 FAM213A 84293
Affinity Capture-MS Homo sapiens
28 GOT1 2805
Affinity Capture-MS Homo sapiens
29 Bcas2  
Affinity Capture-MS Mus musculus
30 P4HA1 5033
Co-fractionation Homo sapiens
31 CCR1  
Affinity Capture-MS Homo sapiens
32 ZSCAN12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 C1orf35  
Affinity Capture-MS Homo sapiens
35 EBF2  
Affinity Capture-MS Homo sapiens
36 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
37 PTDSS1 9791
Affinity Capture-MS Homo sapiens
38 LRRC10  
Affinity Capture-MS Homo sapiens
39 MS4A6E  
Affinity Capture-MS Homo sapiens
40 SSBP2  
Affinity Capture-MS Homo sapiens
41 ST7  
Affinity Capture-MS Homo sapiens
42 BPHL 670
Affinity Capture-MS Homo sapiens
43 SOX2  
Affinity Capture-MS Homo sapiens
44 CERS3  
Affinity Capture-MS Homo sapiens
45 SUSD3 203328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 FAM227B  
Affinity Capture-MS Homo sapiens
47 PLEKHA5 54477
Two-hybrid Homo sapiens
48 ACIN1 22985
Co-fractionation Homo sapiens
49 SRRT 51593
Affinity Capture-MS Homo sapiens
50 ERCC3  
Affinity Capture-MS Homo sapiens
51 PPL 5493
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 MBNL1 4154
Affinity Capture-MS Homo sapiens
53 DROSHA  
Co-fractionation Homo sapiens
54 Ctnnbl1  
Affinity Capture-MS Mus musculus
55 CDH1 999
Proximity Label-MS Homo sapiens
56 RNF115  
Affinity Capture-MS Homo sapiens
57 DYRK1A 1859
Affinity Capture-MS Homo sapiens
58 TEFM  
Affinity Capture-MS Homo sapiens
59 ZC3HC1  
Affinity Capture-MS Homo sapiens
60 ITGA9 3680
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 PINK1  
Affinity Capture-MS Homo sapiens
62 SSUH2  
Affinity Capture-MS Homo sapiens
63 TSNAX 7257
Affinity Capture-MS Homo sapiens
64 RPL27 6155
Co-fractionation Homo sapiens
65 STK11 6794
Affinity Capture-MS Homo sapiens
66 ACAD9 28976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 BBOX1 8424
Affinity Capture-MS Homo sapiens
69 CCDC101  
Affinity Capture-MS Homo sapiens
70 Jup 16480
Affinity Capture-MS Mus musculus
71 OR2A4 79541
Affinity Capture-MS Homo sapiens
72 HCN1  
Affinity Capture-MS Homo sapiens
73 UGT1A10  
Affinity Capture-MS Homo sapiens
74 UPK1A 11045
Affinity Capture-MS Homo sapiens
75 GABPA 2551
Affinity Capture-MS Homo sapiens
76 PHF8  
Affinity Capture-MS Homo sapiens
77 SLC25A17 10478
Co-fractionation Homo sapiens
78 STX17 55014
Affinity Capture-MS Homo sapiens
79 P2RX6  
Affinity Capture-MS Homo sapiens
80 RIPPLY3  
Affinity Capture-MS Homo sapiens
81 AATF  
Affinity Capture-MS Homo sapiens
82 KRT14 3861
Co-fractionation Homo sapiens
83 DSP 1832
Co-fractionation Homo sapiens
84 PHF11 51131
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which EVPL is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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