Gene description for EVPL
Gene name envoplakin
Gene symbol EVPL
Other names/aliases EVPK
Species Homo sapiens
 Database cross references - EVPL
ExoCarta ExoCarta_2125
Entrez Gene 2125
HGNC 3503
MIM 601590
UniProt Q92817  
 EVPL identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for EVPL
Molecular Function
    protein binding, bridging GO:0030674 IDA
    intermediate filament binding GO:0019215 IEA
    structural molecule activity GO:0005198 IDA
Biological Process
    epidermis development GO:0008544 TAS
    peptide cross-linking GO:0018149 IDA
    keratinocyte differentiation GO:0030216 IDA
    keratinization GO:0031424 IEA
Subcellular Localization
    desmosome GO:0030057 IEA
    cytoskeleton GO:0005856 IEA
    cornified envelope GO:0001533 IDA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified EVPL in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for EVPL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPL 5493
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Co-localization Homo sapiens
View the network image/svg+xml
 Pathways in which EVPL is involved
No pathways found





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