Gene description for ZFYVE26
Gene name zinc finger, FYVE domain containing 26
Gene symbol ZFYVE26
Other names/aliases FYVE-CENT
SPG15
Species Homo sapiens
 Database cross references - ZFYVE26
ExoCarta ExoCarta_23503
Entrez Gene 23503
HGNC 20761
MIM 612012
UniProt Q68DK2  
 ZFYVE26 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for ZFYVE26
Molecular Function
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    phosphatidylinositol-3-phosphate binding GO:0032266 IDA
Biological Process
    cytokinesis GO:0000910 IMP
    double-strand break repair via homologous recombination GO:0000724 IMP
Subcellular Localization
    lysosomal membrane GO:0005765 IDA
    midbody GO:0030496 IDA
    centrosome GO:0005813 IDA
 Experiment description of studies that identified ZFYVE26 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for ZFYVE26
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ZFYVE26 is involved
No pathways found





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