Gene description for ARID5B
Gene name AT rich interactive domain 5B (MRF1-like)
Gene symbol ARID5B
Other names/aliases DESRT
MRF-2
MRF2
Species Homo sapiens
 Database cross references - ARID5B
ExoCarta ExoCarta_84159
Entrez Gene 84159
HGNC 17362
MIM 608538
UniProt Q14865  
 ARID5B identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ARID5B
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IDA
    DNA binding GO:0003677 IDA
    transcription coactivator activity GO:0003713 IDA
    transcription regulatory region DNA binding GO:0044212 IDA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001227 IDA
Biological Process
    palate development GO:0060021 IEA
    muscle organ morphogenesis GO:0048644 IEA
    female gonad development GO:0008585 IEA
    fibroblast migration GO:0010761 IEA
    fat cell differentiation GO:0045444 IEA
    liver development GO:0001889 TAS
    kidney development GO:0001822 IEA
    platelet-derived growth factor receptor signaling pathway GO:0048008 IEA
    fat pad development GO:0060613 IEA
    post-embryonic development GO:0009791 IEA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    skeletal system morphogenesis GO:0048705 IEA
    adrenal gland development GO:0030325 IEA
    chromatin organization GO:0006325 TAS
    adipose tissue development GO:0060612 ISS
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IDA
    cell development GO:0048468 IEA
    negative regulation of transcription, DNA-templated GO:0045892 TAS
    face morphogenesis GO:0060325 IEA
    male gonad development GO:0008584 IEA
    multicellular organism growth GO:0035264 IEA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 IBA
 Experiment description of studies that identified ARID5B in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARID5B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ARID5B is involved
PathwayEvidenceSource
HDMs demethylate histones TAS Reactome





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