Gene description for Jup
Gene name junction plakoglobin
Gene symbol Jup
Other names/aliases Ctnng
Species Mus musculus
 Database cross references - Jup
ExoCarta ExoCarta_16480
Entrez Gene 16480
UniProt Q02257  
 Jup identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Jup
Molecular Function
    alpha-catenin binding GO:0045294 ISO
    transcription coactivator activity GO:0003713 ISO
    protein phosphatase binding GO:0019903 ISO
    protein binding GO:0005515 IPI
    structural molecule activity GO:0005198 ISO
    cadherin binding GO:0045296 ISO
    cell adhesion molecule binding GO:0050839 ISO
    signal transducer activity GO:0004871 IEA
    protein kinase binding GO:0019901 ISO
Biological Process
    establishment of protein localization to plasma membrane GO:0090002 ISO
    regulation of cell proliferation GO:0042127 ISO
    cell migration GO:0016477 ISO
    regulation of nucleic acid-templated transcription GO:1903506 IBA
    cell adhesion GO:0007155 IDA
    desmosome assembly GO:0002159 ISO
    regulation of ventricular cardiac muscle cell action potential GO:0098911 ISO
    adherens junction assembly GO:0034333 IEA
    skin development GO:0043588 IMP
    regulation of cell fate specification GO:0042659 IBA
    positive regulation of protein import into nucleus GO:0042307 ISO
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 ISO
    detection of mechanical stimulus GO:0050982 ISO
    cellular response to indole-3-methanol GO:0071681 ISO
    bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 ISO
    protein heterooligomerization GO:0051291 ISO
    regulation of heart rate by cardiac conduction GO:0086091 ISO
    single organismal cell-cell adhesion GO:0016337 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
    plasma membrane GO:0005886 ISO
    intermediate filament GO:0005882 IDA
    cell-cell adherens junction GO:0005913 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISO
    focal adhesion GO:0005925 ISO
    cytosol GO:0005829 IDA
    catenin complex GO:0016342 ISO
    protein-DNA complex GO:0032993 ISO
    intercalated disc GO:0014704 ISO
    apicolateral plasma membrane GO:0016327 ISO
    cytoskeleton GO:0005856 IEA
    gamma-catenin-TCF7L2 complex GO:0071665 ISO
    desmosome GO:0030057 ISO
    cytoplasm GO:0005737 ISO
    fascia adherens GO:0005916 ISO
    lateral plasma membrane GO:0016328 ISO
    Z disc GO:0030018 IDA
    cell-cell junction GO:0005911 ISO
    membrane GO:0016020 IDA
    cell junction GO:0030054 IEA
    actin cytoskeleton GO:0015629 ISO
 Experiment description of studies that identified Jup in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Jup
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Jup is involved
Adherens junctions interactions IEA Reactome
VEGFR2 mediated vascular permeability IEA Reactome

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