Gene description for MSH6
Gene name	mutS homolog 6
Gene symbol	MSH6
Other names/aliases	GTBP GTMBP HNPCC5 HSAP p160
Species	Homo sapiens
Database cross references - MSH6
ExoCarta	ExoCarta_2956
Entrez Gene	2956
HGNC	7329
MIM	600678
UniProt	P52701
MSH6 identified in exosomes derived from the following tissue/cell type
Plasma	19028452
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for MSH6

Molecular Function     ATP binding GO:0005524 IDA     methylated histone binding GO:0035064 IDA     DNA-dependent ATPase activity GO:0008094 IBA     single guanine insertion binding GO:0032142 IDA     ADP binding GO:0043531 IDA     chromatin binding GO:0003682 IEA     guanine/thymine mispair binding GO:0032137 IDA     ATPase activity GO:0016887 IDA     protein binding GO:0005515 IPI     MutLalpha complex binding GO:0032405 IDA     protein homodimerization activity GO:0042803 IPI     oxidized purine DNA binding GO:0032357 IDA     single thymine insertion binding GO:0032143 IDA     four-way junction DNA binding GO:0000400 IDA     double-stranded DNA binding GO:0003690 IDA     mismatched DNA binding GO:0030983 IDA     magnesium ion binding GO:0000287 IDA Biological Process     somatic recombination of immunoglobulin gene segments GO:0016447 ISS     reciprocal meiotic recombination GO:0007131 IBA     response to UV GO:0009411 ISS     DNA repair GO:0006281 TAS     determination of adult lifespan GO:0008340 ISS     mismatch repair GO:0006298 TAS     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 ISS     isotype switching GO:0045190 ISS     negative regulation of DNA recombination GO:0045910 IDA     intrinsic apoptotic signaling pathway GO:0097193 ISS     positive regulation of helicase activity GO:0051096 IDA     viral process GO:0016032 IEA     maintenance of DNA repeat elements GO:0043570 IMP     somatic hypermutation of immunoglobulin genes GO:0016446 ISS     meiotic mismatch repair GO:0000710 ISS Subcellular Localization     plasma membrane GO:0005886 IDA     nuclear chromatin GO:0000790 IEA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     nuclear chromosome GO:0000228 IBA     MutSalpha complex GO:0032301 IDA     Golgi apparatus GO:0005794 IDA     intracellular membrane-bounded organelle GO:0043231 IDA