Gene description for Smc3
Gene name structural maintenance of chromosomes 3
Gene symbol Smc3
Other names/aliases Bamacan
Cspg6
HCAP
Mmip1
SMC-3
SmcD
Species Mus musculus
 Database cross references - Smc3
ExoCarta ExoCarta_13006
Entrez Gene 13006
UniProt Q9CW03  
 Smc3 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Smc3
Molecular Function
    ATP binding GO:0005524 IEA
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
    dynein binding GO:0045502 ISO
    nucleotide binding GO:0000166 IEA
    protein heterodimerization activity GO:0046982 ISO
    mediator complex binding GO:0036033 IDA
Biological Process
    DNA repair GO:0006281 IEA
    mitotic nuclear division GO:0007067 IEA
    cellular response to DNA damage stimulus GO:0006974 IEA
    meiotic nuclear division GO:0007126 ISO
    chromosome organization GO:0051276 IEA
    stem cell maintenance GO:0019827 IMP
    sister chromatid cohesion GO:0007062 ISO
    signal transduction GO:0007165 ISO
    meiotic cell cycle GO:0051321 IEA
    cell division GO:0051301 IEA
    regulation of DNA replication GO:0006275 ISO
    cell cycle GO:0007049 IEA
    negative regulation of DNA endoreduplication GO:0032876 ISO
    mitotic sister chromatid cohesion GO:0007064 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    meiotic cohesin complex GO:0030893 ISO
    cohesin core heterodimer GO:0008280 IEA
    chromosome GO:0005694 IEA
    nucleoplasm GO:0005654 ISO
    chromosome, centromeric region GO:0000775 IEA
    spindle pole GO:0000922 ISO
    cytoplasm GO:0005737 ISO
    nuclear meiotic cohesin complex GO:0034991 IDA
    lateral element GO:0000800 IDA
    nuclear matrix GO:0016363 ISO
    basement membrane GO:0005604 ISO
    chromatin GO:0000785 ISO
 Experiment description of studies that identified Smc3 in exosomes
1
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Smc3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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