Gene description for RUSC2
Gene name RUN and SH3 domain containing 2
Gene symbol RUSC2
Other names/aliases Iporin
Species Homo sapiens
 Database cross references - RUSC2
ExoCarta ExoCarta_9853
Vesiclepedia VP_9853
Entrez Gene 9853
HGNC 23625
MIM 611053
UniProt Q8N2Y8  
 RUSC2 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for RUSC2
Molecular Function
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IPI
Subcellular Localization
    cytosol GO:0005829 IEA
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified RUSC2 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for RUSC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 KLC2 64837
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 RAB1A 5861
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 MSH6 2956
Affinity Capture-MS Homo sapiens
5 NFE2L1  
Affinity Capture-MS Homo sapiens
6 ATG9A 79065
Affinity Capture-Western Homo sapiens
7 Smc3 13006
Affinity Capture-MS Mus musculus
8 GIT2 9815
Two-hybrid Homo sapiens
9 KPNB1 3837
Affinity Capture-MS Homo sapiens
10 EGFR 1956
PCA Homo sapiens
11 CDKN1A  
Affinity Capture-MS Homo sapiens
12 KLC1 3831
Affinity Capture-MS Homo sapiens
13 KIFAP3 22920
Affinity Capture-MS Homo sapiens
14 WEE1 7465
Affinity Capture-MS Homo sapiens
15 GOLGA2 2801
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
16 MAGEC1  
Two-hybrid Homo sapiens
17 XPO1 7514
Affinity Capture-MS Homo sapiens
18 Sept6  
Affinity Capture-MS Mus musculus
19 CEP135  
Proximity Label-MS Homo sapiens
20 DLST 1743
Two-hybrid Homo sapiens
21 KIF5B 3799
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
22 Chmp6  
Affinity Capture-MS Mus musculus
23 KHDRBS1 10657
Protein-peptide Homo sapiens
24 WDR47  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RUSC2 is involved
No pathways found





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