Gene description for ARID5B
Gene name AT rich interactive domain 5B (MRF1-like)
Gene symbol ARID5B
Other names/aliases DESRT
MRF-2
MRF2
Species Homo sapiens
 Database cross references - ARID5B
ExoCarta ExoCarta_84159
Vesiclepedia VP_84159
Entrez Gene 84159
HGNC 17362
MIM 608538
UniProt Q14865  
 ARID5B identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ARID5B
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IBA
    transcription cis-regulatory region binding GO:0000976 IDA
    DNA binding GO:0003677 IDA
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    kidney development GO:0001822 IEA
    liver development GO:0001889 TAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    male gonad development GO:0008584 IEA
    female gonad development GO:0008585 IEA
    post-embryonic development GO:0009791 IEA
    fibroblast migration GO:0010761 IEA
    adrenal gland development GO:0030325 IEA
    multicellular organism growth GO:0035264 IEA
    fat cell differentiation GO:0045444 IEA
    negative regulation of DNA-templated transcription GO:0045892 TAS
    positive regulation of DNA-templated transcription GO:0045893 IEA
    platelet-derived growth factor receptor signaling pathway GO:0048008 IEA
    cell development GO:0048468 IEA
    muscle organ morphogenesis GO:0048644 IEA
    skeletal system morphogenesis GO:0048705 IEA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IDA
    roof of mouth development GO:0060021 IEA
    face morphogenesis GO:0060325 IEA
    adipose tissue development GO:0060612 ISS
    fat pad development GO:0060613 IEA
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified ARID5B in exosomes
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARID5B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SOX7  
Proximity Label-MS Homo sapiens
2 BCL11B  
Affinity Capture-MS Homo sapiens
3 ISG15 9636
Affinity Capture-MS Homo sapiens
4 FASN 2194
Negative Genetic Homo sapiens
5 DVL2 1856
Affinity Capture-MS Homo sapiens
6 ASF1A 25842
Proximity Label-MS Homo sapiens
7 HDAC2 3066
Affinity Capture-MS Homo sapiens
8 Psmb5 19173
Affinity Capture-MS Mus musculus
9 KIF14 9928
Affinity Capture-MS Homo sapiens
10 NR3C1 2908
Proximity Label-MS Homo sapiens
11 EGLN3  
Affinity Capture-MS Homo sapiens
12 Smc3 13006
Affinity Capture-MS Mus musculus
13 RACGAP1 29127
Affinity Capture-MS Homo sapiens
14 LRRC25  
Affinity Capture-MS Homo sapiens
15 H2AFZ 3015
Affinity Capture-MS Homo sapiens
16 HIST1H2BG 8339
Affinity Capture-MS Homo sapiens
17 GATA2  
Proximity Label-MS Homo sapiens
18 KLF3  
Proximity Label-MS Homo sapiens
19 SNX27 81609
Affinity Capture-MS Homo sapiens
20 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
21 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
22 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
23 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 FOXL1  
Proximity Label-MS Homo sapiens
25 YIPF5 81555
Affinity Capture-MS Homo sapiens
26 THSD4 79875
Affinity Capture-MS Homo sapiens
27 CLTCL1 8218
Affinity Capture-MS Homo sapiens
28 CAND1 55832
Affinity Capture-MS Homo sapiens
29 Kat8  
Affinity Capture-MS Mus musculus
30 HIST1H2BE 8344
Affinity Capture-MS Homo sapiens
31 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
32 HIST1H2BA 255626
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 MIER1  
Affinity Capture-MS Homo sapiens
34 METTL3  
Affinity Capture-MS Homo sapiens
35 CCDC8  
Affinity Capture-MS Homo sapiens
36 RPN1 6184
Cross-Linking-MS (XL-MS) Homo sapiens
37 HNF1B  
Proximity Label-MS Homo sapiens
38 Jup 16480
Affinity Capture-MS Mus musculus
39 Kctd5  
Affinity Capture-MS Mus musculus
40 AR 367
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
41 FBXW8 26259
Affinity Capture-MS Homo sapiens
42 PARD6A  
Affinity Capture-MS Homo sapiens
43 FBXO38 81545
Proximity Label-MS Homo sapiens
44 SP7  
Proximity Label-MS Homo sapiens
45 C16orf87 388272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 TEAD1  
Proximity Label-MS Homo sapiens
47 HIST1H2BI 8346
Affinity Capture-MS Homo sapiens
48 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
49 CHORDC1 26973
Affinity Capture-MS Homo sapiens
50 BCOR  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ARID5B is involved
PathwayEvidenceSource
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
HDMs demethylate histones TAS Reactome





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